Characteristics of local delivery agents for treating peri-implantitis on dental implant surfaces: A preclinical study

Jong Bin Lee, Helen Hye In Kweon, Hyun Jae Cho, Chang Sung Kim, Young Taek Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Local delivery agents (LDAs) are widely used in peri-implantitis treatments. The aim of this study was to identify LDAs remaining on the dental implant surfaces and to analyze the components of these residues after applying various cleaning methods. Implants were prepared with a sand-blasted, large-grit, acid-etched surface. Four kinds of LDAs were applied on the implant surfaces: chlorhexidine gel (group 2), tetracycline solution (group 3), and 2 kinds of minocycline hydrochloride agents (groups 4 and 5). Group 1 received normal saline as a control. Two cleaning methods were applied for different durations as follows: (1) running distilled water for 10 seconds (subgroup A), 5 minutes (subgroup B), and 15 minutes (subgroup C); and (2) water spray of a dental-unit chair for 10 seconds (subgroup D) and 5 minutes (subgroup E). Scanning electron microscopy and energy-dispersive x-ray spectroscopy were used to analyze the surface morphology and residue components for all implants. The amount of LDA removed from the implant surfaces in groups 1, 2, 3, and 5 increased with the cleaning duration and pressure. However, Minocline remained coated on the implant surfaces in group 4 under all cleaning conditions. Minocline could not be cleaned off well by water due to its hydrophobicity. Therefore, directly using this agent on implant surfaces with peri-implantitis should be carefully considered. The presence of LDA residues without drug efficacies on implant surfaces might interfere with reosseointegration and act as a reservoir of microorganisms.

Original languageEnglish
Pages (from-to)116-126
Number of pages11
JournalJournal of Oral Implantology
Volume45
Issue number2
DOIs
Publication statusPublished - 2019 Apr

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Peri-Implantitis
Dental Implants
Water
Drug Residues
Minocycline
Chlorhexidine
Tetracycline
Hydrophobic and Hydrophilic Interactions
Electron Scanning Microscopy
Spectrum Analysis
Tooth
Gels
X-Rays
Pressure
Acids

All Science Journal Classification (ASJC) codes

  • Oral Surgery

Cite this

Lee, Jong Bin ; Kweon, Helen Hye In ; Cho, Hyun Jae ; Kim, Chang Sung ; Kim, Young Taek. / Characteristics of local delivery agents for treating peri-implantitis on dental implant surfaces : A preclinical study. In: Journal of Oral Implantology. 2019 ; Vol. 45, No. 2. pp. 116-126.
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Characteristics of local delivery agents for treating peri-implantitis on dental implant surfaces : A preclinical study. / Lee, Jong Bin; Kweon, Helen Hye In; Cho, Hyun Jae; Kim, Chang Sung; Kim, Young Taek.

In: Journal of Oral Implantology, Vol. 45, No. 2, 04.2019, p. 116-126.

Research output: Contribution to journalArticle

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