Characterization of blood using terahertz waves

Kiyoung Jeong; Yong Min Huh; Sang Hoon Kim; Yeonji Park; Joo Hiuk Son; Seung Jae Oh; Jin Suck Suh

doi:10.1117/1.JBO.18.10.107008

Characterization of blood using terahertz waves

Kiyoung Jeong, Yong Min Huh, Sang Hoon Kim, Yeonji Park, Joo Hiuk Son, Seung Jae Oh, Jin Suck Suh

Department of Radiology

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

We show that terahertz (THz) time-domain spectroscopy (TDS) can be used to characterize the blood. The complex optical constants of blood and its constituents, such as water, plasma, and red blood cells (RBCs), were obtained in the THz frequency region. The volume percentage of RBCs in blood was extracted and compared with the conventional RBC counter results. The THz absorption constants are shown to vary linearly with the RBC concentration in both normal saline and whole blood. The excellent linearity between the THz signal and the RBC concentration was also confirmed in a polyurethane resin tube using a THz imaging method. These results demonstrate that THz-TDS imaging can facilitate the quantitative analysis of blood.

Original language	English
Article number	107008
Journal	Journal of Biomedical Optics
Volume	18
Issue number	10
DOIs	https://doi.org/10.1117/1.JBO.18.10.107008
Publication status	Published - 2013 Oct

Bibliographical note

Funding Information:
This study was supported by a grant from the Korean Health Technology Research and Development Project of the Ministry for Health, Welfare and Family Affairs, Republic of Korea (HI10C19110300) and National Research Foundation of Korea (NRF) grants funded by the Ministry of Education Science and Technology, Republic of Korea (2012R1A1A2008643, and 2012R1A2A2A01047402).

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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title = "Characterization of blood using terahertz waves",

abstract = "We show that terahertz (THz) time-domain spectroscopy (TDS) can be used to characterize the blood. The complex optical constants of blood and its constituents, such as water, plasma, and red blood cells (RBCs), were obtained in the THz frequency region. The volume percentage of RBCs in blood was extracted and compared with the conventional RBC counter results. The THz absorption constants are shown to vary linearly with the RBC concentration in both normal saline and whole blood. The excellent linearity between the THz signal and the RBC concentration was also confirmed in a polyurethane resin tube using a THz imaging method. These results demonstrate that THz-TDS imaging can facilitate the quantitative analysis of blood.",

author = "Kiyoung Jeong and Huh, {Yong Min} and Kim, {Sang Hoon} and Yeonji Park and Son, {Joo Hiuk} and Oh, {Seung Jae} and Suh, {Jin Suck}",

note = "Funding Information: This study was supported by a grant from the Korean Health Technology Research and Development Project of the Ministry for Health, Welfare and Family Affairs, Republic of Korea (HI10C19110300) and National Research Foundation of Korea (NRF) grants funded by the Ministry of Education Science and Technology, Republic of Korea (2012R1A1A2008643, and 2012R1A2A2A01047402).",

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AU - Jeong, Kiyoung

AU - Huh, Yong Min

AU - Kim, Sang Hoon

AU - Park, Yeonji

AU - Son, Joo Hiuk

AU - Oh, Seung Jae

AU - Suh, Jin Suck

N1 - Funding Information: This study was supported by a grant from the Korean Health Technology Research and Development Project of the Ministry for Health, Welfare and Family Affairs, Republic of Korea (HI10C19110300) and National Research Foundation of Korea (NRF) grants funded by the Ministry of Education Science and Technology, Republic of Korea (2012R1A1A2008643, and 2012R1A2A2A01047402).

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Y1 - 2013/10

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AB - We show that terahertz (THz) time-domain spectroscopy (TDS) can be used to characterize the blood. The complex optical constants of blood and its constituents, such as water, plasma, and red blood cells (RBCs), were obtained in the THz frequency region. The volume percentage of RBCs in blood was extracted and compared with the conventional RBC counter results. The THz absorption constants are shown to vary linearly with the RBC concentration in both normal saline and whole blood. The excellent linearity between the THz signal and the RBC concentration was also confirmed in a polyurethane resin tube using a THz imaging method. These results demonstrate that THz-TDS imaging can facilitate the quantitative analysis of blood.

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Characterization of blood using terahertz waves

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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