Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis

Fauzi S. Silbaq, Sangnae Cho, Stewart T. Cole, Patrick J. Brennan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

During DNA sequence analysis of cosmid L373 from the Mycobacterium leprae genome, an open reading frame of 1.4 kb encoding a protein with some homology to the immunodominant 34-kDa protein of Mycobacterium paratuberculosis, but lacking significant serological activity, was detected. The DNA sequence predicted a signal peptide with a modified lipoprotein consensus sequence, but the protein proved to be devoid of lipid attachment.

Original languageEnglish
Pages (from-to)5576-5579
Number of pages4
JournalInfection and Immunity
Volume66
Issue number11
Publication statusPublished - 1998 Dec 1

Fingerprint

Mycobacterium avium subsp. paratuberculosis
Mycobacterium leprae
Antigens
Cosmids
Proteins
Consensus Sequence
Protein Sorting Signals
DNA Sequence Analysis
Open Reading Frames
Lipoproteins
Genome
Lipids

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

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Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis. / Silbaq, Fauzi S.; Cho, Sangnae; Cole, Stewart T.; Brennan, Patrick J.

In: Infection and Immunity, Vol. 66, No. 11, 01.12.1998, p. 5576-5579.

Research output: Contribution to journalArticle

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