Changes in serum and ascitic monocyte chemotactic protein-1 (MCP-1) and IL-10 levels in cirrhotic patients with spontaneous bacterial peritonitis

Ja Kyung Kim, Chae Yoon Chon, Jae Hak Kim, Yoon Jae Kim, Jae Hee Cho, Seung Min Bang, Sang Hoon Ahn, Kwang Hyub Han, Young Myoung Moon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Spontaneous bacterial peritonitis (SBP) is a prototypical infectious disease of cirrhotic patients. It has been suggested that cirrhotic patients' response to infection is less effective becaBse of differences in the inflammatory and immune reactions. This study aimed to investigate the expression of the inflammatory cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-10 (IL-10) in cirrhotic patients with SBP. The MCP-1 and IL-10 levels in the sera and ascitic fluids of cirrhotic patients with (n = 40) or without SBP (n = 17) were serially analyzed by ELISA. In the non-SBP group, the mean MCP-1 levels in sera and ascites were 53.0 ± 45.8 pg/mL and 197.5 ± 109.5 pg/mL, respectively, and the IL-10 levels were 10.9 ± 9.5 pg/mL and 77.6 ± 79.7 pg/mL, respectively. In the SBP group, the mean MCP-1 levels in serum and ascites before treatment were 164.7 ± 126.4 pg/mL and 365.3 ± 583.0 pg/mL, respectively, and the IL-10 levels were 31.4 ± 44.1 pg/mL and 188.1 ± 189.5 pg/mL, respectively. The sera MCP-1 and ascites IL-10 levels differed significantly between the two groups. In the SBP group, sera and ascitic MCP-1 and IL-10 levels fell during treatment. The low MCP-1 and IL-10 levels on the seventh day of treatment were found to have a statistically significant relationship to patient survival. MCP-1 and IL-10 levels in sera and ascites may be related to the clinical course of SBP.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalJournal of Interferon and Cytokine Research
Volume27
Issue number3
DOIs
Publication statusPublished - 2007 Mar 1

Fingerprint

Chemokine CCL2
Peritonitis
Interleukin-10
Serum
Ascites
Ascitic Fluid
Communicable Diseases
Blood Proteins
Therapeutics
Enzyme-Linked Immunosorbent Assay
Cytokines
Survival
Infection

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology
  • Virology

Cite this

Kim, Ja Kyung ; Chon, Chae Yoon ; Kim, Jae Hak ; Kim, Yoon Jae ; Cho, Jae Hee ; Bang, Seung Min ; Ahn, Sang Hoon ; Han, Kwang Hyub ; Moon, Young Myoung. / Changes in serum and ascitic monocyte chemotactic protein-1 (MCP-1) and IL-10 levels in cirrhotic patients with spontaneous bacterial peritonitis. In: Journal of Interferon and Cytokine Research. 2007 ; Vol. 27, No. 3. pp. 227-230.
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abstract = "Spontaneous bacterial peritonitis (SBP) is a prototypical infectious disease of cirrhotic patients. It has been suggested that cirrhotic patients' response to infection is less effective becaBse of differences in the inflammatory and immune reactions. This study aimed to investigate the expression of the inflammatory cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-10 (IL-10) in cirrhotic patients with SBP. The MCP-1 and IL-10 levels in the sera and ascitic fluids of cirrhotic patients with (n = 40) or without SBP (n = 17) were serially analyzed by ELISA. In the non-SBP group, the mean MCP-1 levels in sera and ascites were 53.0 ± 45.8 pg/mL and 197.5 ± 109.5 pg/mL, respectively, and the IL-10 levels were 10.9 ± 9.5 pg/mL and 77.6 ± 79.7 pg/mL, respectively. In the SBP group, the mean MCP-1 levels in serum and ascites before treatment were 164.7 ± 126.4 pg/mL and 365.3 ± 583.0 pg/mL, respectively, and the IL-10 levels were 31.4 ± 44.1 pg/mL and 188.1 ± 189.5 pg/mL, respectively. The sera MCP-1 and ascites IL-10 levels differed significantly between the two groups. In the SBP group, sera and ascitic MCP-1 and IL-10 levels fell during treatment. The low MCP-1 and IL-10 levels on the seventh day of treatment were found to have a statistically significant relationship to patient survival. MCP-1 and IL-10 levels in sera and ascites may be related to the clinical course of SBP.",
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Changes in serum and ascitic monocyte chemotactic protein-1 (MCP-1) and IL-10 levels in cirrhotic patients with spontaneous bacterial peritonitis. / Kim, Ja Kyung; Chon, Chae Yoon; Kim, Jae Hak; Kim, Yoon Jae; Cho, Jae Hee; Bang, Seung Min; Ahn, Sang Hoon; Han, Kwang Hyub; Moon, Young Myoung.

