Characteristic tissue interaction of the diastema region in mice

Hitoshi Yamamoto, Sung Won Cho, Soo Jin Song, Heui Jung Hwang, Min Jung Lee, Jae Young Kim, Hansung Jung

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Rodents have a toothless diastema between the incisor and the first molar, which may contain rudimentary tooth germs. In the lower diastema region of mice at E13, the rudimentary tooth germs, which developed into the bud stage before its removal by apoptosis, was found. The immunoreactivity to tenascin was observed in the condensed mesenchyme around the normal tooth bud and was detected in only the basement membrane in the diastema bud. This result shows that the relationship between mesenchymal condensation and tooth development. The similar patterns of Msx-1 and Msx-2 expression between the tooth bud and the diastema bud show that the diastema bud may have some other genetic mechanism in the developmental arrest of the rudimentary tooth germs rather than the Msx-1 and Msx-2 expression. Strikingly, the induction of the tooth formation was possible using tissue recombination between the oral epithelium of the diastema bud and the dental mesenchyme of the molar tooth bud, which indicates the potential capability of the diastema in the tooth formation. In conclusion, it is suggested that the condensed mesenchyme may be the key to tooth development.

Original languageEnglish
Pages (from-to)189-198
Number of pages10
JournalArchives of Oral Biology
Volume50
Issue number2 SPEC. ISS.
DOIs
Publication statusPublished - 2005 Jan 1

Fingerprint

Diastema
Tooth
Tooth Germ
Mesoderm
Tenascin
Incisor
Basement Membrane
Genetic Recombination
Rodentia
Epithelium
Apoptosis

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

Yamamoto, H., Cho, S. W., Song, S. J., Hwang, H. J., Lee, M. J., Kim, J. Y., & Jung, H. (2005). Characteristic tissue interaction of the diastema region in mice. Archives of Oral Biology, 50(2 SPEC. ISS.), 189-198. https://doi.org/10.1016/j.archoralbio.2004.11.010
Yamamoto, Hitoshi ; Cho, Sung Won ; Song, Soo Jin ; Hwang, Heui Jung ; Lee, Min Jung ; Kim, Jae Young ; Jung, Hansung. / Characteristic tissue interaction of the diastema region in mice. In: Archives of Oral Biology. 2005 ; Vol. 50, No. 2 SPEC. ISS. pp. 189-198.
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Yamamoto, H, Cho, SW, Song, SJ, Hwang, HJ, Lee, MJ, Kim, JY & Jung, H 2005, 'Characteristic tissue interaction of the diastema region in mice', Archives of Oral Biology, vol. 50, no. 2 SPEC. ISS., pp. 189-198. https://doi.org/10.1016/j.archoralbio.2004.11.010

Characteristic tissue interaction of the diastema region in mice. / Yamamoto, Hitoshi; Cho, Sung Won; Song, Soo Jin; Hwang, Heui Jung; Lee, Min Jung; Kim, Jae Young; Jung, Hansung.

In: Archives of Oral Biology, Vol. 50, No. 2 SPEC. ISS., 01.01.2005, p. 189-198.

Research output: Contribution to journalArticle

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Yamamoto H, Cho SW, Song SJ, Hwang HJ, Lee MJ, Kim JY et al. Characteristic tissue interaction of the diastema region in mice. Archives of Oral Biology. 2005 Jan 1;50(2 SPEC. ISS.):189-198. https://doi.org/10.1016/j.archoralbio.2004.11.010