Characteristics, outcomes and predictors of long-term mortality for patients hospitalized for acute heart failure

A report from the Korean heart failure registry

Dong Ju Choi, Seongwoo Han, Eun Seok Jeon, Myeong Chan Cho, Jae Joong Kim, Byungsu Yoo, Mi Seung Shin, In Whan Seong, Youngkeun Ahn, seokmin kang, Yung Jo Kim, Hyung Seop Kim, Shung Chull Chae, Byung Hee Oh, Myung Mook Lee, Kyu Hyung Ryu

Research output: Contribution to journalArticle

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Abstract

Background and Objectives: Acute heart failure (AHF) is associated with a poor prognosis and it requires repeated hospitalizations. However, there are few studies on the characteristics, treatment and prognostic factors of AHF. The aims of this study were to describe the clinical characteristics, management and outcomes of the patients hospitalized for AHF in Korea. Subjects and Methods: We analyzed the clinical data of 3,200 hospitalization episodes that were recorded between June 2004 and April 2009 from the Korean Heart Failure (KorHF) Registry database. The mean age was 67.6114.3 years and 50% of the patients were female. Results: Twenty-nine point six percent (29.6%) of the patients had a history of previous HF and 52.3% of the patients had ischemic heart disease. Left ventricular ejection fraction (LVEF) was reported for 89% of the patients. The mean LVEF was 38.5±15.7% and 26.1% of the patients had preserved systolic function (LVEF >50%), which was more prevalent in the females (34.0% vs. 18.4%, respectively, p<0.001). At discharge, 58.6% of the patients received beta-blockers (BB), 53.7% received either angiotensin converting enzyme-inhibitors or angiotensin receptor blockers (ACEi/ARB), and 58.4% received both BB and ACEi/ARB. The 1-, 2-, 3- and 4-year mortality rates were 15%, 21%, 26% and 30%, respectively. Multivariate analysis revealed that advanced age {hazard ratio: 1.023 (95% confidence interval: 1.004-1.042); p=0.020}, a previous history of heart failure {1.735 (1.150-2.618); p=0.009}, anemia {1.973 (1.271-3.063); p=0.002}, hyponatremia {1.861 (1.184-2.926); p= 0.007}, a high level of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) {3.152 (1.450-6.849); p=0.004} and the use of BB at discharge {0.599 (0.360-0.997); p=0.490} were significantly associated with total death. Conclusion: We present here the characteristics and prognosis of an unselected population of AHF patients in Korea. The long-term mortality rate was comparable to that reported in other countries. The independent clinical risk factors included age, a previous history of heart failure, anemia, hyponatremia, a high NT-proBNP level and taking BB at discharge.

Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalKorean Circulation Journal
Volume41
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

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Registries
Heart Failure
Mortality
Stroke Volume
Hyponatremia
Brain Natriuretic Peptide
Angiotensin Receptor Antagonists
Korea
Angiotensin-Converting Enzyme Inhibitors
Anemia
Hospitalization
Myocardial Ischemia
Multivariate Analysis
Databases
Confidence Intervals
Serum
Population

