Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-β-lactamases

Kyungwon Lee, Chang Ki Kim, Seong Geun Hong, Jonghyeon Choi, Sungwook Song, Eunmi Koh, DongEun Yong, Seokhoon Jeong, Jong Hwa Yum, Jean Denis Docquier, Gian Maria Rossolini, Yunsop Chong

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Acquired metallo-β-lactamase (MBL) production is an important mechanism of carbapenem resistance. To our knowledge, carriage of two different MBLs has not been described previously in Acinetobacter spp. We present the characteristics of five Acinetobacter isolates carrying two different MBL genes. The species of all five Acinetobacter isolates with two different MBL genes were Acinetobacter genomospecies 10, and bla IMP-1 , bla VIM-2 and bla SIM-1 may coexist in this species. Minimum inhibitory concentrations (MICs) of imipenem for all five isolates with two different MBLs were ≥32μg/mL, whilst those for two segregants that lost both MBLs were 0.5μg/mL. The presence of MBL gene-carrying integrons with identical structures suggested the easily transferable nature of the elements, whilst instability of the MBL genes indicated potentially erroneous phenotypic and genetic characterisation.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume36
Issue number3
DOIs
Publication statusPublished - 2010 Sep 1

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Acinetobacter
Genes
Integrons
Inosine Monophosphate
Carbapenems
Imipenem
Microbial Sensitivity Tests

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Lee, Kyungwon ; Kim, Chang Ki ; Hong, Seong Geun ; Choi, Jonghyeon ; Song, Sungwook ; Koh, Eunmi ; Yong, DongEun ; Jeong, Seokhoon ; Yum, Jong Hwa ; Docquier, Jean Denis ; Rossolini, Gian Maria ; Chong, Yunsop. / Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-β-lactamases. In: International Journal of Antimicrobial Agents. 2010 ; Vol. 36, No. 3. pp. 259-263.
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Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-β-lactamases. / Lee, Kyungwon; Kim, Chang Ki; Hong, Seong Geun; Choi, Jonghyeon; Song, Sungwook; Koh, Eunmi; Yong, DongEun; Jeong, Seokhoon; Yum, Jong Hwa; Docquier, Jean Denis; Rossolini, Gian Maria; Chong, Yunsop.

In: International Journal of Antimicrobial Agents, Vol. 36, No. 3, 01.09.2010, p. 259-263.

Research output: Contribution to journalArticle

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