Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment

Chulhyoung Lyoo, Yong Jeong, Young Hoon Ryu, Juha O. Rinne, Myung Sik Lee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. Methods: This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into normal cognition (PD-NC, n = 20), single amnestic (PD-SA, n = 12), single nonamnestic (PD-SN, n = 11), and multidomain MCI (PD-MD, n = 18). Using [18F]-fluorodeoxy-glucose PET, cerebral glucose metabolism of MCI groups was compared with that of controls and the PD-NC group. Results: In comparison with controls, PD-NC and PD-SA groups showed no hypometabolic brain areas. However, the PD-SN group showed hypometabolism in parieto-temporo- occipital cortices. The PD-MD group showed widespread hypometabolism that predominantly involved parieto-occipital cortices. In comparison with the PD-NC group, only the PD-MD group showed hypometabolism in lateral frontal, cingulate, and parieto-temporo-occipital cortices. Conclusions: The distribution of hypometabolic brain areas of the PD-MD group suggests that PD-MD seems to be caused by a common pathology with PD dementia. PD-SA and PD-SN seem to be caused by very mild or topographically heterogeneous cerebral dysfunction. Longitudinal clinical and neuroimaging studies are needed to define whether PD patients with single domain MCI progress to PD-MD and finally to dementia.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalEuropean Neurology
Volume64
Issue number2
DOIs
Publication statusPublished - 2010 Aug 1

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Parkinson Disease
Glucose
Occipital Lobe
Cognitive Dysfunction
Dementia
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Lyoo, Chulhyoung ; Jeong, Yong ; Ryu, Young Hoon ; Rinne, Juha O. ; Lee, Myung Sik. / Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment. In: European Neurology. 2010 ; Vol. 64, No. 2. pp. 65-73.
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Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment. / Lyoo, Chulhyoung; Jeong, Yong; Ryu, Young Hoon; Rinne, Juha O.; Lee, Myung Sik.

In: European Neurology, Vol. 64, No. 2, 01.08.2010, p. 65-73.

Research output: Contribution to journalArticle

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AU - Lyoo, Chulhyoung

AU - Jeong, Yong

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AU - Rinne, Juha O.

AU - Lee, Myung Sik

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N2 - Background: Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. Methods: This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into normal cognition (PD-NC, n = 20), single amnestic (PD-SA, n = 12), single nonamnestic (PD-SN, n = 11), and multidomain MCI (PD-MD, n = 18). Using [18F]-fluorodeoxy-glucose PET, cerebral glucose metabolism of MCI groups was compared with that of controls and the PD-NC group. Results: In comparison with controls, PD-NC and PD-SA groups showed no hypometabolic brain areas. However, the PD-SN group showed hypometabolism in parieto-temporo- occipital cortices. The PD-MD group showed widespread hypometabolism that predominantly involved parieto-occipital cortices. In comparison with the PD-NC group, only the PD-MD group showed hypometabolism in lateral frontal, cingulate, and parieto-temporo-occipital cortices. Conclusions: The distribution of hypometabolic brain areas of the PD-MD group suggests that PD-MD seems to be caused by a common pathology with PD dementia. PD-SA and PD-SN seem to be caused by very mild or topographically heterogeneous cerebral dysfunction. Longitudinal clinical and neuroimaging studies are needed to define whether PD patients with single domain MCI progress to PD-MD and finally to dementia.

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