Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis

Fauzi S. Silbaq; Sang Nae Cho; Stewart T. Cole; Patrick J. Brennan

doi:10.1128/iai.66.11.5576-5579.1998

Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis

Fauzi S. Silbaq, Sang Nae Cho, Stewart T. Cole, Patrick J. Brennan

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

During DNA sequence analysis of cosmid L373 from the Mycobacterium leprae genome, an open reading frame of 1.4 kb encoding a protein with some homology to the immunodominant 34-kDa protein of Mycobacterium paratuberculosis, but lacking significant serological activity, was detected. The DNA sequence predicted a signal peptide with a modified lipoprotein consensus sequence, but the protein proved to be devoid of lipid attachment.

Original language	English
Pages (from-to)	5576-5579
Number of pages	4
Journal	Infection and Immunity
Volume	66
Issue number	11
DOIs	https://doi.org/10.1128/iai.66.11.5576-5579.1998
Publication status	Published - 1998

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/iai.66.11.5576-5579.1998

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title = "Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis",

abstract = "During DNA sequence analysis of cosmid L373 from the Mycobacterium leprae genome, an open reading frame of 1.4 kb encoding a protein with some homology to the immunodominant 34-kDa protein of Mycobacterium paratuberculosis, but lacking significant serological activity, was detected. The DNA sequence predicted a signal peptide with a modified lipoprotein consensus sequence, but the protein proved to be devoid of lipid attachment.",

author = "Silbaq, {Fauzi S.} and Cho, {Sang Nae} and Cole, {Stewart T.} and Brennan, {Patrick J.}",

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Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis. / Silbaq, Fauzi S.; Cho, Sang Nae; Cole, Stewart T.; Brennan, Patrick J.

In: Infection and Immunity, Vol. 66, No. 11, 1998, p. 5576-5579.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis

AU - Silbaq, Fauzi S.

AU - Cho, Sang Nae

AU - Cole, Stewart T.

AU - Brennan, Patrick J.

PY - 1998

Y1 - 1998

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AB - During DNA sequence analysis of cosmid L373 from the Mycobacterium leprae genome, an open reading frame of 1.4 kb encoding a protein with some homology to the immunodominant 34-kDa protein of Mycobacterium paratuberculosis, but lacking significant serological activity, was detected. The DNA sequence predicted a signal peptide with a modified lipoprotein consensus sequence, but the protein proved to be devoid of lipid attachment.

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Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis

Abstract

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UN SDGs

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