TY - JOUR
T1 - Chemical constituents from Schisandra sphenanthera and their cytotoxic activity
AU - Mai, Nguyen Thi
AU - Doan, Vu Van
AU - Lan, Hoang Thi Tuyet
AU - Anh, Bui Thi Mai
AU - Hoang, Nguyen Huy
AU - Tai, Bui Huu
AU - Nhiem, Nguyen Xuan
AU - Yen, Pham Hai
AU - Park, Seon Ju
AU - Seo, Yohan
AU - Namkung, Wan
AU - Kim, Seung Hyun
AU - Kiem, Phan Van
N1 - Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1–6) and five lignans (7–11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.
AB - Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1–6) and five lignans (7–11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.
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U2 - 10.1080/14786419.2019.1700247
DO - 10.1080/14786419.2019.1700247
M3 - Article
C2 - 31829042
AN - SCOPUS:85076426086
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
ER -