Change in international Prostate Symptom storage subscore after long-term medical therapy in BPH patients

Finasteride and alpha-blocker combination therapy in men with moderate-to-severe LUTS/BPH in Korea

Ji Youl Lee, Seung Hwan Lee, Su Jin Kim, Choung Soo Kim, Hyun Moo Lee, Cheon Il Kim, Byungha Chung

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To evaluate the efficacy and the change of International Prostate Symptom Score (IPSS) storage subscore after combination therapy (α-blocker and finasteride) in patients with lower urinary tract symptoms (LUTS) consistent with moderate-to-severe benign prostatic hyperplasia (BPH) and compared with α-blockeronly treatment. Methods: A total of 1315 patients seen in 5 urology centers in Korea from January 2001 to August 2007, with LUTS secondary to BPH were enrolled. Patients were divided into 4 groups according to treatment pattern (α-blocker monotherapy vs combination therapy) and IPSS storage subscores (<6 vs <6). The changes from baseline in prostate volume, prostate-specific antigen concentration, IPSS, and Qmax. were analyzed. We also determined the statistical differences among 4 groups in the IPSS, Qmax., quality of life score (QoL), and prostate volume. Results: Of the 1315 men, 217 (16.5%) completed the month 48 visit. All groups showed significant improvements in the IPSS total score, IPSS voiding subscores, and QoL at 1 year. However, the high storage subscore group at baseline showed a significantly higher improvement in IPSS total scores and IPSS voiding subscores compared with the low storage subscore group at year 4. IPSS storage subscores were improved only in patients with high storage subscores at baseline, especially in combination treatment group. The mean change in QoL score from baseline to year 4 was significantly improved in high storage subscore groups. Conclusions: Data from this retrospective analysis suggest that long-term combination treatment would be beneficial, especially to patients with severe storage symptoms at baseline.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalUrology
Volume77
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

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Finasteride
Lower Urinary Tract Symptoms
Prostatic Hyperplasia
Korea
Prostate
Therapeutics
Quality of Life
Urology
Prostate-Specific Antigen

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

@article{c2085408e63d4685919c3fa8432a9dbc,
title = "Change in international Prostate Symptom storage subscore after long-term medical therapy in BPH patients: Finasteride and alpha-blocker combination therapy in men with moderate-to-severe LUTS/BPH in Korea",
abstract = "Objective: To evaluate the efficacy and the change of International Prostate Symptom Score (IPSS) storage subscore after combination therapy (α-blocker and finasteride) in patients with lower urinary tract symptoms (LUTS) consistent with moderate-to-severe benign prostatic hyperplasia (BPH) and compared with α-blockeronly treatment. Methods: A total of 1315 patients seen in 5 urology centers in Korea from January 2001 to August 2007, with LUTS secondary to BPH were enrolled. Patients were divided into 4 groups according to treatment pattern (α-blocker monotherapy vs combination therapy) and IPSS storage subscores (<6 vs <6). The changes from baseline in prostate volume, prostate-specific antigen concentration, IPSS, and Qmax. were analyzed. We also determined the statistical differences among 4 groups in the IPSS, Qmax., quality of life score (QoL), and prostate volume. Results: Of the 1315 men, 217 (16.5{\%}) completed the month 48 visit. All groups showed significant improvements in the IPSS total score, IPSS voiding subscores, and QoL at 1 year. However, the high storage subscore group at baseline showed a significantly higher improvement in IPSS total scores and IPSS voiding subscores compared with the low storage subscore group at year 4. IPSS storage subscores were improved only in patients with high storage subscores at baseline, especially in combination treatment group. The mean change in QoL score from baseline to year 4 was significantly improved in high storage subscore groups. Conclusions: Data from this retrospective analysis suggest that long-term combination treatment would be beneficial, especially to patients with severe storage symptoms at baseline.",
author = "Lee, {Ji Youl} and Lee, {Seung Hwan} and Kim, {Su Jin} and Kim, {Choung Soo} and Lee, {Hyun Moo} and Kim, {Cheon Il} and Byungha Chung",
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Change in international Prostate Symptom storage subscore after long-term medical therapy in BPH patients : Finasteride and alpha-blocker combination therapy in men with moderate-to-severe LUTS/BPH in Korea. / Lee, Ji Youl; Lee, Seung Hwan; Kim, Su Jin; Kim, Choung Soo; Lee, Hyun Moo; Kim, Cheon Il; Chung, Byungha.

