Changes in autonomic nervous system activity after treatment with alpha-blocker in men with lower urinary tract symptoms

Kang Hee Shim, Tae Woo Kim, Byungha Chung, Sung Won Lee, Jong Kwan Park, Kwangsung Park, Jun Cheon, Kyung Seop Lee, Hyung Jee Kim, Do Hwan Seong, Seung June Oh, Sae Woong Kim, Ji Youl Lee, Seol Ho Choo, Jong Bo Choi

Research output: Contribution to journalArticle

Abstract

Purpose: To determine changes in autonomic nervous system activity after treatment in men with lower urinary tract symptoms (LUTS), we evaluated changes in patients’ symptoms, uroflowmetry, and heart rate variability (HRV) after treatment with alphablockers for 12 weeks. Materials and Methods: Ninety-five men who had LUTS (International Prostate Symptom Score [IPSS] ≥8) were included in this study. We divided them into two groups on the basis of a low frequency/high frequency (LF/HF) ratio of 1.6. After treatment with Xatral XL (Handok Inc., Korea) 10 mg for 3 months, we rechecked their IPSS, uroflowmetry, HRV and compared these with the baseline measurements. Results: Fifty-four men were assigned to the low LF/HF group (group A: LF/HF ≤1.6) and 41 men to the high LF/HF group (group B: LF/HF >1.6). At baseline and 12 weeks, none of the parameters differed significantly between the groups except for HF, which is one of the parameters of HRV. IPSS, the IPSS-voiding subscore, and the IPSS-storage subscore decreased and maximal uroflow increased significantly after 12 weeks of treatment. Whereas the baseline LF/HF ratio increased from 0.89±0.407 to 1.80±1.804 after treatment in group A, it decreased from 3.93±5.471 to 1.79±1.153 in group B. Conclusions: The efficacies of Xatral XL were clear in both groups. We found that the LF/HF ratio in the two groups merged to a value of approximately 1.79 after treatment. We suggest that this could be a clue to the importance of balance in autonomic nervous system activity in men with LUTS.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalInvestigative and clinical urology
Volume59
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Lower Urinary Tract Symptoms
Autonomic Nervous System
Prostate
Heart Rate
Therapeutics
Korea

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Shim, Kang Hee ; Kim, Tae Woo ; Chung, Byungha ; Lee, Sung Won ; Park, Jong Kwan ; Park, Kwangsung ; Cheon, Jun ; Lee, Kyung Seop ; Kim, Hyung Jee ; Seong, Do Hwan ; Oh, Seung June ; Kim, Sae Woong ; Lee, Ji Youl ; Choo, Seol Ho ; Choi, Jong Bo. / Changes in autonomic nervous system activity after treatment with alpha-blocker in men with lower urinary tract symptoms. In: Investigative and clinical urology. 2018 ; Vol. 59, No. 1. pp. 49-54.
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abstract = "Purpose: To determine changes in autonomic nervous system activity after treatment in men with lower urinary tract symptoms (LUTS), we evaluated changes in patients’ symptoms, uroflowmetry, and heart rate variability (HRV) after treatment with alphablockers for 12 weeks. Materials and Methods: Ninety-five men who had LUTS (International Prostate Symptom Score [IPSS] ≥8) were included in this study. We divided them into two groups on the basis of a low frequency/high frequency (LF/HF) ratio of 1.6. After treatment with Xatral XL (Handok Inc., Korea) 10 mg for 3 months, we rechecked their IPSS, uroflowmetry, HRV and compared these with the baseline measurements. Results: Fifty-four men were assigned to the low LF/HF group (group A: LF/HF ≤1.6) and 41 men to the high LF/HF group (group B: LF/HF >1.6). At baseline and 12 weeks, none of the parameters differed significantly between the groups except for HF, which is one of the parameters of HRV. IPSS, the IPSS-voiding subscore, and the IPSS-storage subscore decreased and maximal uroflow increased significantly after 12 weeks of treatment. Whereas the baseline LF/HF ratio increased from 0.89±0.407 to 1.80±1.804 after treatment in group A, it decreased from 3.93±5.471 to 1.79±1.153 in group B. Conclusions: The efficacies of Xatral XL were clear in both groups. We found that the LF/HF ratio in the two groups merged to a value of approximately 1.79 after treatment. We suggest that this could be a clue to the importance of balance in autonomic nervous system activity in men with LUTS.",
author = "Shim, {Kang Hee} and Kim, {Tae Woo} and Byungha Chung and Lee, {Sung Won} and Park, {Jong Kwan} and Kwangsung Park and Jun Cheon and Lee, {Kyung Seop} and Kim, {Hyung Jee} and Seong, {Do Hwan} and Oh, {Seung June} and Kim, {Sae Woong} and Lee, {Ji Youl} and Choo, {Seol Ho} and Choi, {Jong Bo}",
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Shim, KH, Kim, TW, Chung, B, Lee, SW, Park, JK, Park, K, Cheon, J, Lee, KS, Kim, HJ, Seong, DH, Oh, SJ, Kim, SW, Lee, JY, Choo, SH & Choi, JB 2018, 'Changes in autonomic nervous system activity after treatment with alpha-blocker in men with lower urinary tract symptoms', Investigative and clinical urology, vol. 59, no. 1, pp. 49-54. https://doi.org/10.4111/icu.2018.59.1.49

