Change in waist circumference and the progression of subclinical atherosclerosis in type 2 diabetes patients

Ji Sun Nam, Minho Cho, Jong Suk Park, Chul Woo Ahn, Bong Soo Cha, Eun Jig Lee, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee

Research output: Contribution to journalArticlepeer-review


Objective: We aimed to assess the effect of reducing body weight, waist circumference, and various metabolic parameters on the progression of carotid intima media thickness (IMT) in Korean type 2 diabetes patients. Methods: This study comprised of 173 patients. Anthropometric measurements, metabolic parameters, and carotid IMT were measured at baseline and 1 year later. Results: There were significant differences in waist circumference, HbA1c, and mean left and right IMT after 1 year. The change in waist circumference correlated with changes in HbA1c and changes in right and left IMT after adjusting for age, sex, and medications that could influence the IMT. In multiple regression analysis, the change in waist circumference was a significant predictor of the progression of maximum right and left IMT, with a marginal significance for the latter, and mean left IMT, independent of changes in body weight, BMI, HbA1c level, and the use of anti-hyperlipidemic, antiplatelet agents and thiazolidinediones. Conclusion: Controlling abdominal obesity seems to have a significant impact on the progression of subclinical atherosclerosis in patients with diabetes, and therefore, more efforts should be made toward reducing waist circumference to inhibit overt atherosclerotic diseases.

Original languageEnglish
Pages (from-to)e202-e209
JournalObesity Research and Clinical Practice
Issue number3
Publication statusPublished - 2011 Jul

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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