Characterization of blood using terahertz waves

Kiyoung Jeong, yongmin Huh, Sang Hoon Kim, Yeonji Park, Joo Hiuk Son, Seung Jae Oh, Jinsuck Suh

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We show that terahertz (THz) time-domain spectroscopy (TDS) can be used to characterize the blood. The complex optical constants of blood and its constituents, such as water, plasma, and red blood cells (RBCs), were obtained in the THz frequency region. The volume percentage of RBCs in blood was extracted and compared with the conventional RBC counter results. The THz absorption constants are shown to vary linearly with the RBC concentration in both normal saline and whole blood. The excellent linearity between the THz signal and the RBC concentration was also confirmed in a polyurethane resin tube using a THz imaging method. These results demonstrate that THz-TDS imaging can facilitate the quantitative analysis of blood.

Original languageEnglish
Article number107008
JournalJournal of Biomedical Optics
Volume18
Issue number10
DOIs
Publication statusPublished - 2013 Oct 1

Fingerprint

Terahertz waves
erythrocytes
blood
Blood
polyurethane resins
spectroscopy
quantitative analysis
linearity
counters
Spectroscopy
tubes
Imaging techniques
Optical constants
water
Polyurethanes
Cells

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Jeong, Kiyoung ; Huh, yongmin ; Kim, Sang Hoon ; Park, Yeonji ; Son, Joo Hiuk ; Oh, Seung Jae ; Suh, Jinsuck. / Characterization of blood using terahertz waves. In: Journal of Biomedical Optics. 2013 ; Vol. 18, No. 10.
@article{7ee47cd78851471593e74b00cf7385b1,
title = "Characterization of blood using terahertz waves",
abstract = "We show that terahertz (THz) time-domain spectroscopy (TDS) can be used to characterize the blood. The complex optical constants of blood and its constituents, such as water, plasma, and red blood cells (RBCs), were obtained in the THz frequency region. The volume percentage of RBCs in blood was extracted and compared with the conventional RBC counter results. The THz absorption constants are shown to vary linearly with the RBC concentration in both normal saline and whole blood. The excellent linearity between the THz signal and the RBC concentration was also confirmed in a polyurethane resin tube using a THz imaging method. These results demonstrate that THz-TDS imaging can facilitate the quantitative analysis of blood.",
author = "Kiyoung Jeong and yongmin Huh and Kim, {Sang Hoon} and Yeonji Park and Son, {Joo Hiuk} and Oh, {Seung Jae} and Jinsuck Suh",
year = "2013",
month = "10",
day = "1",
doi = "10.1117/1.JBO.18.10.107008",
language = "English",
volume = "18",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "10",

}

Characterization of blood using terahertz waves. / Jeong, Kiyoung; Huh, yongmin; Kim, Sang Hoon; Park, Yeonji; Son, Joo Hiuk; Oh, Seung Jae; Suh, Jinsuck.

In: Journal of Biomedical Optics, Vol. 18, No. 10, 107008, 01.10.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characterization of blood using terahertz waves

AU - Jeong, Kiyoung

AU - Huh, yongmin

AU - Kim, Sang Hoon

AU - Park, Yeonji

AU - Son, Joo Hiuk

AU - Oh, Seung Jae

AU - Suh, Jinsuck

PY - 2013/10/1

Y1 - 2013/10/1

N2 - We show that terahertz (THz) time-domain spectroscopy (TDS) can be used to characterize the blood. The complex optical constants of blood and its constituents, such as water, plasma, and red blood cells (RBCs), were obtained in the THz frequency region. The volume percentage of RBCs in blood was extracted and compared with the conventional RBC counter results. The THz absorption constants are shown to vary linearly with the RBC concentration in both normal saline and whole blood. The excellent linearity between the THz signal and the RBC concentration was also confirmed in a polyurethane resin tube using a THz imaging method. These results demonstrate that THz-TDS imaging can facilitate the quantitative analysis of blood.

AB - We show that terahertz (THz) time-domain spectroscopy (TDS) can be used to characterize the blood. The complex optical constants of blood and its constituents, such as water, plasma, and red blood cells (RBCs), were obtained in the THz frequency region. The volume percentage of RBCs in blood was extracted and compared with the conventional RBC counter results. The THz absorption constants are shown to vary linearly with the RBC concentration in both normal saline and whole blood. The excellent linearity between the THz signal and the RBC concentration was also confirmed in a polyurethane resin tube using a THz imaging method. These results demonstrate that THz-TDS imaging can facilitate the quantitative analysis of blood.

UR - http://www.scopus.com/inward/record.url?scp=84892649592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892649592&partnerID=8YFLogxK

U2 - 10.1117/1.JBO.18.10.107008

DO - 10.1117/1.JBO.18.10.107008

M3 - Article

VL - 18

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 10

M1 - 107008

ER -