Characteristics of korean patients with primary adrenal insufficiency: A registry-based nationwide survey in Korea

The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Primary adrenal insufficiency (PAI) is a rare, potentially life-threatening condition. There are few Korean studies on PAI, and most have had small sample sizes. We aimed to examine the etiology, clinical characteristics, treatment, and mortality of PAI in Korean patients. Methods: A nationwide, multicenter, registry-based survey was conducted to identify adults diagnosed with or treated for PAI at 30 secondary or tertiary care institutions in Korea between 2000 and 2014. Results: A total of 269 patients with PAI were identified. The prevalence of PAI was 4.17 per million. The estimated incidence was 0.45 per million per year. The mean age at diagnosis was 49.0 years, and PAI was more prevalent in men. Adrenal tuberculosis was the most common cause of PAI in patients diagnosed before 2000; for those diagnosed thereafter, adrenal metastasis and tuberculosis were comparable leading causes. The etiology of PAI was not identified in 34.9% of cases. Of the patients receiving glucocorticoid replacement therapy, prednisolone was more frequently administered than hydrocortisone (69.4% vs. 26.5%, respectively), and only 27.1% of all patients received fludrocortisone. We observed an increased prevalence of metabolic disease and osteoporosis during the follow-up period (median, 60.2 months). The observed overall mortality and disease-specific mortality rates were 11.9% and 3.1%, respectively. Conclusion: The prevalence of PAI is significantly lower in Koreans than in reports from Western countries. The high frequency undetermined etiology in patients with PAI suggests the need to reveal accurate etiology of PAI in Korea.

Original languageEnglish
Pages (from-to)466-474
Number of pages9
JournalEndocrinology and Metabolism
Volume32
Issue number4
DOIs
Publication statusPublished - 2017 Dec 1

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Addison Disease
Korea
Registries
Mortality
Surveys and Questionnaires
Tuberculosis
Fludrocortisone
Secondary Care
Metabolic Diseases
Tertiary Healthcare
Prednisolone
Sample Size
Glucocorticoids
Osteoporosis
Hydrocortisone

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society. / Characteristics of korean patients with primary adrenal insufficiency : A registry-based nationwide survey in Korea. In: Endocrinology and Metabolism. 2017 ; Vol. 32, No. 4. pp. 466-474.
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title = "Characteristics of korean patients with primary adrenal insufficiency: A registry-based nationwide survey in Korea",
abstract = "Background: Primary adrenal insufficiency (PAI) is a rare, potentially life-threatening condition. There are few Korean studies on PAI, and most have had small sample sizes. We aimed to examine the etiology, clinical characteristics, treatment, and mortality of PAI in Korean patients. Methods: A nationwide, multicenter, registry-based survey was conducted to identify adults diagnosed with or treated for PAI at 30 secondary or tertiary care institutions in Korea between 2000 and 2014. Results: A total of 269 patients with PAI were identified. The prevalence of PAI was 4.17 per million. The estimated incidence was 0.45 per million per year. The mean age at diagnosis was 49.0 years, and PAI was more prevalent in men. Adrenal tuberculosis was the most common cause of PAI in patients diagnosed before 2000; for those diagnosed thereafter, adrenal metastasis and tuberculosis were comparable leading causes. The etiology of PAI was not identified in 34.9{\%} of cases. Of the patients receiving glucocorticoid replacement therapy, prednisolone was more frequently administered than hydrocortisone (69.4{\%} vs. 26.5{\%}, respectively), and only 27.1{\%} of all patients received fludrocortisone. We observed an increased prevalence of metabolic disease and osteoporosis during the follow-up period (median, 60.2 months). The observed overall mortality and disease-specific mortality rates were 11.9{\%} and 3.1{\%}, respectively. Conclusion: The prevalence of PAI is significantly lower in Koreans than in reports from Western countries. The high frequency undetermined etiology in patients with PAI suggests the need to reveal accurate etiology of PAI in Korea.",
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The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society 2017, 'Characteristics of korean patients with primary adrenal insufficiency: A registry-based nationwide survey in Korea', Endocrinology and Metabolism, vol. 32, no. 4, pp. 466-474. https://doi.org/10.3803/EnM.2017.32.4.466

Characteristics of korean patients with primary adrenal insufficiency : A registry-based nationwide survey in Korea. / The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society.

