Chaperna: linking the ancient RNA and protein worlds

Ahyun Son, Scott Horowitz, Baik L. Seong

Research output: Contribution to journalReview article


As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with proteins of biological relevance. The ribozyme-resident protein folding activity, even before the advent of protein-based molecular chaperone, must have expedited the transition of the RNA world into the present protein theatre.

Original languageEnglish
JournalRNA Biology
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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