Chemical constituents from Schisandra perulata and their cytotoxic activity

Tran Tuan Anh, Vu Van Doan, Vu Thi Xuan, Bui Quang Tuan, Bui Huu Tai, Phan Van Kiem, Nguyen Xuan Nhiem, Nguyen The Cuong, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim, Nguyen Thi Mai

Research output: Contribution to journalArticlepeer-review

Abstract

Two new compounds, schisandrulata A (1) and schisandrulata B (5), and nine known compounds, 6-O-benzoylgomisin O (2), kadsutherin (3), γ-schizandrin (4), pinotatol (6), schisphentetralone A (7), (–)-8′-epi-aristotetralone (8), (–)-8,8′-epi-aristotetralone (9), rel-(8R,8′R)-dimethyl-(7S,7′R)-bis(3,4-methylenedioxyphenyl)tetrahydrofuran (10) and (-)-machilusin (11) were isolated from the leaves of Schisandra perulata Gagnep. Their chemical structures were determined by means of HR-ESI-MS, NMR, and CD spectra. All the compounds were evaluated for their cytotoxic activity against the human oral cancer (CAL27) and human breast cancer (MDA-MB231) cell lines. Compounds 1, 4, 7, and 9 showed potent cytotoxic activity against CAL27 cell line with IC50 values of 1.8 ± 0.2, 1.2 ± 0.1, 1.2 ± 0.2, and 2.0 ± 0.1 μM, respectively, indicating that they have stronger cytotoxic activity than that of the positive control capecitabine (IC50 value of 8.20 ± 0.75 μM). Similarly, compounds 1, 4, 7, and 9 also exhibited potent activity against the MDA-MB231 cell line with IC50 values of 3.5 ± 0.1, 1.80 ± 0.2, 0.9 ± 0.2, and 3.4 ± 0.3 μM, respectively. These results indicated that compounds 1, 4, 7, and 9 could be potential anticancer reagents for further drug discovery research.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalPhytochemistry Letters
Volume41
DOIs
Publication statusPublished - 2021 Feb

Bibliographical note

Funding Information:
This research was supported by Vietnam Ministry of Education and Training under grant number B2019-GHA-562-01 .

Publisher Copyright:
© 2020 Phytochemical Society of Europe

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

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