Centrocestus formosanus (Heterophyidae)

Human infections and the infection source in Lao PDR

Jong Yil Chai, Woon Mok Sohn, Tai Soon Yong, Keeseon S. Eom, Duk Young Min, Mi Youn Lee, Hyemi Lim, Bounnaloth Insisiengmay, Bounlay Phommasack, Han Jong Rim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In Lao People's Democratic Republic (PDR), we detected 7 patients infected with Centrocestus formosanus (1-122 adult specimens) after praziquantel treatment and purgation, together with several other trematode species including Opisthorchis viverrini and Haplorchis taichui. The patients were all men, 23-42 yr-of-age. Three subjects were from Vientiane Municipality and 1 each were from Khammouane, Saravane, Champassak, and Xiengkhouang Province. The patients had frequently eaten raw freshwater fish and were experiencing variable degrees of epigastric pain and indigestion accompanied by occasional diarrhea, although the relationship of these symptoms with C. formosanus infection was unclear. Centrocestus formosanus specimens were ovoid, 0.46 mm (0.41-0.52 mm) long, and 0.18 mm (0.16-0.20 mm) wide (n = 10) and were equipped with 32 circumoral spines on the oral sucker. The uterine eggs were 33.2 μm long (31.8-34.9 μm) and 18.5 μm wide (17.4-19.8 μm) (n = 20). Analysis of the nucleotide sequence of the 18S ribosomal RNA gene of our specimens (Laotian isolate) revealed 100% homology with that of an isolate from the United States reported in GenBank. Several species of freshwater fish collected from Xiengkhouang Province revealed a 17.0% prevalence (9 of 53 fish examined) for C. formosanus metacercariae. The results suggest that human C. formosanus infections have been masked by other trematode infections.

Original languageEnglish
Pages (from-to)531-536
Number of pages6
JournalJournal of Parasitology
Volume99
Issue number3
DOIs
Publication statusPublished - 2013 Jun 1

Fingerprint

Heterophyidae
Laos
Fishes
Fresh Water
freshwater fish
Haplorchis
Opisthorchis viverrini
Trematode Infections
fish
Infection
18S Ribosomal RNA
Opisthorchis
infection
fish roe
Metacercariae
indigestion
trematode infections
praziquantel
Praziquantel
metacercariae

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Chai, Jong Yil ; Sohn, Woon Mok ; Yong, Tai Soon ; Eom, Keeseon S. ; Min, Duk Young ; Lee, Mi Youn ; Lim, Hyemi ; Insisiengmay, Bounnaloth ; Phommasack, Bounlay ; Rim, Han Jong. / Centrocestus formosanus (Heterophyidae) : Human infections and the infection source in Lao PDR. In: Journal of Parasitology. 2013 ; Vol. 99, No. 3. pp. 531-536.
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title = "Centrocestus formosanus (Heterophyidae): Human infections and the infection source in Lao PDR",
abstract = "In Lao People's Democratic Republic (PDR), we detected 7 patients infected with Centrocestus formosanus (1-122 adult specimens) after praziquantel treatment and purgation, together with several other trematode species including Opisthorchis viverrini and Haplorchis taichui. The patients were all men, 23-42 yr-of-age. Three subjects were from Vientiane Municipality and 1 each were from Khammouane, Saravane, Champassak, and Xiengkhouang Province. The patients had frequently eaten raw freshwater fish and were experiencing variable degrees of epigastric pain and indigestion accompanied by occasional diarrhea, although the relationship of these symptoms with C. formosanus infection was unclear. Centrocestus formosanus specimens were ovoid, 0.46 mm (0.41-0.52 mm) long, and 0.18 mm (0.16-0.20 mm) wide (n = 10) and were equipped with 32 circumoral spines on the oral sucker. The uterine eggs were 33.2 μm long (31.8-34.9 μm) and 18.5 μm wide (17.4-19.8 μm) (n = 20). Analysis of the nucleotide sequence of the 18S ribosomal RNA gene of our specimens (Laotian isolate) revealed 100{\%} homology with that of an isolate from the United States reported in GenBank. Several species of freshwater fish collected from Xiengkhouang Province revealed a 17.0{\%} prevalence (9 of 53 fish examined) for C. formosanus metacercariae. The results suggest that human C. formosanus infections have been masked by other trematode infections.",
author = "Chai, {Jong Yil} and Sohn, {Woon Mok} and Yong, {Tai Soon} and Eom, {Keeseon S.} and Min, {Duk Young} and Lee, {Mi Youn} and Hyemi Lim and Bounnaloth Insisiengmay and Bounlay Phommasack and Rim, {Han Jong}",
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Chai, JY, Sohn, WM, Yong, TS, Eom, KS, Min, DY, Lee, MY, Lim, H, Insisiengmay, B, Phommasack, B & Rim, HJ 2013, 'Centrocestus formosanus (Heterophyidae): Human infections and the infection source in Lao PDR', Journal of Parasitology, vol. 99, no. 3, pp. 531-536. https://doi.org/10.1645/12-37.1

Centrocestus formosanus (Heterophyidae) : Human infections and the infection source in Lao PDR. / Chai, Jong Yil; Sohn, Woon Mok; Yong, Tai Soon; Eom, Keeseon S.; Min, Duk Young; Lee, Mi Youn; Lim, Hyemi; Insisiengmay, Bounnaloth; Phommasack, Bounlay; Rim, Han Jong.

In: Journal of Parasitology, Vol. 99, No. 3, 01.06.2013, p. 531-536.

Research output: Contribution to journalArticle

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AU - Chai, Jong Yil

AU - Sohn, Woon Mok

AU - Yong, Tai Soon

AU - Eom, Keeseon S.

AU - Min, Duk Young

AU - Lee, Mi Youn

AU - Lim, Hyemi

AU - Insisiengmay, Bounnaloth

AU - Phommasack, Bounlay

AU - Rim, Han Jong

PY - 2013/6/1

Y1 - 2013/6/1

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