Chaotic Activity with Low Frequency Vibration in Fibrillary Waves Predicts AF Recurrence after Cardioversion in Patients with Persistent Atrial Fibrillation

Junbeom Park, Hye Jin Hwang, Jaemin Shim, Sun Uhm, Boyoung Joung, huinam pak, Moon Hyoung Lee

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Background: We hypothesized that mathematical analysis of atrial fibrillary waves may predict recurrence of atrial fibrillation (AF) after cardioversion. Methods: We included 51 patients with symptomatic persistent AF (40 males, 57 ±8 years). All patients were assessed by holter and echocardiography within 3 months before cardioversion. We extracted only atrial fibrillary waves from V1 lead in holter and measured three parameters including approximate entropy (Aprx), Lyapunov-exponent (Lya) and center-frequency (Cent) to quantify entropy, chaotic activity and frequency, respectively. Recurrence was defined as AF episodes documented by EKG/holter within 30days after cardioversion. Results: The patients with recurrence (n=25) had higher Lya than those without recurrence (n=22)(0.258 ±0.157vs0.161 ±0.148, p=0.036), whereas Aprx was not related to recurrence (p>0.05). The patients with Lya>0.05 had more recurrence than those with Lya<0.05 (64%vs18%, p=0.008), and the patients with Cent<7.0 had more recurrence than those with high Cent>7.0 (68%vs35%, p=0.021). All patients were divided into three groups; groupA, the patients with high-Lya and low-Cent, groupB, those with high-Lya or low-Cent, groupC, those with low-Lya and high-Cent. GroupA showed more recurrence than groupB, and groupB did more recurrence than groupC. By logistic regression, Lya and Cent scale were strong independent predictors of recurrence (OR=6.9, CI:95% 2.0~23.5, p=0.002). Conclusions: Chaotic activity with low frequency in fibrillary waves could predict AF recurrence within 1month after cardioversion.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Issue number4
Publication statusPublished - 2011 Jan 1


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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