Changes in the blood-brain barrier status closely correlate with the rate of disease progression in patients with multiple system atrophy: A longitudinal study

Ji E. Lee, Sook K. Song, Jin Yong Hong, Mun Kyung Sunwoo, Hyun Jung Park, Young H. Sohn, Phil Hyu Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)


Background: The pathomechanisms responsible for disease progression in multiple system atrophy are unknown. The blood-brain barrier status may act as a modifier of disease progression in neurodegenerative diseases. Methods: We evaluated the 12-month longitudinal change of the blood-brain barrier in 16 multiple system atrophy patients and analyzed its correlation with changes in clinical severity. Results: The baseline blood-brain barrier index did not correlate significantly with change in disease severity. However, changes in the blood-brain barrier indices over 12 months had significant positive correlations with changes in total unified multiple system atrophy rating scale (r = 0.56, p = 0.024) and part II scores (r = 0.56, p = 0.025). These correlation coefficients were higher after adjusting for baseline neurological deficits. Conclusions: These data suggest that changes in the blood-brain barrier status are closely coupled with the rate of disease progression in multiple system atrophy, potentially acting as a contributor to disease progression.

Original languageEnglish
Pages (from-to)450-452
Number of pages3
JournalParkinsonism and Related Disorders
Issue number4
Publication statusPublished - 2013 Apr 1


All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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