TY - JOUR
T1 - Cerebral metabolic abnormalities in congestive heart failure detected by proton magnetic resonance spectroscopy
AU - Lee, Cheol Whan
AU - Lee, Jung Hee
AU - Kim, Jae Joong
AU - Park, Seong Wook
AU - Hong, Myeong Ki
AU - Kim, Sang Tae
AU - Lim, Tae Hwan
AU - Park, Seung Jung
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/4
Y1 - 1999/4
N2 - OBJECTIVES: Using proton magnetic resonance spectroscopy, we investigated cerebral metabolism and its determinants in congestive heart failure (CHF), and the effects of cardiac transplantation on these measurements. BACKGROUND: Few data are available about cerebral metabolism in CHF. METHODS: Fifty patients with CHF (ejection fraction ≤35%) and 20 healthy volunteers were included for this study. Of the patients, 10 patients underwent heart transplantation. All subjects performed symptom-limited bicycle exercise test. Proton magnetic resonance spectroscopy (1H MRS) was obtained from localized regions (8 to 10 ml) of occipital gray matter (OGM) and parietal white matter (PWM). Absolute levels of the metabolites (N- acetylaspartate, creatine, choline, myo-inositol) were calculated. RESULTS: In PWM only creatine level was significantly lower in CHF than in control subjects, but in OGM all four metabolite levels were decreased in CHF. The creatine level was independently correlated with half-recovery time and duration of heart failure symptoms in PWM (r = -0.56, p < 0.05), and with peak oxygen consumption and serum sodium concentration in OGM (r = 0.58, p < 0.05). Cerebral metabolic abnormalities were improved after successful cardiac transplantation. CONCLUSIONS: This study shows that cerebral metabolism is abnormally deranged in advanced CHF and it may serve as a potential marker of the disease severity.
AB - OBJECTIVES: Using proton magnetic resonance spectroscopy, we investigated cerebral metabolism and its determinants in congestive heart failure (CHF), and the effects of cardiac transplantation on these measurements. BACKGROUND: Few data are available about cerebral metabolism in CHF. METHODS: Fifty patients with CHF (ejection fraction ≤35%) and 20 healthy volunteers were included for this study. Of the patients, 10 patients underwent heart transplantation. All subjects performed symptom-limited bicycle exercise test. Proton magnetic resonance spectroscopy (1H MRS) was obtained from localized regions (8 to 10 ml) of occipital gray matter (OGM) and parietal white matter (PWM). Absolute levels of the metabolites (N- acetylaspartate, creatine, choline, myo-inositol) were calculated. RESULTS: In PWM only creatine level was significantly lower in CHF than in control subjects, but in OGM all four metabolite levels were decreased in CHF. The creatine level was independently correlated with half-recovery time and duration of heart failure symptoms in PWM (r = -0.56, p < 0.05), and with peak oxygen consumption and serum sodium concentration in OGM (r = 0.58, p < 0.05). Cerebral metabolic abnormalities were improved after successful cardiac transplantation. CONCLUSIONS: This study shows that cerebral metabolism is abnormally deranged in advanced CHF and it may serve as a potential marker of the disease severity.
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U2 - 10.1016/S0735-1097(98)00701-3
DO - 10.1016/S0735-1097(98)00701-3
M3 - Article
C2 - 10193716
AN - SCOPUS:0033117191
VL - 33
SP - 1196
EP - 1202
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 5
ER -