Characteristics and survival of breast cancer patients with multiple synchronous or metachronous primary cancers

Janghee Lee, Seho Park, Sanghwa Kim, Jeeye Kim, Jegyu Ryu, Hyung Seok Park, Seung Il Kim, Byeongwoo Park

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: Newly developed extra-mammary multiple primary cancers (MPCs) are an issue of concern when considering the management of breast cancer survivors. This study aimed to investigate the prevalence of MPCs and to evaluate the implications of MPCs on the survival of breast cancer patients. Materials and Methods: A total of 8204 patients who underwent surgery at Severance Hospital between 1990 and 2012 were retrospectively selected. Clinicopathologic features and survival over follow-up periods of ≤5 and >5 years were investigated using univariate and multivariate analyses. Results: During a mean follow-up of 67.3 months, 962 MPCs in 858 patients (10.5%) were detected. Synchronous and metachronous MPCs were identified in 23.8% and 79.0% of patients, respectively. Thyroid cancer was the most prevalent, and the second most common was gynecologic cancer. At ≤5 years, patients with MPCs were older and demonstrated significantly worse survival despite a higher proportion of patients with lower-stage MPCs. Nevertheless, an increased risk of death in patients with MPCs did not reach statistical significance at >5 years. The causes of death in many of the patients with MPCs were not related to breast cancer. Stage-matched analysis revealed that the implications of MPCs on survival were more evident in the early stages of breast disease. Conclusion: Breast cancer patients with MPCs showed worse survival, especially when early-stage disease was identified. Therefore, it is necessary to follow screening programs in breast cancer survivors and to establish guidelines for improving prognosis and quality of life.

Original languageEnglish
Pages (from-to)1213-1220
Number of pages8
JournalYonsei medical journal
Volume56
Issue number5
DOIs
Publication statusPublished - 2015 Sep 1

Fingerprint

Breast Neoplasms
Survival
Neoplasms
Survivors
Breast Diseases
Thyroid Neoplasms
Cause of Death
Breast
Multivariate Analysis
Quality of Life
Guidelines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Janghee ; Park, Seho ; Kim, Sanghwa ; Kim, Jeeye ; Ryu, Jegyu ; Park, Hyung Seok ; Kim, Seung Il ; Park, Byeongwoo. / Characteristics and survival of breast cancer patients with multiple synchronous or metachronous primary cancers. In: Yonsei medical journal. 2015 ; Vol. 56, No. 5. pp. 1213-1220.
@article{f289de1a2d054048b8deb7a16c25b355,
title = "Characteristics and survival of breast cancer patients with multiple synchronous or metachronous primary cancers",
abstract = "Purpose: Newly developed extra-mammary multiple primary cancers (MPCs) are an issue of concern when considering the management of breast cancer survivors. This study aimed to investigate the prevalence of MPCs and to evaluate the implications of MPCs on the survival of breast cancer patients. Materials and Methods: A total of 8204 patients who underwent surgery at Severance Hospital between 1990 and 2012 were retrospectively selected. Clinicopathologic features and survival over follow-up periods of ≤5 and >5 years were investigated using univariate and multivariate analyses. Results: During a mean follow-up of 67.3 months, 962 MPCs in 858 patients (10.5{\%}) were detected. Synchronous and metachronous MPCs were identified in 23.8{\%} and 79.0{\%} of patients, respectively. Thyroid cancer was the most prevalent, and the second most common was gynecologic cancer. At ≤5 years, patients with MPCs were older and demonstrated significantly worse survival despite a higher proportion of patients with lower-stage MPCs. Nevertheless, an increased risk of death in patients with MPCs did not reach statistical significance at >5 years. The causes of death in many of the patients with MPCs were not related to breast cancer. Stage-matched analysis revealed that the implications of MPCs on survival were more evident in the early stages of breast disease. Conclusion: Breast cancer patients with MPCs showed worse survival, especially when early-stage disease was identified. Therefore, it is necessary to follow screening programs in breast cancer survivors and to establish guidelines for improving prognosis and quality of life.",
author = "Janghee Lee and Seho Park and Sanghwa Kim and Jeeye Kim and Jegyu Ryu and Park, {Hyung Seok} and Kim, {Seung Il} and Byeongwoo Park",
year = "2015",
month = "9",
day = "1",
doi = "10.3349/ymj.2015.56.5.1213",
language = "English",
volume = "56",
pages = "1213--1220",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "5",

}

Characteristics and survival of breast cancer patients with multiple synchronous or metachronous primary cancers. / Lee, Janghee; Park, Seho; Kim, Sanghwa; Kim, Jeeye; Ryu, Jegyu; Park, Hyung Seok; Kim, Seung Il; Park, Byeongwoo.

