Changes in parvalbumin immunoreactivity in the parietofrontal cortex after transient forebrain ischemia in the mongolian gerbil

In Koo Hwang, Ki Yeon Yoo, Duk Soo Kim, Ju Young Jung, Kil Soo Kim, Jin Kyu Park, Youn Gen Kwon, Jae Yong Lee, Tae Cheon Kang, Moo Ho Won

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Abstract

We investigated the changes in parvalbumin (PV)-immunoreactive (IR) neurons in the parietofrontal cortex after transient forebrain ischemia. In the sham - operated group, PV-IR neurons were present in all layers of the parietofrontal cortex except layer I. Shortly after ischemia the number of PV-IR neurons in layer II/III first increased, and then declined dramatically 12 h after ischemic insult, followed by a second increase after 2 days. At this time the PV immunoreactivity was very weak and only present in the peripheral neuronal cytoplasm. The reversible increase in the number of PV-IR neurons and in the level of their immunoreactivity could result from a transient ischemia-induced increase in intracellular calcium. This pattern of expression was particularly pronounced in layer II/III of the parietofrontal cortex, suggesting that these neurons are especially susceptible to ischemic insult.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalMolecules and cells
Volume17
Issue number2
Publication statusPublished - 2004 Apr 30

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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    Hwang, I. K., Yoo, K. Y., Kim, D. S., Jung, J. Y., Kim, K. S., Park, J. K., Kwon, Y. G., Lee, J. Y., Kang, T. C., & Won, M. H. (2004). Changes in parvalbumin immunoreactivity in the parietofrontal cortex after transient forebrain ischemia in the mongolian gerbil. Molecules and cells, 17(2), 304-308.