Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients

Seung Kyu Park, Sunghee Hong, Seok Yong Eum, In Hee Lee, Donk Ok Shin, Jang Eun Cho, Sungae Cho, Sang Nae Cho

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The immune responses of multidrug-resistant tuberculosis (MDR-TB) patients undergoing lung resection surgery were investigated in order to understand the mechanism of strong immune suppression in MDR-TB. We examined changes in cell-mediated immune response (CMI) of a total of sixteen MDR-TB patients, three of them extensively drug-resistant tuberculosis (XDR-TB) patients, after the removal of the heavily diseased lung section. The IFN-γ response to Mycobacterium tuberculosis culture filtrate proteins (Mtb-CFP), one of the most important CMI to defend TB, showed a statistically significant elevation in 2-4 months after operation when compared to the preoperative CMI in patients who were converted into AFB negative and cured in two years' follow-up, suggesting that the recovery of CMI may be one of the key factors in the successful treatment of MDR-TB. Interestingly, IL-10 response to Mtb-CFP was also elevated in 2-4 months after surgery in cured patients although both proliferative response and PBMC composition were not significantly changed. Infection with first- or second-line drugs resistant Mtb reduces the efficiency of chemotherapeutic treatment of MDR-TB to about 50%. Thus, this study suggests that chemotherapeutic treatment of MDR-TB may be more effective when combined with accompanying therapy that increases CMI, includes lung resection surgery.

Original languageEnglish
Pages (from-to)300-307
Number of pages8
JournalTuberculosis
Volume91
Issue number4
DOIs
Publication statusPublished - 2011 Jul 1

Fingerprint

Multidrug-Resistant Tuberculosis
Lung
Extensively Drug-Resistant Tuberculosis
Mycobacterium tuberculosis
Cell- and Tissue-Based Therapy
Interleukin-10
Lung Diseases
Proteins
Therapeutics
Infection
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Park, Seung Kyu ; Hong, Sunghee ; Eum, Seok Yong ; Lee, In Hee ; Shin, Donk Ok ; Cho, Jang Eun ; Cho, Sungae ; Cho, Sang Nae. / Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients. In: Tuberculosis. 2011 ; Vol. 91, No. 4. pp. 300-307.
@article{bfa0f8150a7f4ce69cc8ac7802544bb9,
title = "Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients",
abstract = "The immune responses of multidrug-resistant tuberculosis (MDR-TB) patients undergoing lung resection surgery were investigated in order to understand the mechanism of strong immune suppression in MDR-TB. We examined changes in cell-mediated immune response (CMI) of a total of sixteen MDR-TB patients, three of them extensively drug-resistant tuberculosis (XDR-TB) patients, after the removal of the heavily diseased lung section. The IFN-γ response to Mycobacterium tuberculosis culture filtrate proteins (Mtb-CFP), one of the most important CMI to defend TB, showed a statistically significant elevation in 2-4 months after operation when compared to the preoperative CMI in patients who were converted into AFB negative and cured in two years' follow-up, suggesting that the recovery of CMI may be one of the key factors in the successful treatment of MDR-TB. Interestingly, IL-10 response to Mtb-CFP was also elevated in 2-4 months after surgery in cured patients although both proliferative response and PBMC composition were not significantly changed. Infection with first- or second-line drugs resistant Mtb reduces the efficiency of chemotherapeutic treatment of MDR-TB to about 50{\%}. Thus, this study suggests that chemotherapeutic treatment of MDR-TB may be more effective when combined with accompanying therapy that increases CMI, includes lung resection surgery.",
author = "Park, {Seung Kyu} and Sunghee Hong and Eum, {Seok Yong} and Lee, {In Hee} and Shin, {Donk Ok} and Cho, {Jang Eun} and Sungae Cho and Cho, {Sang Nae}",
year = "2011",
month = "7",
day = "1",
doi = "10.1016/j.tube.2011.02.003",
language = "English",
volume = "91",
pages = "300--307",
journal = "Tuberculosis",
issn = "1472-9792",
publisher = "Churchill Livingstone",
number = "4",