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Choi, Dong Ju ; Han, Seongwoo ; Jeon, Eun Seok ; Cho, Myeong Chan ; Kim, Jae Joong ; Yoo, Byungsu ; Shin, Mi Seung ; Seong, In Whan ; Ahn, Youngkeun ; kang, seokmin ; Kim, Yung Jo ; Kim, Hyung Seop ; Chae, Shung Chull ; Oh, Byung Hee ; Lee, Myung Mook ; Ryu, Kyu Hyung. / Characteristics, outcomes and predictors of long-term mortality for patients hospitalized for acute heart failure : A report from the Korean heart failure registry. In: Korean Circulation Journal. 2011 ; Vol. 41, No. 7. pp. 363-371.
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title = "Characteristics, outcomes and predictors of long-term mortality for patients hospitalized for acute heart failure: A report from the Korean heart failure registry",
abstract = "Background and Objectives: Acute heart failure (AHF) is associated with a poor prognosis and it requires repeated hospitalizations. However, there are few studies on the characteristics, treatment and prognostic factors of AHF. The aims of this study were to describe the clinical characteristics, management and outcomes of the patients hospitalized for AHF in Korea. Subjects and Methods: We analyzed the clinical data of 3,200 hospitalization episodes that were recorded between June 2004 and April 2009 from the Korean Heart Failure (KorHF) Registry database. The mean age was 67.6114.3 years and 50{\%} of the patients were female. Results: Twenty-nine point six percent (29.6{\%}) of the patients had a history of previous HF and 52.3{\%} of the patients had ischemic heart disease. Left ventricular ejection fraction (LVEF) was reported for 89{\%} of the patients. The mean LVEF was 38.5±15.7{\%} and 26.1{\%} of the patients had preserved systolic function (LVEF >50{\%}), which was more prevalent in the females (34.0{\%} vs. 18.4{\%}, respectively, p<0.001). At discharge, 58.6{\%} of the patients received beta-blockers (BB), 53.7{\%} received either angiotensin converting enzyme-inhibitors or angiotensin receptor blockers (ACEi/ARB), and 58.4{\%} received both BB and ACEi/ARB. The 1-, 2-, 3- and 4-year mortality rates were 15{\%}, 21{\%}, 26{\%} and 30{\%}, respectively. Multivariate analysis revealed that advanced age {hazard ratio: 1.023 (95{\%} confidence interval: 1.004-1.042); p=0.020}, a previous history of heart failure {1.735 (1.150-2.618); p=0.009}, anemia {1.973 (1.271-3.063); p=0.002}, hyponatremia {1.861 (1.184-2.926); p= 0.007}, a high level of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) {3.152 (1.450-6.849); p=0.004} and the use of BB at discharge {0.599 (0.360-0.997); p=0.490} were significantly associated with total death. Conclusion: We present here the characteristics and prognosis of an unselected population of AHF patients in Korea. The long-term mortality rate was comparable to that reported in other countries. The independent clinical risk factors included age, a previous history of heart failure, anemia, hyponatremia, a high NT-proBNP level and taking BB at discharge.",
author = "Choi, {Dong Ju} and Seongwoo Han and Jeon, {Eun Seok} and Cho, {Myeong Chan} and Kim, {Jae Joong} and Byungsu Yoo and Shin, {Mi Seung} and Seong, {In Whan} and Youngkeun Ahn and seokmin kang and Kim, {Yung Jo} and Kim, {Hyung Seop} and Chae, {Shung Chull} and Oh, {Byung Hee} and Lee, {Myung Mook} and Ryu, {Kyu Hyung}",
year = "2011",
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doi = "10.4070/kcj.2011.41.7.363",
language = "English",
volume = "41",
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journal = "Korean Circulation Journal",
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Choi, DJ, Han, S, Jeon, ES, Cho, MC, Kim, JJ, Yoo, B, Shin, MS, Seong, IW, Ahn, Y, kang, S, Kim, YJ, Kim, HS, Chae, SC, Oh, BH, Lee, MM & Ryu, KH 2011, 'Characteristics, outcomes and predictors of long-term mortality for patients hospitalized for acute heart failure: A report from the Korean heart failure registry', Korean Circulation Journal, vol. 41, no. 7, pp. 363-371. https://doi.org/10.4070/kcj.2011.41.7.363

Characteristics, outcomes and predictors of long-term mortality for patients hospitalized for acute heart failure : A report from the Korean heart failure registry. / Choi, Dong Ju; Han, Seongwoo; Jeon, Eun Seok; Cho, Myeong Chan; Kim, Jae Joong; Yoo, Byungsu; Shin, Mi Seung; Seong, In Whan; Ahn, Youngkeun; kang, seokmin; Kim, Yung Jo; Kim, Hyung Seop; Chae, Shung Chull; Oh, Byung Hee; Lee, Myung Mook; Ryu, Kyu Hyung.

In: Korean Circulation Journal, Vol. 41, No. 7, 01.07.2011, p. 363-371.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characteristics, outcomes and predictors of long-term mortality for patients hospitalized for acute heart failure

