Characteristics of resting-state functional connectivity in HIV-associated neurocognitive disorder

Hea Won Ann, Suhnyoung Jun, Na Young Shin, Sanghoon Han, Jin Young Ahn, Mi Young Ahn, Yong Duk Jeon, In Young Jung, Moo Hyun Kim, Woo Yong Jeong, Nam Su Ku, June Myung Kim, Davey M. Smith, JunYong Choi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding of HAND. Methods We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 11 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied. Results Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function and 1 was excluded for worsening liver disease. Among the 12 patients who previously had normal neurocognitive function, 2 showed neurocognitive impairment. Overall, the HAND group, who had impaired cognitive function at the time of MRI scan, showed significant decrease of resting status functional connectivity between bilateral precuneus and prefrontal cortex (PFC) compared with nonHAND group, those who had normal neurocognitive function (Corrected P<0.05). The functional connectivity with the right inferior frontal operculum and right superior frontal gyrus was positively correlated with memory and learning ability. Conclusions This cross-sectional study found a significant difference in fMRI patterns between patients with and without HAND. Decreased functional connectivity between precuneus and PFC could be possible functional substrate for cognitive dysfunction in HIV patients, which should be characterized in a longitudinal study.

Original languageEnglish
Article numbere0153493
JournalPloS one
Volume11
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

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HIV
Seed
Brain
Parietal Lobe
Magnetic Resonance Imaging
Prefrontal Cortex
functional status
brain
Liver
liver diseases
longitudinal studies
seeds
cognition
cross-sectional studies
Seeds
cortex
Data storage equipment
learning
Neurocognitive Disorders
Testing

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ann, Hea Won ; Jun, Suhnyoung ; Shin, Na Young ; Han, Sanghoon ; Ahn, Jin Young ; Ahn, Mi Young ; Jeon, Yong Duk ; Jung, In Young ; Kim, Moo Hyun ; Jeong, Woo Yong ; Ku, Nam Su ; Kim, June Myung ; Smith, Davey M. ; Choi, JunYong. / Characteristics of resting-state functional connectivity in HIV-associated neurocognitive disorder. In: PloS one. 2016 ; Vol. 11, No. 4.
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title = "Characteristics of resting-state functional connectivity in HIV-associated neurocognitive disorder",
abstract = "Background HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding of HAND. Methods We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 11 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied. Results Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function and 1 was excluded for worsening liver disease. Among the 12 patients who previously had normal neurocognitive function, 2 showed neurocognitive impairment. Overall, the HAND group, who had impaired cognitive function at the time of MRI scan, showed significant decrease of resting status functional connectivity between bilateral precuneus and prefrontal cortex (PFC) compared with nonHAND group, those who had normal neurocognitive function (Corrected P<0.05). The functional connectivity with the right inferior frontal operculum and right superior frontal gyrus was positively correlated with memory and learning ability. Conclusions This cross-sectional study found a significant difference in fMRI patterns between patients with and without HAND. Decreased functional connectivity between precuneus and PFC could be possible functional substrate for cognitive dysfunction in HIV patients, which should be characterized in a longitudinal study.",
author = "Ann, {Hea Won} and Suhnyoung Jun and Shin, {Na Young} and Sanghoon Han and Ahn, {Jin Young} and Ahn, {Mi Young} and Jeon, {Yong Duk} and Jung, {In Young} and Kim, {Moo Hyun} and Jeong, {Woo Yong} and Ku, {Nam Su} and Kim, {June Myung} and Smith, {Davey M.} and JunYong Choi",
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Ann, HW, Jun, S, Shin, NY, Han, S, Ahn, JY, Ahn, MY, Jeon, YD, Jung, IY, Kim, MH, Jeong, WY, Ku, NS, Kim, JM, Smith, DM & Choi, J 2016, 'Characteristics of resting-state functional connectivity in HIV-associated neurocognitive disorder', PloS one, vol. 11, no. 4, e0153493. https://doi.org/10.1371/journal.pone.0153493

Characteristics of resting-state functional connectivity in HIV-associated neurocognitive disorder. / Ann, Hea Won; Jun, Suhnyoung; Shin, Na Young; Han, Sanghoon; Ahn, Jin Young; Ahn, Mi Young; Jeon, Yong Duk; Jung, In Young; Kim, Moo Hyun; Jeong, Woo Yong; Ku, Nam Su; Kim, June Myung; Smith, Davey M.; Choi, JunYong.

In: PloS one, Vol. 11, No. 4, e0153493, 01.04.2016.

Research output: Contribution to journalArticle

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T1 - Characteristics of resting-state functional connectivity in HIV-associated neurocognitive disorder

AU - Ann, Hea Won

AU - Jun, Suhnyoung

AU - Shin, Na Young

AU - Han, Sanghoon

AU - Ahn, Jin Young

AU - Ahn, Mi Young

AU - Jeon, Yong Duk

AU - Jung, In Young

AU - Kim, Moo Hyun

AU - Jeong, Woo Yong

AU - Ku, Nam Su

AU - Kim, June Myung

AU - Smith, Davey M.

AU - Choi, JunYong

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding of HAND. Methods We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 11 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied. Results Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function and 1 was excluded for worsening liver disease. Among the 12 patients who previously had normal neurocognitive function, 2 showed neurocognitive impairment. Overall, the HAND group, who had impaired cognitive function at the time of MRI scan, showed significant decrease of resting status functional connectivity between bilateral precuneus and prefrontal cortex (PFC) compared with nonHAND group, those who had normal neurocognitive function (Corrected P<0.05). The functional connectivity with the right inferior frontal operculum and right superior frontal gyrus was positively correlated with memory and learning ability. Conclusions This cross-sectional study found a significant difference in fMRI patterns between patients with and without HAND. Decreased functional connectivity between precuneus and PFC could be possible functional substrate for cognitive dysfunction in HIV patients, which should be characterized in a longitudinal study.

AB - Background HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding of HAND. Methods We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 11 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied. Results Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function and 1 was excluded for worsening liver disease. Among the 12 patients who previously had normal neurocognitive function, 2 showed neurocognitive impairment. Overall, the HAND group, who had impaired cognitive function at the time of MRI scan, showed significant decrease of resting status functional connectivity between bilateral precuneus and prefrontal cortex (PFC) compared with nonHAND group, those who had normal neurocognitive function (Corrected P<0.05). The functional connectivity with the right inferior frontal operculum and right superior frontal gyrus was positively correlated with memory and learning ability. Conclusions This cross-sectional study found a significant difference in fMRI patterns between patients with and without HAND. Decreased functional connectivity between precuneus and PFC could be possible functional substrate for cognitive dysfunction in HIV patients, which should be characterized in a longitudinal study.

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