Chemical components from the leaves of Ardisia insularis and their cytotoxic activity

Nguyen Thi Hong Van, Trinh Anh Vien, Phan Van Kiem, Chau Van Minh, Nguyen Xuan Nhiem, Pham Quoc Long, Luu Tuan Anh, Nanyoung Kim, Seonju Park, Seung Hyun Kim

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2 Citations (Scopus)

Abstract

One new oleanane triterpene glycoside, ardinsuloside (1), and twelve known compounds, demethoxybergenin (2), norbergenin (3), bergenin (4), 4-O-galloylbergenin (5), quercitrin (6), myricitrin (7), myricetin 3-O-(3′′-O-galloyl)-α-l-rhamnopyranoside (8), desmanthine-2 (9), epicatechin 3-O-galloyl ester (10), 3′-methoxyepicatechin 3-O-galloyl ester (11), gallic acid (12), and methyl galloate (13) were isolated from the leaves of Ardisia insularis. Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on three cancer cell lines namely A-549 (human lung cancer), HT-29 (Human colon adenocarcinoma), and OVCAR (human ovarian carcinoma). The results revealed that compound 1 inhibited A-549, HT-29, and OVCAR cell lines with IC 50 values of 8.5 ± 1.2, 16.4 ± 3.1, and 13.6 ± 2.4 μM, respectively. The remaining compound showed weak cytotoxic activity. This result indicated that compound 1 could be useful in the treatment of cancer disease.

Original languageEnglish
Pages (from-to)1926-1931
Number of pages6
JournalArchives of pharmacal research
Volume38
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Van, N. T. H., Vien, T. A., Van Kiem, P., Van Minh, C., Nhiem, N. X., Long, P. Q., Anh, L. T., Kim, N., Park, S., & Kim, S. H. (2015). Chemical components from the leaves of Ardisia insularis and their cytotoxic activity. Archives of pharmacal research, 38(11), 1926-1931. https://doi.org/10.1007/s12272-015-0591-x