Changing treatment patterns in elderly patients with resectable colon cancer

Gun Min Kim, Joong Bae Ahn, SunYoung Rha, Han Sang Kim, Beodeul Kang, Min Whan Kim, Soo Yeon Choi, Jae Kyung Roh, Hyuncheol Chung, Namkyu Kim, Sang Joon Shin

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Abstract

Aim: To evaluate changing treatment patterns and survival outcomes of elderly patients (age 70 years or older) with resectable colon cancer over the past 15 years. Methods: A total of 857 patients aged over 70 years who were managed for a resectable colon cancer between 1994 and 2010 were identified and their clinical variables were analyzed retrospectively. Results: The patients' median age was 74 years (range: 70-94 years). In all, 171 patients (20%) were stage I, 375 (43.8%) were stage II and 311 (36.3%) were stage III. Over 95% of all patients underwent surgery regardless of age or diagnosis year. In stage III colon cancer the proportion of patients who received adjuvant treatment increased the more recent the year of diagnosis (1994-2000, 47%; 2001-2005, 66%; 2006-2010, 70%; P=0.017). According to analysis by age group, older patients were less likely to receive adjuvant chemotherapy in both stage II (more than 75 years, 47.3%; 70-74 years, 59.4%; P<0.001) and stage III (more than 75 years, 51.1%; 70-74 years, 76.7%; P<0.001). Age-adjusted Charlson comorbidity index (CCI) is an independent prognostic factor for overall survival in stage II colon cancer patients. Conclusion: Elderly patients with resectable colon cancer received surgical treatment in more than 95% of cases without reference to age or diagnosis year. The proportion of patients who received adjuvant treatment increased according to the recency of diagnosis, but decreased abruptly according to increase in age.

Original languageEnglish
Pages (from-to)265-272
Number of pages8
JournalAsia-Pacific Journal of Clinical Oncology
Volume9
Issue number3
DOIs
Publication statusPublished - 2013 Sep 1

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Colonic Neoplasms
Therapeutics
Survival
Adjuvant Chemotherapy
Comorbidity
Age Groups

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Kim, Gun Min ; Ahn, Joong Bae ; Rha, SunYoung ; Kim, Han Sang ; Kang, Beodeul ; Kim, Min Whan ; Choi, Soo Yeon ; Roh, Jae Kyung ; Chung, Hyuncheol ; Kim, Namkyu ; Shin, Sang Joon. / Changing treatment patterns in elderly patients with resectable colon cancer. In: Asia-Pacific Journal of Clinical Oncology. 2013 ; Vol. 9, No. 3. pp. 265-272.
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title = "Changing treatment patterns in elderly patients with resectable colon cancer",
abstract = "Aim: To evaluate changing treatment patterns and survival outcomes of elderly patients (age 70 years or older) with resectable colon cancer over the past 15 years. Methods: A total of 857 patients aged over 70 years who were managed for a resectable colon cancer between 1994 and 2010 were identified and their clinical variables were analyzed retrospectively. Results: The patients' median age was 74 years (range: 70-94 years). In all, 171 patients (20{\%}) were stage I, 375 (43.8{\%}) were stage II and 311 (36.3{\%}) were stage III. Over 95{\%} of all patients underwent surgery regardless of age or diagnosis year. In stage III colon cancer the proportion of patients who received adjuvant treatment increased the more recent the year of diagnosis (1994-2000, 47{\%}; 2001-2005, 66{\%}; 2006-2010, 70{\%}; P=0.017). According to analysis by age group, older patients were less likely to receive adjuvant chemotherapy in both stage II (more than 75 years, 47.3{\%}; 70-74 years, 59.4{\%}; P<0.001) and stage III (more than 75 years, 51.1{\%}; 70-74 years, 76.7{\%}; P<0.001). Age-adjusted Charlson comorbidity index (CCI) is an independent prognostic factor for overall survival in stage II colon cancer patients. Conclusion: Elderly patients with resectable colon cancer received surgical treatment in more than 95{\%} of cases without reference to age or diagnosis year. The proportion of patients who received adjuvant treatment increased according to the recency of diagnosis, but decreased abruptly according to increase in age.",
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Changing treatment patterns in elderly patients with resectable colon cancer. / Kim, Gun Min; Ahn, Joong Bae; Rha, SunYoung; Kim, Han Sang; Kang, Beodeul; Kim, Min Whan; Choi, Soo Yeon; Roh, Jae Kyung; Chung, Hyuncheol; Kim, Namkyu; Shin, Sang Joon.

