Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients

Jong Suk Park, Min Ho Cho, Kyung Yul Lee, Chul Sik Kim, Hai Jin Kim, Ji Sun Nam, Chul Woo Ahn, Bong Soo Cha, Eun Jig Lee, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Diabetic patients have a threefold risk for cerebrovascular disease compared with nondiabetic controls. The aim of the present study was to investigate the association of insulin resistance with the pulsatility index (PI) of cerebral arteries in type 2 diabetic patients. We compared a group of 90 patients with stroke-free, type 2 diabetes and an age- and sex-matched control group of 45 healthy subjects without diabetes. We then evaluated the PI of the middle cerebral artery (MCA) by transcranial Doppler ultrasonography (TCD), and insulin resistance was determined by a short insulin tolerance test. The PI was significantly higher in diabetic patients than in healthy controls (p < 0.05) and also higher in patients with insulin resistance than that seen in insulin sensitive diabetic patients (p < 0.05). The PI of the MCA was significantly correlated with age (R = 0.465, p < 0.01), duration of diabetes (R = 0.264, p = 0.025) and hypertension (R = 0.285, p = 0.015) and inversely correlated with the insulin resistance index (Kitt: R = -0.359, p = 0.030). A multiple regression analysis was performed with PI as the dependent variable and insulin resistance as an independent variable along with known clinical risk factors. Age (β = 0.393, p < 0.01) and duration of diabetes (β = 0.274, p = 0.043) exhibited a significant independent contribution to PI. PI could be a useful marker in the detection of diabetic cerebrovascular changes, and insulin resistance showed correlations with PI, but age and the duration of diabetes contributed independently to the variability in the PI.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume79
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

Fingerprint

Insulin Resistance
Middle Cerebral Artery
Insulin
Doppler Transcranial Ultrasonography
Cerebrovascular Disorders
Cerebral Arteries
Type 2 Diabetes Mellitus
Healthy Volunteers
Research Design
Stroke
Regression Analysis
Hypertension
Control Groups

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Park, J. S., Cho, M. H., Lee, K. Y., Kim, C. S., Kim, H. J., Nam, J. S., ... Lee, H. C. (2008). Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients. Diabetes Research and Clinical Practice, 79(2), 237-242. https://doi.org/10.1016/j.diabres.2007.08.029
Park, Jong Suk ; Cho, Min Ho ; Lee, Kyung Yul ; Kim, Chul Sik ; Kim, Hai Jin ; Nam, Ji Sun ; Ahn, Chul Woo ; Cha, Bong Soo ; Lee, Eun Jig ; Lim, Sung Kil ; Kim, Kyung Rae ; Lee, Hyun Chul. / Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients. In: Diabetes Research and Clinical Practice. 2008 ; Vol. 79, No. 2. pp. 237-242.
@article{aded68431c7e4b20be0f8e92c00fab9c,
title = "Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients",
abstract = "Diabetic patients have a threefold risk for cerebrovascular disease compared with nondiabetic controls. The aim of the present study was to investigate the association of insulin resistance with the pulsatility index (PI) of cerebral arteries in type 2 diabetic patients. We compared a group of 90 patients with stroke-free, type 2 diabetes and an age- and sex-matched control group of 45 healthy subjects without diabetes. We then evaluated the PI of the middle cerebral artery (MCA) by transcranial Doppler ultrasonography (TCD), and insulin resistance was determined by a short insulin tolerance test. The PI was significantly higher in diabetic patients than in healthy controls (p < 0.05) and also higher in patients with insulin resistance than that seen in insulin sensitive diabetic patients (p < 0.05). The PI of the MCA was significantly correlated with age (R = 0.465, p < 0.01), duration of diabetes (R = 0.264, p = 0.025) and hypertension (R = 0.285, p = 0.015) and inversely correlated with the insulin resistance index (Kitt: R = -0.359, p = 0.030). A multiple regression analysis was performed with PI as the dependent variable and insulin resistance as an independent variable along with known clinical risk factors. Age (β = 0.393, p < 0.01) and duration of diabetes (β = 0.274, p = 0.043) exhibited a significant independent contribution to PI. PI could be a useful marker in the detection of diabetic cerebrovascular changes, and insulin resistance showed correlations with PI, but age and the duration of diabetes contributed independently to the variability in the PI.",
author = "Park, {Jong Suk} and Cho, {Min Ho} and Lee, {Kyung Yul} and Kim, {Chul Sik} and Kim, {Hai Jin} and Nam, {Ji Sun} and Ahn, {Chul Woo} and Cha, {Bong Soo} and Lee, {Eun Jig} and Lim, {Sung Kil} and Kim, {Kyung Rae} and Lee, {Hyun Chul}",
year = "2008",
month = "2",
day = "1",
doi = "10.1016/j.diabres.2007.08.029",
language = "English",
volume = "79",
pages = "237--242",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Park, JS, Cho, MH, Lee, KY, Kim, CS, Kim, HJ, Nam, JS, Ahn, CW, Cha, BS, Lee, EJ, Lim, SK, Kim, KR & Lee, HC 2008, 'Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients', Diabetes Research and Clinical Practice, vol. 79, no. 2, pp. 237-242. https://doi.org/10.1016/j.diabres.2007.08.029

Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients. / Park, Jong Suk; Cho, Min Ho; Lee, Kyung Yul; Kim, Chul Sik; Kim, Hai Jin; Nam, Ji Sun; Ahn, Chul Woo; Cha, Bong Soo; Lee, Eun Jig; Lim, Sung Kil; Kim, Kyung Rae; Lee, Hyun Chul.

In: Diabetes Research and Clinical Practice, Vol. 79, No. 2, 01.02.2008, p. 237-242.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients

AU - Park, Jong Suk

AU - Cho, Min Ho

AU - Lee, Kyung Yul

AU - Kim, Chul Sik

AU - Kim, Hai Jin

AU - Nam, Ji Sun

AU - Ahn, Chul Woo

AU - Cha, Bong Soo

AU - Lee, Eun Jig

AU - Lim, Sung Kil

AU - Kim, Kyung Rae

AU - Lee, Hyun Chul

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Diabetic patients have a threefold risk for cerebrovascular disease compared with nondiabetic controls. The aim of the present study was to investigate the association of insulin resistance with the pulsatility index (PI) of cerebral arteries in type 2 diabetic patients. We compared a group of 90 patients with stroke-free, type 2 diabetes and an age- and sex-matched control group of 45 healthy subjects without diabetes. We then evaluated the PI of the middle cerebral artery (MCA) by transcranial Doppler ultrasonography (TCD), and insulin resistance was determined by a short insulin tolerance test. The PI was significantly higher in diabetic patients than in healthy controls (p < 0.05) and also higher in patients with insulin resistance than that seen in insulin sensitive diabetic patients (p < 0.05). The PI of the MCA was significantly correlated with age (R = 0.465, p < 0.01), duration of diabetes (R = 0.264, p = 0.025) and hypertension (R = 0.285, p = 0.015) and inversely correlated with the insulin resistance index (Kitt: R = -0.359, p = 0.030). A multiple regression analysis was performed with PI as the dependent variable and insulin resistance as an independent variable along with known clinical risk factors. Age (β = 0.393, p < 0.01) and duration of diabetes (β = 0.274, p = 0.043) exhibited a significant independent contribution to PI. PI could be a useful marker in the detection of diabetic cerebrovascular changes, and insulin resistance showed correlations with PI, but age and the duration of diabetes contributed independently to the variability in the PI.

AB - Diabetic patients have a threefold risk for cerebrovascular disease compared with nondiabetic controls. The aim of the present study was to investigate the association of insulin resistance with the pulsatility index (PI) of cerebral arteries in type 2 diabetic patients. We compared a group of 90 patients with stroke-free, type 2 diabetes and an age- and sex-matched control group of 45 healthy subjects without diabetes. We then evaluated the PI of the middle cerebral artery (MCA) by transcranial Doppler ultrasonography (TCD), and insulin resistance was determined by a short insulin tolerance test. The PI was significantly higher in diabetic patients than in healthy controls (p < 0.05) and also higher in patients with insulin resistance than that seen in insulin sensitive diabetic patients (p < 0.05). The PI of the MCA was significantly correlated with age (R = 0.465, p < 0.01), duration of diabetes (R = 0.264, p = 0.025) and hypertension (R = 0.285, p = 0.015) and inversely correlated with the insulin resistance index (Kitt: R = -0.359, p = 0.030). A multiple regression analysis was performed with PI as the dependent variable and insulin resistance as an independent variable along with known clinical risk factors. Age (β = 0.393, p < 0.01) and duration of diabetes (β = 0.274, p = 0.043) exhibited a significant independent contribution to PI. PI could be a useful marker in the detection of diabetic cerebrovascular changes, and insulin resistance showed correlations with PI, but age and the duration of diabetes contributed independently to the variability in the PI.

UR - http://www.scopus.com/inward/record.url?scp=38349101304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349101304&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2007.08.029

DO - 10.1016/j.diabres.2007.08.029

M3 - Article

C2 - 17933415

AN - SCOPUS:38349101304

VL - 79

SP - 237

EP - 242

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 2

ER -