Characterization of CD8+ CD57+ T cells in patients with acute myocardial infarction

Hee Tae Yu, Jong Chan Youn, Jino Lee, Seunghyun Park, Ho Seok Chi, Jungsul Lee, Chulhee Choi, Sungha Park, Donghoon Choi, Jong Won Ha, Eui Cheol Shin

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20 Citations (Scopus)

Abstract

Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction (MI). We studied the immunological characteristics and clinical impact of CD8+ CD57+ T cells in acute MI patients. The frequency of CD57+ cells among CD8+ T cells was examined in peripheral blood sampled the morning after acute MI events. Interestingly, the frequency of CD57+ cells in the CD8+ T-cell population correlated with cardiovascular mortality 6 months after acute MI. The immunological characteristics of CD8+ CD57+ T cells were elucidated by surface immunophenotyping, intracellular cytokine staining and flow cytometry. Immunophenotyping revealed that the CD8+ CD57+ T cells were activated, senescent T cells with pro-inflammatory and tissue homing properties. Because a high frequency of CD8+ CD57+ T cells is associated with short-term cardiovascular mortality in acute MI patients, this specific subset of CD8+ T cells might contribute to acute coronary events via their pro-inflammatory and high cytotoxic capacities. Identification of a pathogenic CD8+ T-cell subset expressing CD57 may offer opportunities for the evaluation and management of acute MI.

Original languageEnglish
Pages (from-to)466-473
Number of pages8
JournalCellular and Molecular Immunology
Volume12
Issue number4
DOIs
Publication statusPublished - 2015 Jul 7

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Tae Yu, H., Youn, J. C., Lee, J., Park, S., Chi, H. S., Lee, J., Choi, C., Park, S., Choi, D., Ha, J. W., & Shin, E. C. (2015). Characterization of CD8+ CD57+ T cells in patients with acute myocardial infarction. Cellular and Molecular Immunology, 12(4), 466-473. https://doi.org/10.1038/cmi.2014.74