Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins

Sun Mi Park, Shimin Hu, Tae Ho Lee, Xiaolu Yang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inhibitor of apoptosis (IAP) proteins are a family of evolutionarily conserved proteins that regulate apoptosis as well as other cellular processes. The functions of many IAPs are defined by their RING domains, which possess E3 ubiquitin ligase activity and promote proteasomal degradation of an increasing number of target proteins. In this chapter, we describe the methods used in our laboratories to study the IAP's E3 activity.

Original languageEnglish
Title of host publicationProgrammed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B
EditorsRoya Khosravi-Far, Zahra Zakeri, Richard Lockshin, Mauro Piacentini
Pages225-235
Number of pages11
DOIs
Publication statusPublished - 2008 Sep 24

Publication series

NameMethods in Enzymology
Volume446
ISSN (Print)0076-6879

Fingerprint

Inhibitor of Apoptosis Proteins
Ubiquitination
Ubiquitin-Protein Ligases
Proteins
Apoptosis
Degradation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Park, S. M., Hu, S., Lee, T. H., & Yang, X. (2008). Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins. In R. Khosravi-Far, Z. Zakeri, R. Lockshin, & M. Piacentini (Eds.), Programmed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B (pp. 225-235). (Methods in Enzymology; Vol. 446). https://doi.org/10.1016/S0076-6879(08)01613-3
Park, Sun Mi ; Hu, Shimin ; Lee, Tae Ho ; Yang, Xiaolu. / Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins. Programmed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B. editor / Roya Khosravi-Far ; Zahra Zakeri ; Richard Lockshin ; Mauro Piacentini. 2008. pp. 225-235 (Methods in Enzymology).
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Park, SM, Hu, S, Lee, TH & Yang, X 2008, Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins. in R Khosravi-Far, Z Zakeri, R Lockshin & M Piacentini (eds), Programmed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B. Methods in Enzymology, vol. 446, pp. 225-235. https://doi.org/10.1016/S0076-6879(08)01613-3

Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins. / Park, Sun Mi; Hu, Shimin; Lee, Tae Ho; Yang, Xiaolu.

Programmed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B. ed. / Roya Khosravi-Far; Zahra Zakeri; Richard Lockshin; Mauro Piacentini. 2008. p. 225-235 (Methods in Enzymology; Vol. 446).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Park SM, Hu S, Lee TH, Yang X. Chapter 13 Ubiquitination Mediated by Inhibitor of Apoptosis Proteins. In Khosravi-Far R, Zakeri Z, Lockshin R, Piacentini M, editors, Programmed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B. 2008. p. 225-235. (Methods in Enzymology). https://doi.org/10.1016/S0076-6879(08)01613-3