We show that terahertz (THz) time-domain spectroscopy (TDS) can be used to characterize the blood. The complex optical constants of blood and its constituents, such as water, plasma, and red blood cells (RBCs), were obtained in the THz frequency region. The volume percentage of RBCs in blood was extracted and compared with the conventional RBC counter results. The THz absorption constants are shown to vary linearly with the RBC concentration in both normal saline and whole blood. The excellent linearity between the THz signal and the RBC concentration was also confirmed in a polyurethane resin tube using a THz imaging method. These results demonstrate that THz-TDS imaging can facilitate the quantitative analysis of blood.
Bibliographical noteFunding Information:
This study was supported by a grant from the Korean Health Technology Research and Development Project of the Ministry for Health, Welfare and Family Affairs, Republic of Korea (HI10C19110300) and National Research Foundation of Korea (NRF) grants funded by the Ministry of Education Science and Technology, Republic of Korea (2012R1A1A2008643, and 2012R1A2A2A01047402).
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering