Chameleon-like self-assembling peptides for adaptable biorecognition nanohybrids

Woo Jin Jeong, Sung Ju Choi, Jun Shik Choi, Yong Beom Lim

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We present here the development of adaptable hybrid materials in which self-assembling peptides can sense the diameter/curvature of carbon nanotubes and then adjust their overall structures from disordered states to α-helices, and vice versa. The peptides within the hybrid materials show exceptionally high thermal-induced conformational stability and molecular recognition capability for target RNA. This study shows that the context-dependent protein-folding effects can be realized in artificial nanosystems and provides a proof of principle that nanohybrid materials decorated with structured and adjustable peptide units can be fabricated using our strategy, from which smart and responsive organic/inorganic hybrid materials capable of sensing and controlling diverse biological molecular recognition events can be developed.

Original languageEnglish
Pages (from-to)6850-6857
Number of pages8
JournalACS Nano
Volume7
Issue number8
DOIs
Publication statusPublished - 2013 Aug 27

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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