Characteristics of ethylnitrosourea-induced cataracts

Min Jung Lee, Jae Young Kim, Yeun Jung Kim, Jae Woo Cho, Kyu Hyuk Cho, Chang Woo Song, Han Sung Jung

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: This study analyzed genes associated with the morphology and regulation of ethylnitrosourea (ENU)-induced cataract mouse. Materials and Methods: Immunohistochemistry analysis using anti-crystallins and PCNA antibody revealed that the localization pattern of these specific markers differed between the cataractous and wild-type lens epithelium. Two-dimensional electrophoresis and microarray techniques were used to identify the proteins and genes related to ENU-induced cataract. Results: A novel ENU-induced mutation in the mouse led to nuclear and cortical opacity of the eye lens at 5 weeks postnatal. This cataract phenotype was similar to that of the zonular-pulverulent type of human cataract. Crystallin proteins and gap-junction genes have relations to the formation of cataract. Conclusions: Together, the results suggest that various proteins affect the formation and specific phenotypes of ENU-induced cataract mouse.

Original languageEnglish
Pages (from-to)360-368
Number of pages9
JournalCurrent Eye Research
Issue number5
Publication statusPublished - 2009 May

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MEST) (No. R13-2003-013-05001-0).

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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