Abstract
In Lao People's Democratic Republic (PDR), we detected 7 patients infected with Centrocestus formosanus (1-122 adult specimens) after praziquantel treatment and purgation, together with several other trematode species including Opisthorchis viverrini and Haplorchis taichui. The patients were all men, 23-42 yr-of-age. Three subjects were from Vientiane Municipality and 1 each were from Khammouane, Saravane, Champassak, and Xiengkhouang Province. The patients had frequently eaten raw freshwater fish and were experiencing variable degrees of epigastric pain and indigestion accompanied by occasional diarrhea, although the relationship of these symptoms with C. formosanus infection was unclear. Centrocestus formosanus specimens were ovoid, 0.46 mm (0.41-0.52 mm) long, and 0.18 mm (0.16-0.20 mm) wide (n = 10) and were equipped with 32 circumoral spines on the oral sucker. The uterine eggs were 33.2 μm long (31.8-34.9 μm) and 18.5 μm wide (17.4-19.8 μm) (n = 20). Analysis of the nucleotide sequence of the 18S ribosomal RNA gene of our specimens (Laotian isolate) revealed 100% homology with that of an isolate from the United States reported in GenBank. Several species of freshwater fish collected from Xiengkhouang Province revealed a 17.0% prevalence (9 of 53 fish examined) for C. formosanus metacercariae. The results suggest that human C. formosanus infections have been masked by other trematode infections.
| Original language | English |
|---|---|
| Pages (from-to) | 531-536 |
| Number of pages | 6 |
| Journal | Journal of Parasitology |
| Volume | 99 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 Jun 1 |
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All Science Journal Classification (ASJC) codes
- Parasitology
- Ecology, Evolution, Behavior and Systematics
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Centrocestus formosanus (Heterophyidae) : Human infections and the infection source in Lao PDR. / Chai, Jong Yil; Sohn, Woon Mok; Yong, Tai Soon; Eom, Keeseon S.; Min, Duk Young; Lee, Mi Youn; Lim, Hyemi; Insisiengmay, Bounnaloth; Phommasack, Bounlay; Rim, Han Jong.
In: Journal of Parasitology, Vol. 99, No. 3, 01.06.2013, p. 531-536.Research output: Contribution to journal › Article
TY - JOUR
T1 - Centrocestus formosanus (Heterophyidae)
T2 - Human infections and the infection source in Lao PDR
AU - Chai, Jong Yil
AU - Sohn, Woon Mok
AU - Yong, Tai Soon
AU - Eom, Keeseon S.
AU - Min, Duk Young
AU - Lee, Mi Youn
AU - Lim, Hyemi
AU - Insisiengmay, Bounnaloth
AU - Phommasack, Bounlay
AU - Rim, Han Jong
PY - 2013/6/1
Y1 - 2013/6/1
N2 - In Lao People's Democratic Republic (PDR), we detected 7 patients infected with Centrocestus formosanus (1-122 adult specimens) after praziquantel treatment and purgation, together with several other trematode species including Opisthorchis viverrini and Haplorchis taichui. The patients were all men, 23-42 yr-of-age. Three subjects were from Vientiane Municipality and 1 each were from Khammouane, Saravane, Champassak, and Xiengkhouang Province. The patients had frequently eaten raw freshwater fish and were experiencing variable degrees of epigastric pain and indigestion accompanied by occasional diarrhea, although the relationship of these symptoms with C. formosanus infection was unclear. Centrocestus formosanus specimens were ovoid, 0.46 mm (0.41-0.52 mm) long, and 0.18 mm (0.16-0.20 mm) wide (n = 10) and were equipped with 32 circumoral spines on the oral sucker. The uterine eggs were 33.2 μm long (31.8-34.9 μm) and 18.5 μm wide (17.4-19.8 μm) (n = 20). Analysis of the nucleotide sequence of the 18S ribosomal RNA gene of our specimens (Laotian isolate) revealed 100% homology with that of an isolate from the United States reported in GenBank. Several species of freshwater fish collected from Xiengkhouang Province revealed a 17.0% prevalence (9 of 53 fish examined) for C. formosanus metacercariae. The results suggest that human C. formosanus infections have been masked by other trematode infections.
AB - In Lao People's Democratic Republic (PDR), we detected 7 patients infected with Centrocestus formosanus (1-122 adult specimens) after praziquantel treatment and purgation, together with several other trematode species including Opisthorchis viverrini and Haplorchis taichui. The patients were all men, 23-42 yr-of-age. Three subjects were from Vientiane Municipality and 1 each were from Khammouane, Saravane, Champassak, and Xiengkhouang Province. The patients had frequently eaten raw freshwater fish and were experiencing variable degrees of epigastric pain and indigestion accompanied by occasional diarrhea, although the relationship of these symptoms with C. formosanus infection was unclear. Centrocestus formosanus specimens were ovoid, 0.46 mm (0.41-0.52 mm) long, and 0.18 mm (0.16-0.20 mm) wide (n = 10) and were equipped with 32 circumoral spines on the oral sucker. The uterine eggs were 33.2 μm long (31.8-34.9 μm) and 18.5 μm wide (17.4-19.8 μm) (n = 20). Analysis of the nucleotide sequence of the 18S ribosomal RNA gene of our specimens (Laotian isolate) revealed 100% homology with that of an isolate from the United States reported in GenBank. Several species of freshwater fish collected from Xiengkhouang Province revealed a 17.0% prevalence (9 of 53 fish examined) for C. formosanus metacercariae. The results suggest that human C. formosanus infections have been masked by other trematode infections.
UR - http://www.scopus.com/inward/record.url?scp=84878721554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878721554&partnerID=8YFLogxK
U2 - 10.1645/12-37.1
DO - 10.1645/12-37.1
M3 - Article
C2 - 23116489
AN - SCOPUS:84878721554
VL - 99
SP - 531
EP - 536
JO - Journal of Parasitology
JF - Journal of Parasitology
SN - 0022-3395
IS - 3
ER -