Chelation-assisted β-alkylation of α,β-unsaturated ketone using Rh(I) catalyst and dialkyl amine

Chul Ho Jun, Choong Woon Moon, Young Min Kim, Hyuk Lee, Jun Hee Lee

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A new Rh(I)-catalyzed β-alkylation of 4-phenyl-3-buten-2-one (1) was developed by utilizing diethylamine (5a) as a chelation-assistant tool. The key feature of this reaction is the vinyl C-H activation driven by amine-assisted cyclometalation to give the β,γ-unsaturated ketones 7 as a major product.

Original languageEnglish
Pages (from-to)4233-4236
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number23
DOIs
Publication statusPublished - 2002 Jun 3

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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