Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A

Su Hyeon Lee, Se Mi Kang, Man Ho Choi, Jeongae Lee, Mi Jung Park, Shin Hye Kim, Won Yong Lee, Jongki Hong, Bong Chul Chung

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Precocious puberty (PP) refers to the appearance of physical and hormonal signs of pubertal development at an abnormally early age. Urinary steroid signatures obtained from 42 patients with central PP and 40 patients with peripheral PP were assessed to compare metabolic changes. Levels of androgens such as testosterone, androstenedione, androstenediol, 16α-hydroxy-dehydroepiandrosterone, and 5α-androstenedione tended to be high in both PP groups, and the level of 17β-estradiol was higher in the central-PP group (P< 0.01) than in the peripheral-PP and 32 age-matched healthy girls. Altered steroid metabolism was also associated with urinary BPA levels, and levels of testosterone, 17β-estradiol, and pregnenolone were significantly increased among individuals with high BPA levels. In particular, a correlation was observed between estrogen metabolism and BPA levels irrespective of the type of PP. These findings suggest that in girls, BPA exposure causes metabolic changes in steroidogenesis, but not the early onset of PP.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalReproductive Toxicology
Volume44
DOIs
Publication statusPublished - 2014 Apr

All Science Journal Classification (ASJC) codes

  • Toxicology

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