In: Endocrinology and Metabolism, Vol. 32, No. 4, 01.12.2017, p. 466-474.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characteristics of korean patients with primary adrenal insufficiency

T2 - A registry-based nationwide survey in Korea

AU - The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society

AU - Hong, A. Ram

AU - Ryu, Ohk Hyun

AU - Kim, Seong Yeon

AU - Kim, Sang Wan

AU - Cho, Eun Hee

AU - Choi, Dong Seop

AU - Chung, Choon Hee

AU - Chung, Dong Jin

AU - Chung, Ho Yeon

AU - Kang, Ho Cheol

AU - Kang, Mi Yeon

AU - Kim, Chul Hee

AU - Kim, Doo Man

AU - Kim, Hye Sun

AU - Kim, In Joo

AU - Kim, Jae Hyeon

AU - Kim, Jin Taek

AU - Kim, Jung Guk

AU - Kim, Jung Hee Kim

AU - Kim, Kyoung Min

AU - Kim, Kyung Ah

AU - Ko, Seung Hyun

AU - Lee, Sang Ah

AU - Lee, Seung Hun

AU - Lim, Dong Mee

AU - Moon, Sung Dae

AU - Park, Jong Suk

AU - Rhee, Sang Youl

AU - Rhee, Yumie

AU - Song, Kee Ho

AU - Song, Min Ho

AU - Yu, Sung Hoon

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background: Primary adrenal insufficiency (PAI) is a rare, potentially life-threatening condition. There are few Korean studies on PAI, and most have had small sample sizes. We aimed to examine the etiology, clinical characteristics, treatment, and mortality of PAI in Korean patients. Methods: A nationwide, multicenter, registry-based survey was conducted to identify adults diagnosed with or treated for PAI at 30 secondary or tertiary care institutions in Korea between 2000 and 2014. Results: A total of 269 patients with PAI were identified. The prevalence of PAI was 4.17 per million. The estimated incidence was 0.45 per million per year. The mean age at diagnosis was 49.0 years, and PAI was more prevalent in men. Adrenal tuberculosis was the most common cause of PAI in patients diagnosed before 2000; for those diagnosed thereafter, adrenal metastasis and tuberculosis were comparable leading causes. The etiology of PAI was not identified in 34.9% of cases. Of the patients receiving glucocorticoid replacement therapy, prednisolone was more frequently administered than hydrocortisone (69.4% vs. 26.5%, respectively), and only 27.1% of all patients received fludrocortisone. We observed an increased prevalence of metabolic disease and osteoporosis during the follow-up period (median, 60.2 months). The observed overall mortality and disease-specific mortality rates were 11.9% and 3.1%, respectively. Conclusion: The prevalence of PAI is significantly lower in Koreans than in reports from Western countries. The high frequency undetermined etiology in patients with PAI suggests the need to reveal accurate etiology of PAI in Korea.

AB - Background: Primary adrenal insufficiency (PAI) is a rare, potentially life-threatening condition. There are few Korean studies on PAI, and most have had small sample sizes. We aimed to examine the etiology, clinical characteristics, treatment, and mortality of PAI in Korean patients. Methods: A nationwide, multicenter, registry-based survey was conducted to identify adults diagnosed with or treated for PAI at 30 secondary or tertiary care institutions in Korea between 2000 and 2014. Results: A total of 269 patients with PAI were identified. The prevalence of PAI was 4.17 per million. The estimated incidence was 0.45 per million per year. The mean age at diagnosis was 49.0 years, and PAI was more prevalent in men. Adrenal tuberculosis was the most common cause of PAI in patients diagnosed before 2000; for those diagnosed thereafter, adrenal metastasis and tuberculosis were comparable leading causes. The etiology of PAI was not identified in 34.9% of cases. Of the patients receiving glucocorticoid replacement therapy, prednisolone was more frequently administered than hydrocortisone (69.4% vs. 26.5%, respectively), and only 27.1% of all patients received fludrocortisone. We observed an increased prevalence of metabolic disease and osteoporosis during the follow-up period (median, 60.2 months). The observed overall mortality and disease-specific mortality rates were 11.9% and 3.1%, respectively. Conclusion: The prevalence of PAI is significantly lower in Koreans than in reports from Western countries. The high frequency undetermined etiology in patients with PAI suggests the need to reveal accurate etiology of PAI in Korea.

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U2 - 10.3803/EnM.2017.32.4.466

DO - 10.3803/EnM.2017.32.4.466

M3 - Article

AN - SCOPUS:85038847055

VL - 32

SP - 466

EP - 474

JO - Endocrinology and Metabolism

JF - Endocrinology and Metabolism

SN - 2093-596X

IS - 4

ER -