Changing prevalence of glomerular diseases in Korean adults

A review of 20 years of experience

Jae Hyun Chang, Dong Ki Kim, Hyun Wook Kim, Sun Young Park, TaeHyun Yoo, Beom Seok Kim, Shin-Wook Kang, Kyu Hun Choi, Dae Suk Han, Heon Joo Jeong, Ho Yung Lee

Research output: Contribution to journalArticle

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Abstract

Background. The prevalence of glomerular diseases differs according to geographic area, race, age and indications for a renal biopsy. This study was conducted to evaluate the distribution and changing patterns of renal diseases during the past 20 years in a large patient population in Korea.Methods. Patients aged 16 years or older who underwent a renal biopsy at Severance Hospital in the Yonsei University Health System from 1987 to 2006 were enrolled. All medical records were reviewed retrospectively.Results. In total, 1818 patients (M:F = 1.02:1) were reviewed. Glomerulonephritis (GN) comprised 85.9 of the total biopsied cases. The most common primary GN was IgA nephropathy (IgAN) (28.3), which was followed by minimal change disease (MCD) (15.5), membranous nephropathy (MN) (12.3), focal segmental glomerulosclerosis (FSGS) (5.6) and membranoproliferative GN (MPGN) (4.0). The most common secondary GN was lupus nephritis (8.7). The most common idiopathic nephrotic syndrome was MCD (38.5), which was followed by MN and IgAN. Among 128 (7.4) patients who were HBsAg-positive, MN (30.5) and MPGN (21.1) were the most common GN. When the incidence rates between 1987-91 and 2002-06 were compared, IgAN increased from 25.6 to 34.5, while MCD (from 23.2 to 7.0) and MPGN (from 6.7 to 1.7) decreased significantly (P < 0.01).Conclusions. IgAN was the most common primary GN, and MCD was the most common cause of nephrotic syndrome. In the 5-year quartile comparison, the relative frequency of IgAN increased, while the relative frequency of MCD and MPGN decreased significantly during the past 20 years.

Original languageEnglish
Pages (from-to)2406-2410
Number of pages5
JournalNephrology Dialysis Transplantation
Volume24
Issue number8
DOIs
Publication statusPublished - 2009 Aug 1

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Lipoid Nephrosis
Glomerulonephritis
Immunoglobulin A
Membranous Glomerulonephritis
Kidney
Membranoproliferative Glomerulonephritis
Biopsy
Focal Segmental Glomerulosclerosis
Lupus Nephritis
Nephrotic Syndrome
Korea
Hepatitis B Surface Antigens
Medical Records
Incidence
Health
Population

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Chang, Jae Hyun ; Kim, Dong Ki ; Kim, Hyun Wook ; Park, Sun Young ; Yoo, TaeHyun ; Kim, Beom Seok ; Kang, Shin-Wook ; Choi, Kyu Hun ; Han, Dae Suk ; Jeong, Heon Joo ; Lee, Ho Yung. / Changing prevalence of glomerular diseases in Korean adults : A review of 20 years of experience. In: Nephrology Dialysis Transplantation. 2009 ; Vol. 24, No. 8. pp. 2406-2410.
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title = "Changing prevalence of glomerular diseases in Korean adults: A review of 20 years of experience",
abstract = "Background. The prevalence of glomerular diseases differs according to geographic area, race, age and indications for a renal biopsy. This study was conducted to evaluate the distribution and changing patterns of renal diseases during the past 20 years in a large patient population in Korea.Methods. Patients aged 16 years or older who underwent a renal biopsy at Severance Hospital in the Yonsei University Health System from 1987 to 2006 were enrolled. All medical records were reviewed retrospectively.Results. In total, 1818 patients (M:F = 1.02:1) were reviewed. Glomerulonephritis (GN) comprised 85.9 of the total biopsied cases. The most common primary GN was IgA nephropathy (IgAN) (28.3), which was followed by minimal change disease (MCD) (15.5), membranous nephropathy (MN) (12.3), focal segmental glomerulosclerosis (FSGS) (5.6) and membranoproliferative GN (MPGN) (4.0). The most common secondary GN was lupus nephritis (8.7). The most common idiopathic nephrotic syndrome was MCD (38.5), which was followed by MN and IgAN. Among 128 (7.4) patients who were HBsAg-positive, MN (30.5) and MPGN (21.1) were the most common GN. When the incidence rates between 1987-91 and 2002-06 were compared, IgAN increased from 25.6 to 34.5, while MCD (from 23.2 to 7.0) and MPGN (from 6.7 to 1.7) decreased significantly (P < 0.01).Conclusions. IgAN was the most common primary GN, and MCD was the most common cause of nephrotic syndrome. In the 5-year quartile comparison, the relative frequency of IgAN increased, while the relative frequency of MCD and MPGN decreased significantly during the past 20 years.",
author = "Chang, {Jae Hyun} and Kim, {Dong Ki} and Kim, {Hyun Wook} and Park, {Sun Young} and TaeHyun Yoo and Kim, {Beom Seok} and Shin-Wook Kang and Choi, {Kyu Hun} and Han, {Dae Suk} and Jeong, {Heon Joo} and Lee, {Ho Yung}",
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Chang, JH, Kim, DK, Kim, HW, Park, SY, Yoo, T, Kim, BS, Kang, S-W, Choi, KH, Han, DS, Jeong, HJ & Lee, HY 2009, 'Changing prevalence of glomerular diseases in Korean adults: A review of 20 years of experience', Nephrology Dialysis Transplantation, vol. 24, no. 8, pp. 2406-2410. https://doi.org/10.1093/ndt/gfp091