In: Urology, Vol. 77, No. 1, 01.01.2011, p. 171-176.

Research output: Contribution to journalArticle

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T2 - Finasteride and alpha-blocker combination therapy in men with moderate-to-severe LUTS/BPH in Korea

AU - Lee, Ji Youl

AU - Lee, Seung Hwan

AU - Kim, Su Jin

AU - Kim, Choung Soo

AU - Lee, Hyun Moo

AU - Kim, Cheon Il

AU - Chung, Byungha

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Objective: To evaluate the efficacy and the change of International Prostate Symptom Score (IPSS) storage subscore after combination therapy (α-blocker and finasteride) in patients with lower urinary tract symptoms (LUTS) consistent with moderate-to-severe benign prostatic hyperplasia (BPH) and compared with α-blockeronly treatment. Methods: A total of 1315 patients seen in 5 urology centers in Korea from January 2001 to August 2007, with LUTS secondary to BPH were enrolled. Patients were divided into 4 groups according to treatment pattern (α-blocker monotherapy vs combination therapy) and IPSS storage subscores (<6 vs <6). The changes from baseline in prostate volume, prostate-specific antigen concentration, IPSS, and Qmax. were analyzed. We also determined the statistical differences among 4 groups in the IPSS, Qmax., quality of life score (QoL), and prostate volume. Results: Of the 1315 men, 217 (16.5%) completed the month 48 visit. All groups showed significant improvements in the IPSS total score, IPSS voiding subscores, and QoL at 1 year. However, the high storage subscore group at baseline showed a significantly higher improvement in IPSS total scores and IPSS voiding subscores compared with the low storage subscore group at year 4. IPSS storage subscores were improved only in patients with high storage subscores at baseline, especially in combination treatment group. The mean change in QoL score from baseline to year 4 was significantly improved in high storage subscore groups. Conclusions: Data from this retrospective analysis suggest that long-term combination treatment would be beneficial, especially to patients with severe storage symptoms at baseline.

AB - Objective: To evaluate the efficacy and the change of International Prostate Symptom Score (IPSS) storage subscore after combination therapy (α-blocker and finasteride) in patients with lower urinary tract symptoms (LUTS) consistent with moderate-to-severe benign prostatic hyperplasia (BPH) and compared with α-blockeronly treatment. Methods: A total of 1315 patients seen in 5 urology centers in Korea from January 2001 to August 2007, with LUTS secondary to BPH were enrolled. Patients were divided into 4 groups according to treatment pattern (α-blocker monotherapy vs combination therapy) and IPSS storage subscores (<6 vs <6). The changes from baseline in prostate volume, prostate-specific antigen concentration, IPSS, and Qmax. were analyzed. We also determined the statistical differences among 4 groups in the IPSS, Qmax., quality of life score (QoL), and prostate volume. Results: Of the 1315 men, 217 (16.5%) completed the month 48 visit. All groups showed significant improvements in the IPSS total score, IPSS voiding subscores, and QoL at 1 year. However, the high storage subscore group at baseline showed a significantly higher improvement in IPSS total scores and IPSS voiding subscores compared with the low storage subscore group at year 4. IPSS storage subscores were improved only in patients with high storage subscores at baseline, especially in combination treatment group. The mean change in QoL score from baseline to year 4 was significantly improved in high storage subscore groups. Conclusions: Data from this retrospective analysis suggest that long-term combination treatment would be beneficial, especially to patients with severe storage symptoms at baseline.

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