Changes in echocardiographic parameters according to the rate of residual renal function decline in incident peritoneal dialysis patients

Hyang Mo Koo, Fa Mee Doh, Chan Ho Kim, Mi Jung Lee, Eun Jin Kim, Jae Hyun Han, Ji Suk Han, Dong Ryeol Ryu, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Tae Hyun Yoo, Shin Wook Kang

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Abstract

Residual renal function (RRF) is associated with left ventricular (LV) hypertrophy as well as all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease. However, no studies have yet examined the serial changes in echocardiographic findings according to the rate of RRF decline in incident dialysis patients. A total of 81 patients who started peritoneal dialysis (PD) between 2005 and 2012 at Yonsei University Health System, Seoul, South Korea, and who underwent baseline and follow-up echocardiography within the first year of PD were recruited. Patients were dichotomized into "faster" and "slower" RRF decline groups according to the median values of RRF decline slope (-1.60mL/min/y/1.73m 2). Baseline RRF and echocardiographic parameters were comparable between the 2 groups. During the first year of PD, there were no significant changes in LV end-diastolic volume index (LVEDVI), left atrial volume index (LAVI), or LV mass index (LVMI) in the "faster" RRT decline group, while these indices decreased in the "slower" RRT decline group. The rate of RRF decline was a significant determinant of 1-year changes in LVEDVI, LAVI, and LVMI. The linear mixed model further confirmed that there were significant differences in the changes in LVEDVI, LAVI, and LVMI between the 2 groups (P=0.047, 0.048, and 0.001, respectively). During a mean follow-up duration of 31.9 months, 4 (4.9%) patients died. Compared with the "slower" RRF decline group, CV composite (20.29/100 vs 7.18/100 patient-years [PY], P=0.098), technique failure (18.80/100 vs 4.19/100 PY, P=0.006), and PD peritonitis (15.73/100 vs 4.95/100 PY, P=0.064) developed more frequently in patients with "faster" RRF decline rate. On multivariate Cox regression analysis, patients with "faster" RRF decline rate showed 4.82-, 4.44-, and 7.37-fold higher risks, respectively, for each clinical outcome. Preservation of RRF is important for conserving cardiac performance, resulting in an improvement in clinical outcomes of incident PD patients.

Original languageEnglish
Pages (from-to)e427
JournalMedicine (United States)
Volume94
Issue number7
DOIs
Publication statusPublished - 2015 Feb 7

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Peritoneal Dialysis
Kidney
Republic of Korea
Left Ventricular Hypertrophy
Peritonitis
Stroke Volume
Chronic Kidney Failure
Echocardiography
Dialysis
Linear Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Koo, Hyang Mo ; Doh, Fa Mee ; Kim, Chan Ho ; Lee, Mi Jung ; Kim, Eun Jin ; Han, Jae Hyun ; Han, Ji Suk ; Ryu, Dong Ryeol ; Oh, Hyung Jung ; Park, Jung Tak ; Han, Seung Hyeok ; Yoo, Tae Hyun ; Kang, Shin Wook. / Changes in echocardiographic parameters according to the rate of residual renal function decline in incident peritoneal dialysis patients. In: Medicine (United States). 2015 ; Vol. 94, No. 7. pp. e427.
@article{01a0061687804b119492029cd0e88d31,
title = "Changes in echocardiographic parameters according to the rate of residual renal function decline in incident peritoneal dialysis patients",
abstract = "Residual renal function (RRF) is associated with left ventricular (LV) hypertrophy as well as all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease. However, no studies have yet examined the serial changes in echocardiographic findings according to the rate of RRF decline in incident dialysis patients. A total of 81 patients who started peritoneal dialysis (PD) between 2005 and 2012 at Yonsei University Health System, Seoul, South Korea, and who underwent baseline and follow-up echocardiography within the first year of PD were recruited. Patients were dichotomized into {"}faster{"} and {"}slower{"} RRF decline groups according to the median values of RRF decline slope (-1.60mL/min/y/1.73m 2). Baseline RRF and echocardiographic parameters were comparable between the 2 groups. During the first year of PD, there were no significant changes in LV end-diastolic volume index (LVEDVI), left atrial volume index (LAVI), or LV mass index (LVMI) in the {"}faster{"} RRT decline group, while these indices decreased in the {"}slower{"} RRT decline group. The rate of RRF decline was a significant determinant of 1-year changes in LVEDVI, LAVI, and LVMI. The linear mixed model further confirmed that there were significant differences in the changes in LVEDVI, LAVI, and LVMI between the 2 groups (P=0.047, 0.048, and 0.001, respectively). During a mean follow-up duration of 31.9 months, 4 (4.9{\%}) patients died. Compared with the {"}slower{"} RRF decline group, CV composite (20.29/100 vs 7.18/100 patient-years [PY], P=0.098), technique failure (18.80/100 vs 4.19/100 PY, P=0.006), and PD peritonitis (15.73/100 vs 4.95/100 PY, P=0.064) developed more frequently in patients with {"}faster{"} RRF decline rate. On multivariate Cox regression analysis, patients with {"}faster{"} RRF decline rate showed 4.82-, 4.44-, and 7.37-fold higher risks, respectively, for each clinical outcome. Preservation of RRF is important for conserving cardiac performance, resulting in an improvement in clinical outcomes of incident PD patients.",
author = "Koo, {Hyang Mo} and Doh, {Fa Mee} and Kim, {Chan Ho} and Lee, {Mi Jung} and Kim, {Eun Jin} and Han, {Jae Hyun} and Han, {Ji Suk} and Ryu, {Dong Ryeol} and Oh, {Hyung Jung} and Park, {Jung Tak} and Han, {Seung Hyeok} and Yoo, {Tae Hyun} and Kang, {Shin Wook}",
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Changes in echocardiographic parameters according to the rate of residual renal function decline in incident peritoneal dialysis patients. / Koo, Hyang Mo; Doh, Fa Mee; Kim, Chan Ho; Lee, Mi Jung; Kim, Eun Jin; Han, Jae Hyun; Han, Ji Suk; Ryu, Dong Ryeol; Oh, Hyung Jung; Park, Jung Tak; Han, Seung Hyeok; Yoo, Tae Hyun; Kang, Shin Wook.