Changes in autonomic nervous system activity after treatment with alpha-blocker in men with lower urinary tract symptoms. / Shim, Kang Hee; Kim, Tae Woo; Chung, Byungha; Lee, Sung Won; Park, Jong Kwan; Park, Kwangsung; Cheon, Jun; Lee, Kyung Seop; Kim, Hyung Jee; Seong, Do Hwan; Oh, Seung June; Kim, Sae Woong; Lee, Ji Youl; Choo, Seol Ho; Choi, Jong Bo.

In: Investigative and clinical urology, Vol. 59, No. 1, 01.01.2018, p. 49-54.

Research output: Contribution to journalArticle

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T1 - Changes in autonomic nervous system activity after treatment with alpha-blocker in men with lower urinary tract symptoms

AU - Shim, Kang Hee

AU - Kim, Tae Woo

AU - Chung, Byungha

AU - Lee, Sung Won

AU - Park, Jong Kwan

AU - Park, Kwangsung

AU - Cheon, Jun

AU - Lee, Kyung Seop

AU - Kim, Hyung Jee

AU - Seong, Do Hwan

AU - Oh, Seung June

AU - Kim, Sae Woong

AU - Lee, Ji Youl

AU - Choo, Seol Ho

AU - Choi, Jong Bo

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: To determine changes in autonomic nervous system activity after treatment in men with lower urinary tract symptoms (LUTS), we evaluated changes in patients’ symptoms, uroflowmetry, and heart rate variability (HRV) after treatment with alphablockers for 12 weeks. Materials and Methods: Ninety-five men who had LUTS (International Prostate Symptom Score [IPSS] ≥8) were included in this study. We divided them into two groups on the basis of a low frequency/high frequency (LF/HF) ratio of 1.6. After treatment with Xatral XL (Handok Inc., Korea) 10 mg for 3 months, we rechecked their IPSS, uroflowmetry, HRV and compared these with the baseline measurements. Results: Fifty-four men were assigned to the low LF/HF group (group A: LF/HF ≤1.6) and 41 men to the high LF/HF group (group B: LF/HF >1.6). At baseline and 12 weeks, none of the parameters differed significantly between the groups except for HF, which is one of the parameters of HRV. IPSS, the IPSS-voiding subscore, and the IPSS-storage subscore decreased and maximal uroflow increased significantly after 12 weeks of treatment. Whereas the baseline LF/HF ratio increased from 0.89±0.407 to 1.80±1.804 after treatment in group A, it decreased from 3.93±5.471 to 1.79±1.153 in group B. Conclusions: The efficacies of Xatral XL were clear in both groups. We found that the LF/HF ratio in the two groups merged to a value of approximately 1.79 after treatment. We suggest that this could be a clue to the importance of balance in autonomic nervous system activity in men with LUTS.

AB - Purpose: To determine changes in autonomic nervous system activity after treatment in men with lower urinary tract symptoms (LUTS), we evaluated changes in patients’ symptoms, uroflowmetry, and heart rate variability (HRV) after treatment with alphablockers for 12 weeks. Materials and Methods: Ninety-five men who had LUTS (International Prostate Symptom Score [IPSS] ≥8) were included in this study. We divided them into two groups on the basis of a low frequency/high frequency (LF/HF) ratio of 1.6. After treatment with Xatral XL (Handok Inc., Korea) 10 mg for 3 months, we rechecked their IPSS, uroflowmetry, HRV and compared these with the baseline measurements. Results: Fifty-four men were assigned to the low LF/HF group (group A: LF/HF ≤1.6) and 41 men to the high LF/HF group (group B: LF/HF >1.6). At baseline and 12 weeks, none of the parameters differed significantly between the groups except for HF, which is one of the parameters of HRV. IPSS, the IPSS-voiding subscore, and the IPSS-storage subscore decreased and maximal uroflow increased significantly after 12 weeks of treatment. Whereas the baseline LF/HF ratio increased from 0.89±0.407 to 1.80±1.804 after treatment in group A, it decreased from 3.93±5.471 to 1.79±1.153 in group B. Conclusions: The efficacies of Xatral XL were clear in both groups. We found that the LF/HF ratio in the two groups merged to a value of approximately 1.79 after treatment. We suggest that this could be a clue to the importance of balance in autonomic nervous system activity in men with LUTS.

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