In: Yonsei medical journal, Vol. 56, No. 5, 01.09.2015, p. 1213-1220.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characteristics and survival of breast cancer patients with multiple synchronous or metachronous primary cancers

AU - Lee, Janghee

AU - Park, Seho

AU - Kim, Sanghwa

AU - Kim, Jeeye

AU - Ryu, Jegyu

AU - Park, Hyung Seok

AU - Kim, Seung Il

AU - Park, Byeongwoo

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Purpose: Newly developed extra-mammary multiple primary cancers (MPCs) are an issue of concern when considering the management of breast cancer survivors. This study aimed to investigate the prevalence of MPCs and to evaluate the implications of MPCs on the survival of breast cancer patients. Materials and Methods: A total of 8204 patients who underwent surgery at Severance Hospital between 1990 and 2012 were retrospectively selected. Clinicopathologic features and survival over follow-up periods of ≤5 and >5 years were investigated using univariate and multivariate analyses. Results: During a mean follow-up of 67.3 months, 962 MPCs in 858 patients (10.5%) were detected. Synchronous and metachronous MPCs were identified in 23.8% and 79.0% of patients, respectively. Thyroid cancer was the most prevalent, and the second most common was gynecologic cancer. At ≤5 years, patients with MPCs were older and demonstrated significantly worse survival despite a higher proportion of patients with lower-stage MPCs. Nevertheless, an increased risk of death in patients with MPCs did not reach statistical significance at >5 years. The causes of death in many of the patients with MPCs were not related to breast cancer. Stage-matched analysis revealed that the implications of MPCs on survival were more evident in the early stages of breast disease. Conclusion: Breast cancer patients with MPCs showed worse survival, especially when early-stage disease was identified. Therefore, it is necessary to follow screening programs in breast cancer survivors and to establish guidelines for improving prognosis and quality of life.

AB - Purpose: Newly developed extra-mammary multiple primary cancers (MPCs) are an issue of concern when considering the management of breast cancer survivors. This study aimed to investigate the prevalence of MPCs and to evaluate the implications of MPCs on the survival of breast cancer patients. Materials and Methods: A total of 8204 patients who underwent surgery at Severance Hospital between 1990 and 2012 were retrospectively selected. Clinicopathologic features and survival over follow-up periods of ≤5 and >5 years were investigated using univariate and multivariate analyses. Results: During a mean follow-up of 67.3 months, 962 MPCs in 858 patients (10.5%) were detected. Synchronous and metachronous MPCs were identified in 23.8% and 79.0% of patients, respectively. Thyroid cancer was the most prevalent, and the second most common was gynecologic cancer. At ≤5 years, patients with MPCs were older and demonstrated significantly worse survival despite a higher proportion of patients with lower-stage MPCs. Nevertheless, an increased risk of death in patients with MPCs did not reach statistical significance at >5 years. The causes of death in many of the patients with MPCs were not related to breast cancer. Stage-matched analysis revealed that the implications of MPCs on survival were more evident in the early stages of breast disease. Conclusion: Breast cancer patients with MPCs showed worse survival, especially when early-stage disease was identified. Therefore, it is necessary to follow screening programs in breast cancer survivors and to establish guidelines for improving prognosis and quality of life.

UR - http://www.scopus.com/inward/record.url?scp=84938849278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938849278&partnerID=8YFLogxK

U2 - 10.3349/ymj.2015.56.5.1213

DO - 10.3349/ymj.2015.56.5.1213

M3 - Article

VL - 56

SP - 1213

EP - 1220

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 5

ER -