Optimal treatments for multiple myeloma (MM) patients with high-risk cytogenetics must be determined, but subgroup features are not well-defined. We used real-world data from the Korean Myeloma Registry (KMR) to analyze the characteristics and clinical outcomes of newly diagnosed MM patients with ≥ 1 high-risk cytogenetic abnormality: Group 1: t(4;14) or t(14;16); Group 2: del(17p); Group 3: t(4;14)/del(17p) or t(14;16)/del(17p). Overall, 347 high-risk patients were identified (males, 48.7%; median age, 63 years). Median progression-free survival (PFS) and overall survival (OS) were 19.0 months (95% CI 17.0–20.0) and 50.0 months (95% CI 37.0–61.0), respectively. PFS (p = 0.047) and OS (p = 0.020) differed significantly between groups. After stratification by transplant eligibility, PFS and OS were significantly poorer in Group 3 among transplant-eligible patients, and even poorer in those with gain(1q). Patients stratified by cytogenetic abnormality and revised International Staging System (R-ISS) had significantly different PFS (p < 0.001) and OS (p = 0.003), with the worst survival in R-ISS III/Group 3 (median OS 21.0 months). Higher number of high-risk cytogenetic abnormalities was a negative prognostic marker for PFS and OS (p < 0.001). Real-world KMR data showed that risk factors for poor prognosis of MM patients included del(17p), R-ISS stage, and number of cytogenetic abnormalities.
|Number of pages||12|
|Journal||International Journal of Hematology|
|Publication status||Published - 2022 Jul|
Bibliographical noteFunding Information:
Under the direction of the authors, medical writing assistance was provided by Robert A. Furlong PhD and David P. Figgitt PhD, ISMPP CMPP™, Content Ed Net, with funding from Amgen Korea.
This study was funded by Amgen Korea.
Kihyun Kim, Jin Seok Kim, Sung-Soo Yoon, Dok Hyun Yoon, Hyeon-Seok Eom, Je-Jung Lee, Hyeon Woo Yim, Misun Park and Chang-Ki Min report consultancy and research funding from Amgen Korea. Hojoon Lee reports employment by Amgen Korea.
© 2022, Japanese Society of Hematology.
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