T2 - A report from the Korean heart failure registry

AU - Choi, Dong Ju

AU - Han, Seongwoo

AU - Jeon, Eun Seok

AU - Cho, Myeong Chan

AU - Kim, Jae Joong

AU - Yoo, Byungsu

AU - Shin, Mi Seung

AU - Seong, In Whan

AU - Ahn, Youngkeun

AU - kang, seokmin

AU - Kim, Yung Jo

AU - Kim, Hyung Seop

AU - Chae, Shung Chull

AU - Oh, Byung Hee

AU - Lee, Myung Mook

AU - Ryu, Kyu Hyung

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Background and Objectives: Acute heart failure (AHF) is associated with a poor prognosis and it requires repeated hospitalizations. However, there are few studies on the characteristics, treatment and prognostic factors of AHF. The aims of this study were to describe the clinical characteristics, management and outcomes of the patients hospitalized for AHF in Korea. Subjects and Methods: We analyzed the clinical data of 3,200 hospitalization episodes that were recorded between June 2004 and April 2009 from the Korean Heart Failure (KorHF) Registry database. The mean age was 67.6114.3 years and 50% of the patients were female. Results: Twenty-nine point six percent (29.6%) of the patients had a history of previous HF and 52.3% of the patients had ischemic heart disease. Left ventricular ejection fraction (LVEF) was reported for 89% of the patients. The mean LVEF was 38.5±15.7% and 26.1% of the patients had preserved systolic function (LVEF >50%), which was more prevalent in the females (34.0% vs. 18.4%, respectively, p<0.001). At discharge, 58.6% of the patients received beta-blockers (BB), 53.7% received either angiotensin converting enzyme-inhibitors or angiotensin receptor blockers (ACEi/ARB), and 58.4% received both BB and ACEi/ARB. The 1-, 2-, 3- and 4-year mortality rates were 15%, 21%, 26% and 30%, respectively. Multivariate analysis revealed that advanced age {hazard ratio: 1.023 (95% confidence interval: 1.004-1.042); p=0.020}, a previous history of heart failure {1.735 (1.150-2.618); p=0.009}, anemia {1.973 (1.271-3.063); p=0.002}, hyponatremia {1.861 (1.184-2.926); p= 0.007}, a high level of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) {3.152 (1.450-6.849); p=0.004} and the use of BB at discharge {0.599 (0.360-0.997); p=0.490} were significantly associated with total death. Conclusion: We present here the characteristics and prognosis of an unselected population of AHF patients in Korea. The long-term mortality rate was comparable to that reported in other countries. The independent clinical risk factors included age, a previous history of heart failure, anemia, hyponatremia, a high NT-proBNP level and taking BB at discharge.

AB - Background and Objectives: Acute heart failure (AHF) is associated with a poor prognosis and it requires repeated hospitalizations. However, there are few studies on the characteristics, treatment and prognostic factors of AHF. The aims of this study were to describe the clinical characteristics, management and outcomes of the patients hospitalized for AHF in Korea. Subjects and Methods: We analyzed the clinical data of 3,200 hospitalization episodes that were recorded between June 2004 and April 2009 from the Korean Heart Failure (KorHF) Registry database. The mean age was 67.6114.3 years and 50% of the patients were female. Results: Twenty-nine point six percent (29.6%) of the patients had a history of previous HF and 52.3% of the patients had ischemic heart disease. Left ventricular ejection fraction (LVEF) was reported for 89% of the patients. The mean LVEF was 38.5±15.7% and 26.1% of the patients had preserved systolic function (LVEF >50%), which was more prevalent in the females (34.0% vs. 18.4%, respectively, p<0.001). At discharge, 58.6% of the patients received beta-blockers (BB), 53.7% received either angiotensin converting enzyme-inhibitors or angiotensin receptor blockers (ACEi/ARB), and 58.4% received both BB and ACEi/ARB. The 1-, 2-, 3- and 4-year mortality rates were 15%, 21%, 26% and 30%, respectively. Multivariate analysis revealed that advanced age {hazard ratio: 1.023 (95% confidence interval: 1.004-1.042); p=0.020}, a previous history of heart failure {1.735 (1.150-2.618); p=0.009}, anemia {1.973 (1.271-3.063); p=0.002}, hyponatremia {1.861 (1.184-2.926); p= 0.007}, a high level of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) {3.152 (1.450-6.849); p=0.004} and the use of BB at discharge {0.599 (0.360-0.997); p=0.490} were significantly associated with total death. Conclusion: We present here the characteristics and prognosis of an unselected population of AHF patients in Korea. The long-term mortality rate was comparable to that reported in other countries. The independent clinical risk factors included age, a previous history of heart failure, anemia, hyponatremia, a high NT-proBNP level and taking BB at discharge.

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JF - Korean Circulation Journal

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