}

Park, SK, Hong, S, Eum, SY, Lee, IH, Shin, DO, Cho, JE, Cho, S & Cho, SN 2011, 'Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients', Tuberculosis, vol. 91, no. 4, pp. 300-307. https://doi.org/10.1016/j.tube.2011.02.003

Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients. / Park, Seung Kyu; Hong, Sunghee; Eum, Seok Yong; Lee, In Hee; Shin, Donk Ok; Cho, Jang Eun; Cho, Sungae; Cho, Sang Nae.

In: Tuberculosis, Vol. 91, No. 4, 01.07.2011, p. 300-307.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients

AU - Park, Seung Kyu

AU - Hong, Sunghee

AU - Eum, Seok Yong

AU - Lee, In Hee

AU - Shin, Donk Ok

AU - Cho, Jang Eun

AU - Cho, Sungae

AU - Cho, Sang Nae

PY - 2011/7/1

Y1 - 2011/7/1

N2 - The immune responses of multidrug-resistant tuberculosis (MDR-TB) patients undergoing lung resection surgery were investigated in order to understand the mechanism of strong immune suppression in MDR-TB. We examined changes in cell-mediated immune response (CMI) of a total of sixteen MDR-TB patients, three of them extensively drug-resistant tuberculosis (XDR-TB) patients, after the removal of the heavily diseased lung section. The IFN-γ response to Mycobacterium tuberculosis culture filtrate proteins (Mtb-CFP), one of the most important CMI to defend TB, showed a statistically significant elevation in 2-4 months after operation when compared to the preoperative CMI in patients who were converted into AFB negative and cured in two years' follow-up, suggesting that the recovery of CMI may be one of the key factors in the successful treatment of MDR-TB. Interestingly, IL-10 response to Mtb-CFP was also elevated in 2-4 months after surgery in cured patients although both proliferative response and PBMC composition were not significantly changed. Infection with first- or second-line drugs resistant Mtb reduces the efficiency of chemotherapeutic treatment of MDR-TB to about 50%. Thus, this study suggests that chemotherapeutic treatment of MDR-TB may be more effective when combined with accompanying therapy that increases CMI, includes lung resection surgery.

AB - The immune responses of multidrug-resistant tuberculosis (MDR-TB) patients undergoing lung resection surgery were investigated in order to understand the mechanism of strong immune suppression in MDR-TB. We examined changes in cell-mediated immune response (CMI) of a total of sixteen MDR-TB patients, three of them extensively drug-resistant tuberculosis (XDR-TB) patients, after the removal of the heavily diseased lung section. The IFN-γ response to Mycobacterium tuberculosis culture filtrate proteins (Mtb-CFP), one of the most important CMI to defend TB, showed a statistically significant elevation in 2-4 months after operation when compared to the preoperative CMI in patients who were converted into AFB negative and cured in two years' follow-up, suggesting that the recovery of CMI may be one of the key factors in the successful treatment of MDR-TB. Interestingly, IL-10 response to Mtb-CFP was also elevated in 2-4 months after surgery in cured patients although both proliferative response and PBMC composition were not significantly changed. Infection with first- or second-line drugs resistant Mtb reduces the efficiency of chemotherapeutic treatment of MDR-TB to about 50%. Thus, this study suggests that chemotherapeutic treatment of MDR-TB may be more effective when combined with accompanying therapy that increases CMI, includes lung resection surgery.

UR - http://www.scopus.com/inward/record.url?scp=79960285763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960285763&partnerID=8YFLogxK

U2 - 10.1016/j.tube.2011.02.003

DO - 10.1016/j.tube.2011.02.003

M3 - Article

C2 - 21514229

AN - SCOPUS:79960285763

VL - 91

SP - 300

EP - 307

JO - Tuberculosis

JF - Tuberculosis

SN - 1472-9792

IS - 4

ER -