Three new compounds, (3S)-dihydrobonducellin 8-O-β-d-glucopyranoside (1), 3′,5′-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined by extensive spectroscopic methods, including 1D and 2D NMR. All the isolated compounds were evaluated for their antiviral activity in HRV1B-, CVB3-, and EV71-infected cells. Among the tested compounds, three flavonoids (4–6) and two stilbenes (12 and 14) exhibited significant antiviral activity. This is the first phytochemical investigation of C. latisiliqua twigs.
Bibliographical noteFunding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] and the Basic Research Infrastructure Support Program [University-Centered Labs-2018R1A6A1A03023718] funded by the Ministry of Education, Science and Technology, Republic of Korea.
© 2019, The Japanese Society of Pharmacognosy.
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry