Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses

Nguyen Thi Hong Van, Trinh Anh Vien, Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Pham Quoc Long, Luu Tuan Anh, Nguyen Manh Cuong, Jae Hyoung Song, Hyun Jeong Ko, Nanyoung Kim, Seon Ju Parka, Seung Hyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Using a combination of chromatographic methods, one new flavonol glycoside, myricetin 3,7-di-O-α-L-rhamnopyranoside (1), and nine known compounds myricitrin (2), quercetin 3,7-di-O-α-L-rhamnopyranoside (3), quercitrin (4), desmanthin-1 (5), myricetin 3-O-(3″-O-galloyl)-α-L- rhamnopyranoside (6), (+)-catechin (7), benzyl O-β-D-glucopyranoside (8), 2-phenylethyl O-β-D-glucopyranoside (9), and corilagin (10) were isolated from the leaves of Ardisia splendens Pit. Based on an in vitro test against Coxsackie viruses A16 by SRB assay, only compounds 2, 5, and 10 exhibited activity against Coxsackie viruses A16 with IC50 values of 40.1, 32.2, and 30.5 μM, respectively. This result suggested that compounds 2, 5, and 10 might be potential agents for treating hand, foot and mouth diseases.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalNatural Product Communications
Volume9
Issue number5
Publication statusPublished - 2014 Jan 1

Fingerprint

Ardisia
Enterovirus
myricetin
hand, foot and mouth disease
Hand, Foot and Mouth Disease
quercitrin
viruses
Catechin
Quercetin
Glycosides
catechin
flavonols
quercetin
Inhibitory Concentration 50
inhibitory concentration 50
glycosides
leaves
assays
testing
methodology

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Cite this

Van, N. T. H., Vien, T. A., Nhiem, N. X., Van Kiem, P., Van Minh, C., Long, P. Q., ... Kim, S. H. (2014). Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses. Natural Product Communications, 9(5), 643-645.
Van, Nguyen Thi Hong ; Vien, Trinh Anh ; Nhiem, Nguyen Xuan ; Van Kiem, Phan ; Van Minh, Chau ; Long, Pham Quoc ; Anh, Luu Tuan ; Cuong, Nguyen Manh ; Song, Jae Hyoung ; Ko, Hyun Jeong ; Kim, Nanyoung ; Parka, Seon Ju ; Kim, Seung Hyun. / Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses. In: Natural Product Communications. 2014 ; Vol. 9, No. 5. pp. 643-645.
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Van, NTH, Vien, TA, Nhiem, NX, Van Kiem, P, Van Minh, C, Long, PQ, Anh, LT, Cuong, NM, Song, JH, Ko, HJ, Kim, N, Parka, SJ & Kim, SH 2014, 'Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses', Natural Product Communications, vol. 9, no. 5, pp. 643-645.

Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses. / Van, Nguyen Thi Hong; Vien, Trinh Anh; Nhiem, Nguyen Xuan; Van Kiem, Phan; Van Minh, Chau; Long, Pham Quoc; Anh, Luu Tuan; Cuong, Nguyen Manh; Song, Jae Hyoung; Ko, Hyun Jeong; Kim, Nanyoung; Parka, Seon Ju; Kim, Seung Hyun.

In: Natural Product Communications, Vol. 9, No. 5, 01.01.2014, p. 643-645.

Research output: Contribution to journalArticle

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AU - Van, Nguyen Thi Hong

AU - Vien, Trinh Anh

AU - Nhiem, Nguyen Xuan

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AU - Van Minh, Chau

AU - Long, Pham Quoc

AU - Anh, Luu Tuan

AU - Cuong, Nguyen Manh

AU - Song, Jae Hyoung

AU - Ko, Hyun Jeong

AU - Kim, Nanyoung

AU - Parka, Seon Ju

AU - Kim, Seung Hyun

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Van NTH, Vien TA, Nhiem NX, Van Kiem P, Van Minh C, Long PQ et al. Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses. Natural Product Communications. 2014 Jan 1;9(5):643-645.