Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses

Nguyen Thi Hong Van, Trinh Anh Vien, Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Pham Quoc Long, Luu Tuan Anh, Nguyen Manh Cuong, Jae Hyoung Song, Hyun Jeong Ko, Nanyoung Kim, Seon Ju Parka, Seung Hyun Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Using a combination of chromatographic methods, one new flavonol glycoside, myricetin 3,7-di-O-α-L-rhamnopyranoside (1), and nine known compounds myricitrin (2), quercetin 3,7-di-O-α-L-rhamnopyranoside (3), quercitrin (4), desmanthin-1 (5), myricetin 3-O-(3″-O-galloyl)-α-L- rhamnopyranoside (6), (+)-catechin (7), benzyl O-β-D-glucopyranoside (8), 2-phenylethyl O-β-D-glucopyranoside (9), and corilagin (10) were isolated from the leaves of Ardisia splendens Pit. Based on an in vitro test against Coxsackie viruses A16 by SRB assay, only compounds 2, 5, and 10 exhibited activity against Coxsackie viruses A16 with IC50 values of 40.1, 32.2, and 30.5 μM, respectively. This result suggested that compounds 2, 5, and 10 might be potential agents for treating hand, foot and mouth diseases.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalNatural product communications
Volume9
Issue number5
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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  • Cite this

    Van, N. T. H., Vien, T. A., Nhiem, N. X., Van Kiem, P., Van Minh, C., Long, P. Q., Anh, L. T., Cuong, N. M., Song, J. H., Ko, H. J., Kim, N., Parka, S. J., & Kim, S. H. (2014). Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses. Natural product communications, 9(5), 643-645.