Changes in subcortical structures in early- versus late-onset Alzheimer's disease

Hanna Cho, Sang Won Seo, Jeong Hun Kim, Changsoo Kim, Byoung Seok Ye, Geon Ha Kim, Young Noh, Hee Jin Kim, Cindy W. Yoon, Joon Kyung Seong, Chang Hun Kim, Sue J. Kang, Juhee Chin, Sung Tae Kim, Kyung Han Lee, Duk L. Na

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age.

Original languageEnglish
Pages (from-to)1740-1747
Number of pages8
JournalNeurobiology of Aging
Volume34
Issue number7
DOIs
Publication statusPublished - 2013 Jul 1

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Alzheimer Disease
Thalamus
Putamen
Cognitive Reserve
Globus Pallidus
Caudate Nucleus
Amygdala
Basal Ganglia
Age of Onset
Neuroimaging
Hippocampus

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Cho, Hanna ; Seo, Sang Won ; Kim, Jeong Hun ; Kim, Changsoo ; Ye, Byoung Seok ; Kim, Geon Ha ; Noh, Young ; Kim, Hee Jin ; Yoon, Cindy W. ; Seong, Joon Kyung ; Kim, Chang Hun ; Kang, Sue J. ; Chin, Juhee ; Kim, Sung Tae ; Lee, Kyung Han ; Na, Duk L. / Changes in subcortical structures in early- versus late-onset Alzheimer's disease. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 7. pp. 1740-1747.
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Cho, H, Seo, SW, Kim, JH, Kim, C, Ye, BS, Kim, GH, Noh, Y, Kim, HJ, Yoon, CW, Seong, JK, Kim, CH, Kang, SJ, Chin, J, Kim, ST, Lee, KH & Na, DL 2013, 'Changes in subcortical structures in early- versus late-onset Alzheimer's disease', Neurobiology of Aging, vol. 34, no. 7, pp. 1740-1747. https://doi.org/10.1016/j.neurobiolaging.2013.01.001

Changes in subcortical structures in early- versus late-onset Alzheimer's disease. / Cho, Hanna; Seo, Sang Won; Kim, Jeong Hun; Kim, Changsoo; Ye, Byoung Seok; Kim, Geon Ha; Noh, Young; Kim, Hee Jin; Yoon, Cindy W.; Seong, Joon Kyung; Kim, Chang Hun; Kang, Sue J.; Chin, Juhee; Kim, Sung Tae; Lee, Kyung Han; Na, Duk L.

In: Neurobiology of Aging, Vol. 34, No. 7, 01.07.2013, p. 1740-1747.

Research output: Contribution to journalArticle

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AU - Cho, Hanna

AU - Seo, Sang Won

AU - Kim, Jeong Hun

AU - Kim, Changsoo

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AU - Kim, Geon Ha

AU - Noh, Young

AU - Kim, Hee Jin

AU - Yoon, Cindy W.

AU - Seong, Joon Kyung

AU - Kim, Chang Hun

AU - Kang, Sue J.

AU - Chin, Juhee

AU - Kim, Sung Tae

AU - Lee, Kyung Han

AU - Na, Duk L.

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N2 - Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age.

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