Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata

Trong Tuan Dao, Phi Hung Nguyen, Hong Sik Lee, Eunhee Kim, Junsoo Park, Seong Il Lim, Won Keun Oh

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The emergence of highly pathogenic influenza A virus strains, such as the new H1N1 swine influenza (novel influenza), represents a serious threat to global human health. During our course of an anti-influenza screening program on natural products, one new licochalcone G (1) and seven known (2-8) chalcones were isolated as active principles from the acetone extract of Glycyrrhiza inflata. Compounds 3 and 6 without prenyl group showed strong inhibitory effects on various neuraminidases from influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, the efficacy of oseltamivir with the presence of compound 3 (5 μM) was increased against H274Y neuraminidase. This evidence of synergistic effect makes this inhibitor to have a potential possibility for control of pandemic infection by oseltamivir-resistant influenza virus.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Chalcones
Oseltamivir
Glycyrrhiza
Neuraminidase
Human Influenza
Viruses
Acetone
Biological Products
HEK293 Cells
Influenza A virus
Screening
Pandemics
Infection Control
Orthomyxoviridae
Health
Swine
influenza A virus NA protein

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Dao, Trong Tuan ; Nguyen, Phi Hung ; Lee, Hong Sik ; Kim, Eunhee ; Park, Junsoo ; Lim, Seong Il ; Oh, Won Keun. / Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. In: Bioorganic and Medicinal Chemistry Letters. 2011 ; Vol. 21, No. 1. pp. 294-298.
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Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. / Dao, Trong Tuan; Nguyen, Phi Hung; Lee, Hong Sik; Kim, Eunhee; Park, Junsoo; Lim, Seong Il; Oh, Won Keun.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 1, 01.01.2011, p. 294-298.

Research output: Contribution to journalArticle

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