In: Journal of Interferon and Cytokine Research, Vol. 27, No. 3, 01.03.2007, p. 227-230.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes in serum and ascitic monocyte chemotactic protein-1 (MCP-1) and IL-10 levels in cirrhotic patients with spontaneous bacterial peritonitis

AU - Kim, Ja Kyung

AU - Chon, Chae Yoon

AU - Kim, Jae Hak

AU - Kim, Yoon Jae

AU - Cho, Jae Hee

AU - Bang, Seung Min

AU - Ahn, Sang Hoon

AU - Han, Kwang Hyub

AU - Moon, Young Myoung

PY - 2007/3/1

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N2 - Spontaneous bacterial peritonitis (SBP) is a prototypical infectious disease of cirrhotic patients. It has been suggested that cirrhotic patients' response to infection is less effective becaBse of differences in the inflammatory and immune reactions. This study aimed to investigate the expression of the inflammatory cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-10 (IL-10) in cirrhotic patients with SBP. The MCP-1 and IL-10 levels in the sera and ascitic fluids of cirrhotic patients with (n = 40) or without SBP (n = 17) were serially analyzed by ELISA. In the non-SBP group, the mean MCP-1 levels in sera and ascites were 53.0 ± 45.8 pg/mL and 197.5 ± 109.5 pg/mL, respectively, and the IL-10 levels were 10.9 ± 9.5 pg/mL and 77.6 ± 79.7 pg/mL, respectively. In the SBP group, the mean MCP-1 levels in serum and ascites before treatment were 164.7 ± 126.4 pg/mL and 365.3 ± 583.0 pg/mL, respectively, and the IL-10 levels were 31.4 ± 44.1 pg/mL and 188.1 ± 189.5 pg/mL, respectively. The sera MCP-1 and ascites IL-10 levels differed significantly between the two groups. In the SBP group, sera and ascitic MCP-1 and IL-10 levels fell during treatment. The low MCP-1 and IL-10 levels on the seventh day of treatment were found to have a statistically significant relationship to patient survival. MCP-1 and IL-10 levels in sera and ascites may be related to the clinical course of SBP.

AB - Spontaneous bacterial peritonitis (SBP) is a prototypical infectious disease of cirrhotic patients. It has been suggested that cirrhotic patients' response to infection is less effective becaBse of differences in the inflammatory and immune reactions. This study aimed to investigate the expression of the inflammatory cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-10 (IL-10) in cirrhotic patients with SBP. The MCP-1 and IL-10 levels in the sera and ascitic fluids of cirrhotic patients with (n = 40) or without SBP (n = 17) were serially analyzed by ELISA. In the non-SBP group, the mean MCP-1 levels in sera and ascites were 53.0 ± 45.8 pg/mL and 197.5 ± 109.5 pg/mL, respectively, and the IL-10 levels were 10.9 ± 9.5 pg/mL and 77.6 ± 79.7 pg/mL, respectively. In the SBP group, the mean MCP-1 levels in serum and ascites before treatment were 164.7 ± 126.4 pg/mL and 365.3 ± 583.0 pg/mL, respectively, and the IL-10 levels were 31.4 ± 44.1 pg/mL and 188.1 ± 189.5 pg/mL, respectively. The sera MCP-1 and ascites IL-10 levels differed significantly between the two groups. In the SBP group, sera and ascitic MCP-1 and IL-10 levels fell during treatment. The low MCP-1 and IL-10 levels on the seventh day of treatment were found to have a statistically significant relationship to patient survival. MCP-1 and IL-10 levels in sera and ascites may be related to the clinical course of SBP.

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