Characteristics of type 2 diabetes in terms of insulin resistance in Korea

Jong Suk Park, Chul Sik Kim, Joo Young Nam, Dol Mi Kim, Min Ho Jo, Jina Park, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh

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Abstract

The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. Subjects were classified in tertiles according to ISI (insulin sensitivity index), and the tertile I (the insulin-resistant group) and tertile III (the insulin-sensitive group) clinical and biochemical parameters were compared. Age, waist circumference (WC), systolic blood pressure (SBP), HbA1c, body fat content, and fasting plasma glucose were significantly higher in tertile I than tertile III (all p<0.05). The frequency of hypertension and family history of cerebrovascular disease (CVD) were greater in tertile I than III (p< 0.05). To evaluate the factors affecting ISI, multiple regression was performed, and age, WC, SBP, HbA1c, and body fat content were found to be independently related to insulin resistance (p<0.05). Old age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients.

Original languageEnglish
Pages (from-to)484-490
Number of pages7
JournalYonsei medical journal
Volume46
Issue number4
DOIs
Publication statusPublished - 2005 Aug 31

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, J. S., Kim, C. S., Nam, J. Y., Kim, D. M., Jo, M. H., Park, J., Ahn, C. W., Cha, B. S., Lim, S. K., Kim, K. R., Lee, H. C., & Huh, K. B. (2005). Characteristics of type 2 diabetes in terms of insulin resistance in Korea. Yonsei medical journal, 46(4), 484-490. https://doi.org/10.3349/ymj.2005.46.4.484