Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins

Sun Mi Park, Shimin Hu, Tae H. Lee, Xiaolu Yang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inhibitor of apoptosis (IAP) proteins are a family of evolutionarily conserved proteins that regulate apoptosis as well as other cellular processes. The functions of many IAPs are defined by their RING domains, which possess E3 ubiquitin ligase activity and promote proteasomal degradation of an increasing number of target proteins. In this chapter, we describe the methods used in our laboratories to study the IAP's E3 activity.

Original languageEnglish
Title of host publicationProgrammed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B
EditorsRoya Khosravi-Far, Zahra Zakeri, Richard Lockshin, Mauro Piacentini
Pages225-235
Number of pages11
DOIs
Publication statusPublished - 2008 Sep 24

Publication series

NameMethods in Enzymology
Volume446
ISSN (Print)0076-6879

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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    Park, S. M., Hu, S., Lee, T. H., & Yang, X. (2008). Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins. In R. Khosravi-Far, Z. Zakeri, R. Lockshin, & M. Piacentini (Eds.), Programmed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B (pp. 225-235). (Methods in Enzymology; Vol. 446). https://doi.org/10.1016/S0076-6879(08)01613-3