Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

Nguyen Thi Mai, Vu Van Doan, Hoang Thi Tuyet Lan, Bui Thi Mai Anh, Nguyen Huy Hoang, Bui Huu Tai, Nguyen Xuan Nhiem, Pham Hai Yen, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim, Phan Van Kiem

Research output: Contribution to journalArticlepeer-review

Abstract

Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1–6) and five lignans (7–11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 2019

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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