Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

Nguyen Thi Mai; Vu Van Doan; Hoang Thi Tuyet Lan; Bui Thi Mai Anh; Nguyen Huy Hoang; Bui Huu Tai; Nguyen Xuan Nhiem; Pham Hai Yen; Seon Ju Park; Yohan Seo; Wan Namkung; Seung Hyun Kim; Phan Van Kiem

doi:10.1080/14786419.2019.1700247

Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

Nguyen Thi Mai, Vu Van Doan, Hoang Thi Tuyet Lan, Bui Thi Mai Anh, Nguyen Huy Hoang, Bui Huu Tai, Nguyen Xuan Nhiem, Pham Hai Yen, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim, Phan Van Kiem

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1–6) and five lignans (7–11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC₅₀ values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.

Original language	English
Pages (from-to)	3360-3369
Number of pages	10
Journal	Natural Product Research
Volume	35
Issue number	20
DOIs	https://doi.org/10.1080/14786419.2019.1700247
Publication status	Published - 2021

Bibliographical note

Funding Information:
This research was supported by Vietnam Ministry of Education and Training under grant number HH01, 2019.

Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14786419.2019.1700247

Cite this

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title = "Chemical constituents from Schisandra sphenanthera and their cytotoxic activity",

abstract = "Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1–6) and five lignans (7–11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.",

author = "Mai, {Nguyen Thi} and Doan, {Vu Van} and Lan, {Hoang Thi Tuyet} and Anh, {Bui Thi Mai} and Hoang, {Nguyen Huy} and Tai, {Bui Huu} and Nhiem, {Nguyen Xuan} and Yen, {Pham Hai} and Park, {Seon Ju} and Yohan Seo and Wan Namkung and Kim, {Seung Hyun} and Kiem, {Phan Van}",

note = "Funding Information: This research was supported by Vietnam Ministry of Education and Training under grant number HH01, 2019. Publisher Copyright: {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

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doi = "10.1080/14786419.2019.1700247",

language = "English",

volume = "35",

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T1 - Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

AU - Mai, Nguyen Thi

AU - Doan, Vu Van

AU - Lan, Hoang Thi Tuyet

AU - Anh, Bui Thi Mai

AU - Hoang, Nguyen Huy

AU - Tai, Bui Huu

AU - Nhiem, Nguyen Xuan

AU - Yen, Pham Hai

AU - Park, Seon Ju

AU - Seo, Yohan

AU - Namkung, Wan

AU - Kim, Seung Hyun

AU - Kiem, Phan Van

N1 - Funding Information: This research was supported by Vietnam Ministry of Education and Training under grant number HH01, 2019. Publisher Copyright: © 2019 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2021

Y1 - 2021

N2 - Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1–6) and five lignans (7–11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.

AB - Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1–6) and five lignans (7–11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.

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Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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