Characteristic features of granular deposit formation in granular corneal dystrophy type 2

Sun Woong Kim, Samin Hong, Terry Kim, Kyu Seo Kim, Tae-im Kim, Woo Suk Chung, Eungkweon Kim

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Purpose: To describe the characteristic features of white granular deposits associated with granular corneal dystrophy type 2 (GCD2). Methods: Five patients with GCD2 associated with the R124H mutation (2 homozygous GCD2 and 3 heterozygotes) were examined. The corneal deposits of all patients were assessed and reviewed by slit-lamp photographs. Density line profiles of corneal surfaces were evaluated around the discrete corneal deposits using Image J software. A Fourier-domain optical coherence tomography with cornea anterior module was used to visualize the characteristic surrounding features of these granular deposits. A histopathological study of the homozygous corneal specimen obtained after keratoplasty was performed. Results: Slit-lamp images and densitometry line profiles showed that discrete granules were surrounded by relatively clear areas in all patients. The Fourier-domain optical coherence tomography image clearly showed highly reflective lesions, corresponding to the corneal deposits, surrounded by lower reflective areas. Histopathological study revealed comparable findings to the optical coherence tomography image. Serial comparison of slit-lamp photographs demonstrated a recurrence pattern after penetrating keratoplasty in a homozygous patient and natural progression in a heterozygote patient. They were similar in that diffuse fine granules gradually increased in density and discrete granular deposits also enlarged or were newly formed. Conclusions: In GCD2, discrete white granular deposits were surrounded by rather lucid areas and fine granular haze. These findings suggest that white granular deposits may be formed by aggregation of surrounding fine granules.

Original languageEnglish
Pages (from-to)848-854
Number of pages7
JournalCornea
Volume30
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1

Fingerprint

Optical Coherence Tomography
Heterozygote
Penetrating Keratoplasty
Corneal Transplantation
Densitometry
Cornea
Software
Corneal dystrophy Avellino type
Recurrence
Mutation
Slit Lamp

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Kim, Sun Woong ; Hong, Samin ; Kim, Terry ; Kim, Kyu Seo ; Kim, Tae-im ; Chung, Woo Suk ; Kim, Eungkweon. / Characteristic features of granular deposit formation in granular corneal dystrophy type 2. In: Cornea. 2011 ; Vol. 30, No. 8. pp. 848-854.
@article{5b473c7a4c6b419c9dc84821a6e51468,
title = "Characteristic features of granular deposit formation in granular corneal dystrophy type 2",
abstract = "Purpose: To describe the characteristic features of white granular deposits associated with granular corneal dystrophy type 2 (GCD2). Methods: Five patients with GCD2 associated with the R124H mutation (2 homozygous GCD2 and 3 heterozygotes) were examined. The corneal deposits of all patients were assessed and reviewed by slit-lamp photographs. Density line profiles of corneal surfaces were evaluated around the discrete corneal deposits using Image J software. A Fourier-domain optical coherence tomography with cornea anterior module was used to visualize the characteristic surrounding features of these granular deposits. A histopathological study of the homozygous corneal specimen obtained after keratoplasty was performed. Results: Slit-lamp images and densitometry line profiles showed that discrete granules were surrounded by relatively clear areas in all patients. The Fourier-domain optical coherence tomography image clearly showed highly reflective lesions, corresponding to the corneal deposits, surrounded by lower reflective areas. Histopathological study revealed comparable findings to the optical coherence tomography image. Serial comparison of slit-lamp photographs demonstrated a recurrence pattern after penetrating keratoplasty in a homozygous patient and natural progression in a heterozygote patient. They were similar in that diffuse fine granules gradually increased in density and discrete granular deposits also enlarged or were newly formed. Conclusions: In GCD2, discrete white granular deposits were surrounded by rather lucid areas and fine granular haze. These findings suggest that white granular deposits may be formed by aggregation of surrounding fine granules.",
author = "Kim, {Sun Woong} and Samin Hong and Terry Kim and Kim, {Kyu Seo} and Tae-im Kim and Chung, {Woo Suk} and Eungkweon Kim",
year = "2011",
month = "8",
day = "1",
doi = "10.1097/ICO.0b013e3182000c74",
language = "English",
volume = "30",
pages = "848--854",
journal = "Cornea",
issn = "0277-3740",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

Characteristic features of granular deposit formation in granular corneal dystrophy type 2. / Kim, Sun Woong; Hong, Samin; Kim, Terry; Kim, Kyu Seo; Kim, Tae-im; Chung, Woo Suk; Kim, Eungkweon.

