Cervical cancer and microchimerism

Donghyun Cha, Kiarash Khosrotehrani, YoungTae Kim, Helene Stroh, Diana W. Bianchi, Kirby L. Johnson

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

OBJECTIVE: To determine whether microchimerism is involved in the pathogenesis or progression of cervical cancer. METHODS: Cervical tissue was obtained from eight women who had at least one live-born son and who underwent radical hysterectomy after a diagnosis of cervical cancer. Control tissue was obtained from four women without cervical cancer who had at least one live-born son and from three women with cervical cancer and no male births. Tissue sections were analyzed with fluorescence in situ hybridization for the presence of fetal cells, defined by an X and Y chromosome. Immunolabeling was used to determine the phenotype of the presumed fetal cells. RESULTS: Male cells were found in cervical tissue from all four patients for whom large sections (approximately 1.5 × 2 cm) were analyzed. Only one male cell was found in two of the four patients for whom small biopsy specimens (approximately 0.1 × 0.5 cm) were analyzed. No male cells were found in tissue specimens from controls, whether they were small or large sections. In immunolabeling studies, eight of 18 male cells from one patient were CD45-positive and nine of 37 male cells from two patients were cytokeratin-positive. No cells were positive for both markers. CONCLUSION: Cervical cancer might be associated with microchimerism, possibly from fetomaternal cell trafficking. These results further expand the potential relationship between microchimerism and disease in women.

Original languageEnglish
Pages (from-to)774-781
Number of pages8
JournalObstetrics and Gynecology
Volume102
Issue number4
DOIs
Publication statusPublished - 2003 Oct 1

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Chimerism
Uterine Cervical Neoplasms
Nuclear Family
Y Chromosome
X Chromosome
Keratins
Hysterectomy
Fluorescence In Situ Hybridization
Parturition
Phenotype
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cha, D., Khosrotehrani, K., Kim, Y., Stroh, H., Bianchi, D. W., & Johnson, K. L. (2003). Cervical cancer and microchimerism. Obstetrics and Gynecology, 102(4), 774-781. https://doi.org/10.1016/S0029-7844(03)00615-X
Cha, Donghyun ; Khosrotehrani, Kiarash ; Kim, YoungTae ; Stroh, Helene ; Bianchi, Diana W. ; Johnson, Kirby L. / Cervical cancer and microchimerism. In: Obstetrics and Gynecology. 2003 ; Vol. 102, No. 4. pp. 774-781.
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Cha, D, Khosrotehrani, K, Kim, Y, Stroh, H, Bianchi, DW & Johnson, KL 2003, 'Cervical cancer and microchimerism', Obstetrics and Gynecology, vol. 102, no. 4, pp. 774-781. https://doi.org/10.1016/S0029-7844(03)00615-X

Cervical cancer and microchimerism. / Cha, Donghyun; Khosrotehrani, Kiarash; Kim, YoungTae; Stroh, Helene; Bianchi, Diana W.; Johnson, Kirby L.

In: Obstetrics and Gynecology, Vol. 102, No. 4, 01.10.2003, p. 774-781.

Research output: Contribution to journalArticle

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AU - Kim, YoungTae

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AU - Bianchi, Diana W.

AU - Johnson, Kirby L.

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Cha D, Khosrotehrani K, Kim Y, Stroh H, Bianchi DW, Johnson KL. Cervical cancer and microchimerism. Obstetrics and Gynecology. 2003 Oct 1;102(4):774-781. https://doi.org/10.1016/S0029-7844(03)00615-X