Changing prevalence of glomerular diseases in Korean adults : A review of 20 years of experience. / Chang, Jae Hyun; Kim, Dong Ki; Kim, Hyun Wook; Park, Sun Young; Yoo, TaeHyun; Kim, Beom Seok; Kang, Shin-Wook; Choi, Kyu Hun; Han, Dae Suk; Jeong, Heon Joo; Lee, Ho Yung.

In: Nephrology Dialysis Transplantation, Vol. 24, No. 8, 01.08.2009, p. 2406-2410.

Research output: Contribution to journalArticle

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T1 - Changing prevalence of glomerular diseases in Korean adults

T2 - A review of 20 years of experience

AU - Chang, Jae Hyun

AU - Kim, Dong Ki

AU - Kim, Hyun Wook

AU - Park, Sun Young

AU - Yoo, TaeHyun

AU - Kim, Beom Seok

AU - Kang, Shin-Wook

AU - Choi, Kyu Hun

AU - Han, Dae Suk

AU - Jeong, Heon Joo

AU - Lee, Ho Yung

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background. The prevalence of glomerular diseases differs according to geographic area, race, age and indications for a renal biopsy. This study was conducted to evaluate the distribution and changing patterns of renal diseases during the past 20 years in a large patient population in Korea.Methods. Patients aged 16 years or older who underwent a renal biopsy at Severance Hospital in the Yonsei University Health System from 1987 to 2006 were enrolled. All medical records were reviewed retrospectively.Results. In total, 1818 patients (M:F = 1.02:1) were reviewed. Glomerulonephritis (GN) comprised 85.9 of the total biopsied cases. The most common primary GN was IgA nephropathy (IgAN) (28.3), which was followed by minimal change disease (MCD) (15.5), membranous nephropathy (MN) (12.3), focal segmental glomerulosclerosis (FSGS) (5.6) and membranoproliferative GN (MPGN) (4.0). The most common secondary GN was lupus nephritis (8.7). The most common idiopathic nephrotic syndrome was MCD (38.5), which was followed by MN and IgAN. Among 128 (7.4) patients who were HBsAg-positive, MN (30.5) and MPGN (21.1) were the most common GN. When the incidence rates between 1987-91 and 2002-06 were compared, IgAN increased from 25.6 to 34.5, while MCD (from 23.2 to 7.0) and MPGN (from 6.7 to 1.7) decreased significantly (P < 0.01).Conclusions. IgAN was the most common primary GN, and MCD was the most common cause of nephrotic syndrome. In the 5-year quartile comparison, the relative frequency of IgAN increased, while the relative frequency of MCD and MPGN decreased significantly during the past 20 years.

AB - Background. The prevalence of glomerular diseases differs according to geographic area, race, age and indications for a renal biopsy. This study was conducted to evaluate the distribution and changing patterns of renal diseases during the past 20 years in a large patient population in Korea.Methods. Patients aged 16 years or older who underwent a renal biopsy at Severance Hospital in the Yonsei University Health System from 1987 to 2006 were enrolled. All medical records were reviewed retrospectively.Results. In total, 1818 patients (M:F = 1.02:1) were reviewed. Glomerulonephritis (GN) comprised 85.9 of the total biopsied cases. The most common primary GN was IgA nephropathy (IgAN) (28.3), which was followed by minimal change disease (MCD) (15.5), membranous nephropathy (MN) (12.3), focal segmental glomerulosclerosis (FSGS) (5.6) and membranoproliferative GN (MPGN) (4.0). The most common secondary GN was lupus nephritis (8.7). The most common idiopathic nephrotic syndrome was MCD (38.5), which was followed by MN and IgAN. Among 128 (7.4) patients who were HBsAg-positive, MN (30.5) and MPGN (21.1) were the most common GN. When the incidence rates between 1987-91 and 2002-06 were compared, IgAN increased from 25.6 to 34.5, while MCD (from 23.2 to 7.0) and MPGN (from 6.7 to 1.7) decreased significantly (P < 0.01).Conclusions. IgAN was the most common primary GN, and MCD was the most common cause of nephrotic syndrome. In the 5-year quartile comparison, the relative frequency of IgAN increased, while the relative frequency of MCD and MPGN decreased significantly during the past 20 years.

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