In: Asia-Pacific Journal of Clinical Oncology, Vol. 9, No. 3, 01.09.2013, p. 265-272.

Research output: Contribution to journalArticle

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AU - Ahn, Joong Bae

AU - Rha, SunYoung

AU - Kim, Han Sang

AU - Kang, Beodeul

AU - Kim, Min Whan

AU - Choi, Soo Yeon

AU - Roh, Jae Kyung

AU - Chung, Hyuncheol

AU - Kim, Namkyu

AU - Shin, Sang Joon

PY - 2013/9/1

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N2 - Aim: To evaluate changing treatment patterns and survival outcomes of elderly patients (age 70 years or older) with resectable colon cancer over the past 15 years. Methods: A total of 857 patients aged over 70 years who were managed for a resectable colon cancer between 1994 and 2010 were identified and their clinical variables were analyzed retrospectively. Results: The patients' median age was 74 years (range: 70-94 years). In all, 171 patients (20%) were stage I, 375 (43.8%) were stage II and 311 (36.3%) were stage III. Over 95% of all patients underwent surgery regardless of age or diagnosis year. In stage III colon cancer the proportion of patients who received adjuvant treatment increased the more recent the year of diagnosis (1994-2000, 47%; 2001-2005, 66%; 2006-2010, 70%; P=0.017). According to analysis by age group, older patients were less likely to receive adjuvant chemotherapy in both stage II (more than 75 years, 47.3%; 70-74 years, 59.4%; P<0.001) and stage III (more than 75 years, 51.1%; 70-74 years, 76.7%; P<0.001). Age-adjusted Charlson comorbidity index (CCI) is an independent prognostic factor for overall survival in stage II colon cancer patients. Conclusion: Elderly patients with resectable colon cancer received surgical treatment in more than 95% of cases without reference to age or diagnosis year. The proportion of patients who received adjuvant treatment increased according to the recency of diagnosis, but decreased abruptly according to increase in age.

AB - Aim: To evaluate changing treatment patterns and survival outcomes of elderly patients (age 70 years or older) with resectable colon cancer over the past 15 years. Methods: A total of 857 patients aged over 70 years who were managed for a resectable colon cancer between 1994 and 2010 were identified and their clinical variables were analyzed retrospectively. Results: The patients' median age was 74 years (range: 70-94 years). In all, 171 patients (20%) were stage I, 375 (43.8%) were stage II and 311 (36.3%) were stage III. Over 95% of all patients underwent surgery regardless of age or diagnosis year. In stage III colon cancer the proportion of patients who received adjuvant treatment increased the more recent the year of diagnosis (1994-2000, 47%; 2001-2005, 66%; 2006-2010, 70%; P=0.017). According to analysis by age group, older patients were less likely to receive adjuvant chemotherapy in both stage II (more than 75 years, 47.3%; 70-74 years, 59.4%; P<0.001) and stage III (more than 75 years, 51.1%; 70-74 years, 76.7%; P<0.001). Age-adjusted Charlson comorbidity index (CCI) is an independent prognostic factor for overall survival in stage II colon cancer patients. Conclusion: Elderly patients with resectable colon cancer received surgical treatment in more than 95% of cases without reference to age or diagnosis year. The proportion of patients who received adjuvant treatment increased according to the recency of diagnosis, but decreased abruptly according to increase in age.

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