In: Medicine (United States), Vol. 94, No. 7, 07.02.2015, p. e427.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in echocardiographic parameters according to the rate of residual renal function decline in incident peritoneal dialysis patients

AU - Koo, Hyang Mo

AU - Doh, Fa Mee

AU - Kim, Chan Ho

AU - Lee, Mi Jung

AU - Kim, Eun Jin

AU - Han, Jae Hyun

AU - Han, Ji Suk

AU - Ryu, Dong Ryeol

AU - Oh, Hyung Jung

AU - Park, Jung Tak

AU - Han, Seung Hyeok

AU - Yoo, Tae Hyun

AU - Kang, Shin Wook

PY - 2015/2/7

Y1 - 2015/2/7

N2 - Residual renal function (RRF) is associated with left ventricular (LV) hypertrophy as well as all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease. However, no studies have yet examined the serial changes in echocardiographic findings according to the rate of RRF decline in incident dialysis patients. A total of 81 patients who started peritoneal dialysis (PD) between 2005 and 2012 at Yonsei University Health System, Seoul, South Korea, and who underwent baseline and follow-up echocardiography within the first year of PD were recruited. Patients were dichotomized into "faster" and "slower" RRF decline groups according to the median values of RRF decline slope (-1.60mL/min/y/1.73m 2). Baseline RRF and echocardiographic parameters were comparable between the 2 groups. During the first year of PD, there were no significant changes in LV end-diastolic volume index (LVEDVI), left atrial volume index (LAVI), or LV mass index (LVMI) in the "faster" RRT decline group, while these indices decreased in the "slower" RRT decline group. The rate of RRF decline was a significant determinant of 1-year changes in LVEDVI, LAVI, and LVMI. The linear mixed model further confirmed that there were significant differences in the changes in LVEDVI, LAVI, and LVMI between the 2 groups (P=0.047, 0.048, and 0.001, respectively). During a mean follow-up duration of 31.9 months, 4 (4.9%) patients died. Compared with the "slower" RRF decline group, CV composite (20.29/100 vs 7.18/100 patient-years [PY], P=0.098), technique failure (18.80/100 vs 4.19/100 PY, P=0.006), and PD peritonitis (15.73/100 vs 4.95/100 PY, P=0.064) developed more frequently in patients with "faster" RRF decline rate. On multivariate Cox regression analysis, patients with "faster" RRF decline rate showed 4.82-, 4.44-, and 7.37-fold higher risks, respectively, for each clinical outcome. Preservation of RRF is important for conserving cardiac performance, resulting in an improvement in clinical outcomes of incident PD patients.

AB - Residual renal function (RRF) is associated with left ventricular (LV) hypertrophy as well as all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease. However, no studies have yet examined the serial changes in echocardiographic findings according to the rate of RRF decline in incident dialysis patients. A total of 81 patients who started peritoneal dialysis (PD) between 2005 and 2012 at Yonsei University Health System, Seoul, South Korea, and who underwent baseline and follow-up echocardiography within the first year of PD were recruited. Patients were dichotomized into "faster" and "slower" RRF decline groups according to the median values of RRF decline slope (-1.60mL/min/y/1.73m 2). Baseline RRF and echocardiographic parameters were comparable between the 2 groups. During the first year of PD, there were no significant changes in LV end-diastolic volume index (LVEDVI), left atrial volume index (LAVI), or LV mass index (LVMI) in the "faster" RRT decline group, while these indices decreased in the "slower" RRT decline group. The rate of RRF decline was a significant determinant of 1-year changes in LVEDVI, LAVI, and LVMI. The linear mixed model further confirmed that there were significant differences in the changes in LVEDVI, LAVI, and LVMI between the 2 groups (P=0.047, 0.048, and 0.001, respectively). During a mean follow-up duration of 31.9 months, 4 (4.9%) patients died. Compared with the "slower" RRF decline group, CV composite (20.29/100 vs 7.18/100 patient-years [PY], P=0.098), technique failure (18.80/100 vs 4.19/100 PY, P=0.006), and PD peritonitis (15.73/100 vs 4.95/100 PY, P=0.064) developed more frequently in patients with "faster" RRF decline rate. On multivariate Cox regression analysis, patients with "faster" RRF decline rate showed 4.82-, 4.44-, and 7.37-fold higher risks, respectively, for each clinical outcome. Preservation of RRF is important for conserving cardiac performance, resulting in an improvement in clinical outcomes of incident PD patients.

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