Changes in mechanical and bacterial properties of denture base resin following nanoceria incorporation with and without SBA-15 carriers

Utkarsh Mangal, Ji Young Seo, Jeong Hyun Ryu, Jie Jin, Chengzan Wu, Jung Yul Cha, Kee Joon Lee, Hyung Seog Yu, Kwang Mahn Kim, Jae Sung Kwon, Sung Hwan Choi

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Poly (methyl methacrylate) (PMMA) is a commonly used material for the fabrication of biomedical appliances. Although PMMA has several advantages, it is susceptible to microbial insults with practical use. Therefore, different bioactive nanomaterials, such as nanoceria (CeN), have been proposed to enhance the properties of PMMA. In this study, we investigated the effect of the incorporation of CeN into PMMA with and without the use of mesoporous silica nanoparticle (SBA-15) carriers. The unmodified PMMA specimens (control, CTRL) were compared to groups containing SBA-15, CeN, and the synthesized SBA-15 impregnated with CeN (SBA-15@CeN) at different loading percentages. The mechanical and physical properties of the different SBA-15@CeN groups and their effects on cell viability were investigated, and the optimal CeN concentration was identified accordingly. Our results revealed that flexural strength was significantly (P < 0.01) reduced in the SBA-15@CeN group (containing 3-fold the CeN wt. %). Although the surface microhardness increased with the increase in the wt. % of SBA-15@CeN, cell viability was significantly reduced (P < 0.001). The SBA-15@CeN group had the optimal concentration and displayed significant resistance to single-and multispecies microbial colonization. Finally, the enzymatic activity of CeN was significantly high in the SBA-15@CeN group. The proinflammatory markers (IL-6, IL-1β, TNF-α, CD80, and CD86) showed a significant (P < 0.001) multifold reduction in lipopolysaccharide-induced RAW cells treated with a 5-day eluate of the SBA-15@CeN group. These results indicate that the addition of SBA-15@CeN at 1.5 wt % improves the biological response of PMMA without compromising its mechanical properties.

Original languageEnglish
Article number105634
JournalJournal of the Mechanical Behavior of Biomedical Materials
Publication statusPublished - 2023 Feb

Bibliographical note

Funding Information:
This work was supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT , the Ministry of Trade, Industry and Energy , the Ministry of Health and Welfare , the Ministry of Food and Drug Safety ) (Project Number: KMDF_PR_20200901_0067–01 ), by the National Research Foundation of Korea (NRF) grant funded by the Korea government ( MSIT ) (No. 2021R1A2C2091260 ).

Publisher Copyright:
© 2022 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials


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