Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells

Nguyen Xuan Nhiem, Nguyen Trung Tuong, Pham Thanh Ky, Lalita Subedi, Seon Ju Park, Tran Minh Ngoc, Pham Hai Yen, Bui Huu Tai, Tran Hong Quang, Phan Van Kiem, Sun Yeou Kim, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)-9,9′-epoxy-3,5,3′,5′-tetramethoxylignan-4,4′,7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3 μm.

Original languageEnglish
Article numbere1700013
JournalChemistry and Biodiversity
Volume14
Issue number8
DOIs
Publication statusPublished - 2017 Aug

Bibliographical note

Funding Information:
This research is funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.79 and was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2016R1A2B4006742).

Publisher Copyright:
© 2017 Wiley-VHCA AG, Zurich, Switzerland

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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