Chelation-assisted Rh(I)-catalyzed ketone synthesis from allylic alcohols and alkenes through C-H and C-C bond activations under microwave irradiation was developed. Aldimine is formed via olefin isomerization of allyl alcohol under Rh(I) catalysis and condensation with 2-amino-3-picoline, followed by continuous C-H and C-C bond activations to produce a dialkyl ketone. The addition of piperidine accelerates the reaction rate by promoting aldimine formation under microwave conditions.
Bibliographical noteFunding Information:
This study was financially supported by a grant from the National Research Foundation of Korea (NRF) (Grant 2016-R-1A2b4009460).Noaitnal Research Foundoaitn Koera 2(016-R-1A2b400946)
© Georg Thieme Verlag Stuttgart New York.
All Science Journal Classification (ASJC) codes
- Organic Chemistry