Changes in periodontium after extraction of a periodontally-involved tooth in rats

Dong Ju Kim, Jae Kook Cha, Cheryl Yang, Ahran Cho, Jung Seok Lee, Ui Won Jung, Chang Sung Kim, Seung Jong Lee, Seong Ho Choi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Recent interest has focused on intentional replantation to restore an original tooth. Some studies have shown successful results with intentional replantation for periodontally involved teeth. For long-term success of replantation, a healthy periodontal status of the recipient site is required so that delayed replantation is more suitable for periodontally involved teeth. To reveal the ideal timing for delayed replantation of periodontally involved teeth, the healing process of extraction sockets after extraction of periodontitis-induced teeth in rats was evaluated. Methods: Twenty-eight rats were randomly divided into two groups: a control group (n=8) and test group (n=2o). In the test group, periodontitis was induced by a ligature around the cervix of the mandibular first molar of all of the rats. Two weeks later, the mandibular first molars were extracted in all of the animals. The animals were sacrificed on days o, 3,7, and 10 after extraction and histological and immunohistochemical analysis was performed. Results: In histological analysis of the test group, inflammatory cell infiltrate was found abundantly in the remaining periodontium 3 days after tooth extraction and decreased gradually at later time points. In immunohistochemical analysis of the test group, both interleukin-6 (IL-6) and, tumor necrosis factor-a (TNF-a) were numerous in the furcation area at each postextraction day. IL-6 was stained more heavily between 3 and 7 days after extraction; at day 10 after extraction, little staining was observed. TNF-a staining was more intense at 3 days after extraction and gradually weakened at later points in time. Conclusions: Within the limits of this study, it takes at least 10 days to resolve periodontal inflammation in rat extraction sockets.

Original languageEnglish
Pages (from-to)158-165
Number of pages8
JournalJournal of Periodontal and Implant Science
Volume42
Issue number5
DOIs
Publication statusPublished - 2012 Oct 1

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Periodontium
Replantation
Tooth
Periodontitis
Interleukin-6
Tumor Necrosis Factor-alpha
Staining and Labeling
Tooth Extraction
Cervix Uteri
Ligation
Inflammation
Control Groups

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Periodontics

Cite this

Kim, Dong Ju ; Cha, Jae Kook ; Yang, Cheryl ; Cho, Ahran ; Lee, Jung Seok ; Jung, Ui Won ; Kim, Chang Sung ; Lee, Seung Jong ; Choi, Seong Ho. / Changes in periodontium after extraction of a periodontally-involved tooth in rats. In: Journal of Periodontal and Implant Science. 2012 ; Vol. 42, No. 5. pp. 158-165.
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abstract = "Purpose: Recent interest has focused on intentional replantation to restore an original tooth. Some studies have shown successful results with intentional replantation for periodontally involved teeth. For long-term success of replantation, a healthy periodontal status of the recipient site is required so that delayed replantation is more suitable for periodontally involved teeth. To reveal the ideal timing for delayed replantation of periodontally involved teeth, the healing process of extraction sockets after extraction of periodontitis-induced teeth in rats was evaluated. Methods: Twenty-eight rats were randomly divided into two groups: a control group (n=8) and test group (n=2o). In the test group, periodontitis was induced by a ligature around the cervix of the mandibular first molar of all of the rats. Two weeks later, the mandibular first molars were extracted in all of the animals. The animals were sacrificed on days o, 3,7, and 10 after extraction and histological and immunohistochemical analysis was performed. Results: In histological analysis of the test group, inflammatory cell infiltrate was found abundantly in the remaining periodontium 3 days after tooth extraction and decreased gradually at later time points. In immunohistochemical analysis of the test group, both interleukin-6 (IL-6) and, tumor necrosis factor-a (TNF-a) were numerous in the furcation area at each postextraction day. IL-6 was stained more heavily between 3 and 7 days after extraction; at day 10 after extraction, little staining was observed. TNF-a staining was more intense at 3 days after extraction and gradually weakened at later points in time. Conclusions: Within the limits of this study, it takes at least 10 days to resolve periodontal inflammation in rat extraction sockets.",
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Changes in periodontium after extraction of a periodontally-involved tooth in rats. / Kim, Dong Ju; Cha, Jae Kook; Yang, Cheryl; Cho, Ahran; Lee, Jung Seok; Jung, Ui Won; Kim, Chang Sung; Lee, Seung Jong; Choi, Seong Ho.

In: Journal of Periodontal and Implant Science, Vol. 42, No. 5, 01.10.2012, p. 158-165.

Research output: Contribution to journalArticle

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AU - Cha, Jae Kook

AU - Yang, Cheryl

AU - Cho, Ahran

AU - Lee, Jung Seok

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AU - Kim, Chang Sung

AU - Lee, Seung Jong

AU - Choi, Seong Ho

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