In this study, multilayer films with two components, block copolymer micelles (BCM) and graphene oxide were prepared. To adjust the ratio of the model drugs (coumarin-6) loaded in the BCMs, we used BCM at pH values of 5.5 and 8.5. However, the release behavior of a model drugs was rapid, and most of drugs was released within 24 h. Therefore, to control the release rate of the drugs, we used two methods to modify the films: chemical modification of the inner structure and modification of the external structure. These two modifications were achieved by crosslinking and the addition of external layers, respectively, and we investigated the effects of these modifications on the release of the model drug. We observed a slow release profile, from 24 to almost 70 h, in the film modified with an external layer. In contrast, the crosslinked film showed different release profile that was dependent on the pH of the BCMs in the film. When the pH of the BCMs in the film was 5.5, the release of the drug was rapid, more so than the unmodified film. When the pH of the BCM in the film was 8.5, the drug release was similar to that of the unmodified film.
Bibliographical noteFunding Information:
This research was supported by the Chung-Ang University Graduate Research Scholarship in 2017. This research was also supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIP; Grants 2012M3A9C6050104 ). This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health &Welfare, Republic of Korea ( HI14C-3266 ).
© 2017 The Korean Society of Industrial and Engineering Chemistry
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)