Changes in the clinical outcomes of variceal bleeding in cirrhotic patients: A 10-year experience in Gangwon Province, South Korea

Young Don Kim, Gab Jin Cheon, Moon Young Kim, Ki Tae Suk, Soon Koo Baik, Dong Joon Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Aims: Variceal rupture is one of the main causes of mortality in cirrhotic patients. However, there are limited data on the long-term outcomes of variceal bleeding. Methods: We investigated the incidence and mortality of variceal bleeding at three endoscopic centers in Gangwon province during 3 periods (August 1996 to July 1997, August 2001 to July 2002, and August 2006 to July 2007). Results: A total of 1,704 upper gastrointestinal (GI) bleedings occurred during the study periods. Peptic ulcers were found in 825 patients (48.5%), and variceal ruptures were found in 607 patients (35.6%). The variceal bleeding rate did not decrease in each period (26.0% vs 43.7% vs 33.9%, respectively). In the variceal bleeding group, the 6-week mortality rate steadily and significantly decreased (15.5% vs 10.8% vs 6.4%, respectively, p=0.027). In addition, the mortality rate was significantly higher in the variceal bleeding group than in the non-variceal bleeding group (10.4% vs 2.0%, p<0.001; odds ratio, 5.659; 95% confidence interval, 3.445 to 9.295). Conclusions: Variceal bleeding was still the major cause of upper GI bleedings and did not decrease in prevalence over the 10-year period in Gangwon province, South Korea. However, the mortality rate of variceal bleeding decreased significantly.

Original languageEnglish
Pages (from-to)476-481
Number of pages6
JournalGut and liver
Volume6
Issue number4
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Republic of Korea
antineoplaston A10
Hemorrhage
Mortality
Rupture
Peptic Ulcer
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{4296f078043149f79bb88cd673d46375,
title = "Changes in the clinical outcomes of variceal bleeding in cirrhotic patients: A 10-year experience in Gangwon Province, South Korea",
abstract = "Background/Aims: Variceal rupture is one of the main causes of mortality in cirrhotic patients. However, there are limited data on the long-term outcomes of variceal bleeding. Methods: We investigated the incidence and mortality of variceal bleeding at three endoscopic centers in Gangwon province during 3 periods (August 1996 to July 1997, August 2001 to July 2002, and August 2006 to July 2007). Results: A total of 1,704 upper gastrointestinal (GI) bleedings occurred during the study periods. Peptic ulcers were found in 825 patients (48.5{\%}), and variceal ruptures were found in 607 patients (35.6{\%}). The variceal bleeding rate did not decrease in each period (26.0{\%} vs 43.7{\%} vs 33.9{\%}, respectively). In the variceal bleeding group, the 6-week mortality rate steadily and significantly decreased (15.5{\%} vs 10.8{\%} vs 6.4{\%}, respectively, p=0.027). In addition, the mortality rate was significantly higher in the variceal bleeding group than in the non-variceal bleeding group (10.4{\%} vs 2.0{\%}, p<0.001; odds ratio, 5.659; 95{\%} confidence interval, 3.445 to 9.295). Conclusions: Variceal bleeding was still the major cause of upper GI bleedings and did not decrease in prevalence over the 10-year period in Gangwon province, South Korea. However, the mortality rate of variceal bleeding decreased significantly.",
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Changes in the clinical outcomes of variceal bleeding in cirrhotic patients : A 10-year experience in Gangwon Province, South Korea. / Kim, Young Don; Cheon, Gab Jin; Kim, Moon Young; Suk, Ki Tae; Baik, Soon Koo; Kim, Dong Joon.

In: Gut and liver, Vol. 6, No. 4, 01.10.2012, p. 476-481.

Research output: Contribution to journalArticle

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T1 - Changes in the clinical outcomes of variceal bleeding in cirrhotic patients

T2 - A 10-year experience in Gangwon Province, South Korea

AU - Kim, Young Don

AU - Cheon, Gab Jin

AU - Kim, Moon Young

AU - Suk, Ki Tae

AU - Baik, Soon Koo

AU - Kim, Dong Joon

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Background/Aims: Variceal rupture is one of the main causes of mortality in cirrhotic patients. However, there are limited data on the long-term outcomes of variceal bleeding. Methods: We investigated the incidence and mortality of variceal bleeding at three endoscopic centers in Gangwon province during 3 periods (August 1996 to July 1997, August 2001 to July 2002, and August 2006 to July 2007). Results: A total of 1,704 upper gastrointestinal (GI) bleedings occurred during the study periods. Peptic ulcers were found in 825 patients (48.5%), and variceal ruptures were found in 607 patients (35.6%). The variceal bleeding rate did not decrease in each period (26.0% vs 43.7% vs 33.9%, respectively). In the variceal bleeding group, the 6-week mortality rate steadily and significantly decreased (15.5% vs 10.8% vs 6.4%, respectively, p=0.027). In addition, the mortality rate was significantly higher in the variceal bleeding group than in the non-variceal bleeding group (10.4% vs 2.0%, p<0.001; odds ratio, 5.659; 95% confidence interval, 3.445 to 9.295). Conclusions: Variceal bleeding was still the major cause of upper GI bleedings and did not decrease in prevalence over the 10-year period in Gangwon province, South Korea. However, the mortality rate of variceal bleeding decreased significantly.

AB - Background/Aims: Variceal rupture is one of the main causes of mortality in cirrhotic patients. However, there are limited data on the long-term outcomes of variceal bleeding. Methods: We investigated the incidence and mortality of variceal bleeding at three endoscopic centers in Gangwon province during 3 periods (August 1996 to July 1997, August 2001 to July 2002, and August 2006 to July 2007). Results: A total of 1,704 upper gastrointestinal (GI) bleedings occurred during the study periods. Peptic ulcers were found in 825 patients (48.5%), and variceal ruptures were found in 607 patients (35.6%). The variceal bleeding rate did not decrease in each period (26.0% vs 43.7% vs 33.9%, respectively). In the variceal bleeding group, the 6-week mortality rate steadily and significantly decreased (15.5% vs 10.8% vs 6.4%, respectively, p=0.027). In addition, the mortality rate was significantly higher in the variceal bleeding group than in the non-variceal bleeding group (10.4% vs 2.0%, p<0.001; odds ratio, 5.659; 95% confidence interval, 3.445 to 9.295). Conclusions: Variceal bleeding was still the major cause of upper GI bleedings and did not decrease in prevalence over the 10-year period in Gangwon province, South Korea. However, the mortality rate of variceal bleeding decreased significantly.

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