Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity

Hyang Joo Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The purpose of this study was to comprehensively characterize head and neck squamous cell carcinoma (HNSCC) arising in young patients (<45 years old). Methods: We performed immunohistochemistry, silver, and fluorescence in situ hybridization using samples obtained from 396 radically resected cases among 1787 HNSCCs. Results: Young age HNSCCs occurred in 10.9% (194/1787) and were most common in the oral tongue (50.5%). They revealed distinctively lower frequency of p16 positivity, high c-MET expression, MET copy number gain, and lower pan-Trk expression. PD-L1 positivity in tumor cells and ICOS+ tumor infiltrating lymphocytes (TILs) were higher in the young age. Perineural invasion, PD-L1 positivity, and higher ratio of CD163+ tumor infiltrating macrophages to CD8 + TILs were determined to be independent factors for poor progression-free survival. Conclusion: Characterizing these features of young age HNSCC may help to identify the underlying pathogenesis and to improve patient outcome through different treatment strategies.

Original languageEnglish
Pages (from-to)198-207
Number of pages10
JournalHead and Neck
Volume41
Issue number1
DOIs
Publication statusPublished - 2019 Jan

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Tumor-Infiltrating Lymphocytes
Immunity
Fluorescence In Situ Hybridization
Silver
Tongue
Disease-Free Survival
Neoplasms
Immunohistochemistry
Macrophages
Carcinoma, squamous cell of head and neck
Therapeutics

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

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abstract = "Background: The purpose of this study was to comprehensively characterize head and neck squamous cell carcinoma (HNSCC) arising in young patients (<45 years old). Methods: We performed immunohistochemistry, silver, and fluorescence in situ hybridization using samples obtained from 396 radically resected cases among 1787 HNSCCs. Results: Young age HNSCCs occurred in 10.9{\%} (194/1787) and were most common in the oral tongue (50.5{\%}). They revealed distinctively lower frequency of p16 positivity, high c-MET expression, MET copy number gain, and lower pan-Trk expression. PD-L1 positivity in tumor cells and ICOS+ tumor infiltrating lymphocytes (TILs) were higher in the young age. Perineural invasion, PD-L1 positivity, and higher ratio of CD163+ tumor infiltrating macrophages to CD8 + TILs were determined to be independent factors for poor progression-free survival. Conclusion: Characterizing these features of young age HNSCC may help to identify the underlying pathogenesis and to improve patient outcome through different treatment strategies.",
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Characterization of head and neck squamous cell carcinoma arising in young patients : Particular focus on molecular alteration and tumor immunity. / Ryu, Hyang Joo; Kim, Eun Kyung; Cho, Byoung Chul; Yoon, Sun Och.

In: Head and Neck, Vol. 41, No. 1, 01.2019, p. 198-207.

Research output: Contribution to journalArticle

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