TY - JOUR
T1 - Change in waist circumference and the progression of subclinical atherosclerosis in type 2 diabetes patients
AU - Nam, Ji Sun
AU - Cho, Minho
AU - Park, Jong Suk
AU - Ahn, Chul Woo
AU - Cha, Bong Soo
AU - Lee, Eun Jig
AU - Lim, Sung Kil
AU - Kim, Kyung Rae
AU - Lee, Hyun Chul
PY - 2011/7
Y1 - 2011/7
N2 - Objective: We aimed to assess the effect of reducing body weight, waist circumference, and various metabolic parameters on the progression of carotid intima media thickness (IMT) in Korean type 2 diabetes patients. Methods: This study comprised of 173 patients. Anthropometric measurements, metabolic parameters, and carotid IMT were measured at baseline and 1 year later. Results: There were significant differences in waist circumference, HbA1c, and mean left and right IMT after 1 year. The change in waist circumference correlated with changes in HbA1c and changes in right and left IMT after adjusting for age, sex, and medications that could influence the IMT. In multiple regression analysis, the change in waist circumference was a significant predictor of the progression of maximum right and left IMT, with a marginal significance for the latter, and mean left IMT, independent of changes in body weight, BMI, HbA1c level, and the use of anti-hyperlipidemic, antiplatelet agents and thiazolidinediones. Conclusion: Controlling abdominal obesity seems to have a significant impact on the progression of subclinical atherosclerosis in patients with diabetes, and therefore, more efforts should be made toward reducing waist circumference to inhibit overt atherosclerotic diseases.
AB - Objective: We aimed to assess the effect of reducing body weight, waist circumference, and various metabolic parameters on the progression of carotid intima media thickness (IMT) in Korean type 2 diabetes patients. Methods: This study comprised of 173 patients. Anthropometric measurements, metabolic parameters, and carotid IMT were measured at baseline and 1 year later. Results: There were significant differences in waist circumference, HbA1c, and mean left and right IMT after 1 year. The change in waist circumference correlated with changes in HbA1c and changes in right and left IMT after adjusting for age, sex, and medications that could influence the IMT. In multiple regression analysis, the change in waist circumference was a significant predictor of the progression of maximum right and left IMT, with a marginal significance for the latter, and mean left IMT, independent of changes in body weight, BMI, HbA1c level, and the use of anti-hyperlipidemic, antiplatelet agents and thiazolidinediones. Conclusion: Controlling abdominal obesity seems to have a significant impact on the progression of subclinical atherosclerosis in patients with diabetes, and therefore, more efforts should be made toward reducing waist circumference to inhibit overt atherosclerotic diseases.
UR - http://www.scopus.com/inward/record.url?scp=80051686358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051686358&partnerID=8YFLogxK
U2 - 10.1016/j.orcp.2011.01.003
DO - 10.1016/j.orcp.2011.01.003
M3 - Article
AN - SCOPUS:80051686358
SN - 1871-403X
VL - 5
SP - e202-e209
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
IS - 3
ER -
