Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea

Sangmi Ryou, Myeongsu Yoo, Kisoon Kim, Sangsoo Kim, Sang Il Kim, Youn Jeong Kim, Dae Won Park, Jun Yong Choi, Hyo Youl Kim, Jung Ho Kim, Joon Young Song, Shin Woo Kim, Hyun Ha Chang, Bo Youl Choi, Mee Kyung Kee

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1 Citation (Scopus)


In Korea, subtype B is the predominant variant of HIV-1, but full genome sequencing and analysis of its viral variants are lacking. We performed near full-length genome (NFLG) sequencing and phylogenetic and recombination analyses of fifty plasma samples from HIV-positive men who have sex with men (MSM) from a Korea HIV/AIDS cohort study. Viral genomes were amplified and the near-full-length sequences were determined using next-generation sequencing (NGS) and Sanger sequencing. We focused on the HIV-1 subtype classification and identification of HIV recombinants. Twelve HIV-1 NFLGs were determined: ten were subtyped as pure HIV-1 subtype B and two recombinant strains as a common subtype CRF07_BC, and a novel subtype CRF43_02G recombined with CRF02_AG again, or a new CRF02_AG and subtype G recombinant. For the ten NFLGs determined by NGS, “the novel recombinant emerged at approximately 2003 and the other nine subtype B about 2004 or 2005”. This is the first report analyzing HIV-1 NFLG, including recombinants and clinical characteristics, by subtype among MSM in Korea. Our results provide novel insights for understanding the recombinants in the HIV-1 epidemic in Korea.

Original languageEnglish
Article number4122
JournalScientific reports
Issue number1
Publication statusPublished - 2021 Dec

Bibliographical note

Funding Information:
This research was supported by an intramural grant of the Korea National Institute of Health (2017-NI51003-00), Korea HIV/AIDS cohort study (2016-ER5103-02), and National Biobank of Korea (KBN-2018-045) from the Korea Centers for Disease Control and Prevention, Korea.

Publisher Copyright:
© 2021, The Author(s).

All Science Journal Classification (ASJC) codes

  • General


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