Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells

Nguyen Xuan Nhiem, Nguyen Trung Tuong, Pham Thanh Ky, Lalita Subedi, Seon Ju Park, Tran Minh Ngoc, Pham Hai Yen, Bui Huu Tai, Tran Hong Quang, Phan Van Kiem, Sun Yeou Kim, Seung Hyun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)-9,9′-epoxy-3,5,3′,5′-tetramethoxylignan-4,4′,7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3 μm.

Original languageEnglish
Article numbere1700013
JournalChemistry and Biodiversity
Volume14
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

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Inhibitory Concentration 50
Traditional Medicine
Medicinal Plants
Nitric Oxide
Nitric oxide
Medicine
Therapeutics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

Cite this

Nhiem, Nguyen Xuan ; Tuong, Nguyen Trung ; Ky, Pham Thanh ; Subedi, Lalita ; Park, Seon Ju ; Ngoc, Tran Minh ; Yen, Pham Hai ; Tai, Bui Huu ; Quang, Tran Hong ; Kiem, Phan Van ; Kim, Sun Yeou ; Kim, Seung Hyun. / Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells. In: Chemistry and Biodiversity. 2017 ; Vol. 14, No. 8.
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Nhiem, NX, Tuong, NT, Ky, PT, Subedi, L, Park, SJ, Ngoc, TM, Yen, PH, Tai, BH, Quang, TH, Kiem, PV, Kim, SY & Kim, SH 2017, 'Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells', Chemistry and Biodiversity, vol. 14, no. 8, e1700013. https://doi.org/10.1002/cbdv.201700013

Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells. / Nhiem, Nguyen Xuan; Tuong, Nguyen Trung; Ky, Pham Thanh; Subedi, Lalita; Park, Seon Ju; Ngoc, Tran Minh; Yen, Pham Hai; Tai, Bui Huu; Quang, Tran Hong; Kiem, Phan Van; Kim, Sun Yeou; Kim, Seung Hyun.

In: Chemistry and Biodiversity, Vol. 14, No. 8, e1700013, 01.08.2017.

Research output: Contribution to journalArticle

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T1 - Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells

AU - Nhiem, Nguyen Xuan

AU - Tuong, Nguyen Trung

AU - Ky, Pham Thanh

AU - Subedi, Lalita

AU - Park, Seon Ju

AU - Ngoc, Tran Minh

AU - Yen, Pham Hai

AU - Tai, Bui Huu

AU - Quang, Tran Hong

AU - Kiem, Phan Van

AU - Kim, Sun Yeou

AU - Kim, Seung Hyun

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)-9,9′-epoxy-3,5,3′,5′-tetramethoxylignan-4,4′,7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3 μm.

AB - Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)-9,9′-epoxy-3,5,3′,5′-tetramethoxylignan-4,4′,7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3 μm.

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