In: Cornea, Vol. 30, No. 8, 01.08.2011, p. 848-854.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Characteristic features of granular deposit formation in granular corneal dystrophy type 2

AU - Kim, Sun Woong

AU - Hong, Samin

AU - Kim, Terry

AU - Kim, Kyu Seo

AU - Kim, Tae-im

AU - Chung, Woo Suk

AU - Kim, Eungkweon

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Purpose: To describe the characteristic features of white granular deposits associated with granular corneal dystrophy type 2 (GCD2). Methods: Five patients with GCD2 associated with the R124H mutation (2 homozygous GCD2 and 3 heterozygotes) were examined. The corneal deposits of all patients were assessed and reviewed by slit-lamp photographs. Density line profiles of corneal surfaces were evaluated around the discrete corneal deposits using Image J software. A Fourier-domain optical coherence tomography with cornea anterior module was used to visualize the characteristic surrounding features of these granular deposits. A histopathological study of the homozygous corneal specimen obtained after keratoplasty was performed. Results: Slit-lamp images and densitometry line profiles showed that discrete granules were surrounded by relatively clear areas in all patients. The Fourier-domain optical coherence tomography image clearly showed highly reflective lesions, corresponding to the corneal deposits, surrounded by lower reflective areas. Histopathological study revealed comparable findings to the optical coherence tomography image. Serial comparison of slit-lamp photographs demonstrated a recurrence pattern after penetrating keratoplasty in a homozygous patient and natural progression in a heterozygote patient. They were similar in that diffuse fine granules gradually increased in density and discrete granular deposits also enlarged or were newly formed. Conclusions: In GCD2, discrete white granular deposits were surrounded by rather lucid areas and fine granular haze. These findings suggest that white granular deposits may be formed by aggregation of surrounding fine granules.

AB - Purpose: To describe the characteristic features of white granular deposits associated with granular corneal dystrophy type 2 (GCD2). Methods: Five patients with GCD2 associated with the R124H mutation (2 homozygous GCD2 and 3 heterozygotes) were examined. The corneal deposits of all patients were assessed and reviewed by slit-lamp photographs. Density line profiles of corneal surfaces were evaluated around the discrete corneal deposits using Image J software. A Fourier-domain optical coherence tomography with cornea anterior module was used to visualize the characteristic surrounding features of these granular deposits. A histopathological study of the homozygous corneal specimen obtained after keratoplasty was performed. Results: Slit-lamp images and densitometry line profiles showed that discrete granules were surrounded by relatively clear areas in all patients. The Fourier-domain optical coherence tomography image clearly showed highly reflective lesions, corresponding to the corneal deposits, surrounded by lower reflective areas. Histopathological study revealed comparable findings to the optical coherence tomography image. Serial comparison of slit-lamp photographs demonstrated a recurrence pattern after penetrating keratoplasty in a homozygous patient and natural progression in a heterozygote patient. They were similar in that diffuse fine granules gradually increased in density and discrete granular deposits also enlarged or were newly formed. Conclusions: In GCD2, discrete white granular deposits were surrounded by rather lucid areas and fine granular haze. These findings suggest that white granular deposits may be formed by aggregation of surrounding fine granules.

UR - http://www.scopus.com/inward/record.url?scp=79960697187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960697187&partnerID=8YFLogxK

U2 - 10.1097/ICO.0b013e3182000c74

DO - 10.1097/ICO.0b013e3182000c74

M3 - Review article

VL - 30

SP - 848

EP - 854

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 8

ER -